CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	RNASampler(seed)		PknotsRG
MCC	0.779	>	0.638
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092	>	0.618 ± 0.181
Sensitivity	0.659	>	0.653
Positive Predictive Value	0.921	>	0.624
Total TP	442	>	438
Total TN	413762	>	413540
Total FP	105	<	429
Total FP CONTRA	9	<	81
Total FP INCONS	29	<	183
Total FP COMP	67	<	165
Total FN	229	<	233
P-value	1.39551335374e-08

Comparison of performance of RNASampler(seed) and PknotsRG. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(seed) and PknotsRG).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(seed) and PknotsRG).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(seed) and PknotsRG. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(seed) and PknotsRG).

Total Scores
MCC	0.779
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092
Sensitivity	0.659
Positive Predictive Value	0.921
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.44	0.36	0.54	14	21295	18	7	5	6	25
RFA_00620	Telomerase-cil links to Rfam database...	0.52	0.44	0.63	17	21918	15	2	8	5	22
RFA_00626	rne5 links to Rfam database...	0.80	0.64	1.00	56	56560	5	0	0	5	31
RFA_00627	rne5 links to Rfam database...	0.77	0.63	0.93	55	56894	8	0	4	4	32
RFA_00628	rne5 links to Rfam database...	0.78	0.64	0.95	55	57233	12	0	3	9	31
RFA_00630	rne5 links to Rfam database...	0.77	0.66	0.90	57	56890	15	0	6	9	30
RFA_00814	R2_retro_el links to Rfam database...	0.87	0.78	0.97	32	25167	6	0	1	5	9
RFA_00815	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	24499	8	0	0	8	9
RFA_00816	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	23188	6	0	1	5	10
RFA_00817	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	21913	1	0	1	0	10
RFA_00818	R2_retro_el links to Rfam database...	0.86	0.73	1.00	30	20271	6	0	0	6	11
RFA_00819	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	27934	5	0	0	5	9

Total Scores
MCC	0.638
Average MCC ± 95% Confidence Intervals	0.618 ± 0.181
Sensitivity	0.653
Positive Predictive Value	0.624
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.66	0.67	0.65	26	21281	28	6	8	14	13
RFA_00620	Telomerase-cil links to Rfam database...	0.63	0.62	0.65	24	21908	26	4	9	13	15
RFA_00626	rne5 links to Rfam database...	0.89	0.86	0.93	75	56535	28	2	4	22	12
RFA_00627	rne5 links to Rfam database...	0.73	0.70	0.76	61	56873	35	4	15	16	26
RFA_00628	rne5 links to Rfam database...	0.78	0.74	0.81	64	57212	40	0	15	25	22
RFA_00630	rne5 links to Rfam database...	0.60	0.60	0.60	52	56866	44	8	27	9	35
RFA_00814	R2_retro_el links to Rfam database...	0.91	0.95	0.87	39	25155	23	4	2	17	2
RFA_00815	R2_retro_el links to Rfam database...	0.66	0.71	0.62	29	24484	33	5	13	15	12
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.73	0.63	30	23172	26	12	6	8	11
RFA_00817	R2_retro_el links to Rfam database...	0.10	0.12	0.08	5	21885	56	16	39	1	36
RFA_00818	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	20245	56	20	36	0	41
RFA_00819	R2_retro_el links to Rfam database...	0.79	0.80	0.79	33	27924	34	0	9	25	8

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.