CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	RNASampler(seed)		RNASLOpt
MCC	0.779	>	0.568
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092	>	0.522 ± 0.139
Sensitivity	0.659	>	0.569
Positive Predictive Value	0.921	>	0.568
Total TP	442	>	382
Total TN	413762	>	413570
Total FP	105	<	380
Total FP CONTRA	9	<	93
Total FP INCONS	29	<	197
Total FP COMP	67	<	90
Total FN	229	<	289
P-value	1.38194587311e-08

Comparison of performance of RNASampler(seed) and RNASLOpt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(seed) and RNASLOpt).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(seed) and RNASLOpt).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(seed) and RNASLOpt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(seed) and RNASLOpt).

Total Scores
MCC	0.779
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092
Sensitivity	0.659
Positive Predictive Value	0.921
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.44	0.36	0.54	14	21295	18	7	5	6	25
RFA_00620	Telomerase-cil links to Rfam database...	0.52	0.44	0.63	17	21918	15	2	8	5	22
RFA_00626	rne5 links to Rfam database...	0.80	0.64	1.00	56	56560	5	0	0	5	31
RFA_00627	rne5 links to Rfam database...	0.77	0.63	0.93	55	56894	8	0	4	4	32
RFA_00628	rne5 links to Rfam database...	0.78	0.64	0.95	55	57233	12	0	3	9	31
RFA_00630	rne5 links to Rfam database...	0.77	0.66	0.90	57	56890	15	0	6	9	30
RFA_00814	R2_retro_el links to Rfam database...	0.87	0.78	0.97	32	25167	6	0	1	5	9
RFA_00815	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	24499	8	0	0	8	9
RFA_00816	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	23188	6	0	1	5	10
RFA_00817	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	21913	1	0	1	0	10
RFA_00818	R2_retro_el links to Rfam database...	0.86	0.73	1.00	30	20271	6	0	0	6	11
RFA_00819	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	27934	5	0	0	5	9

Total Scores
MCC	0.568
Average MCC ± 95% Confidence Intervals	0.522 ± 0.139
Sensitivity	0.569
Positive Predictive Value	0.568
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.18	0.18	0.18	7	21281	39	4	29	6	32
RFA_00620	Telomerase-cil links to Rfam database...	0.66	0.64	0.68	25	21908	22	2	10	10	14
RFA_00626	rne5 links to Rfam database...	0.68	0.64	0.72	56	56538	30	6	16	8	31
RFA_00627	rne5 links to Rfam database...	0.61	0.60	0.62	52	56869	41	11	21	9	35
RFA_00628	rne5 links to Rfam database...	0.89	0.84	0.95	72	57215	15	0	4	11	14
RFA_00630	rne5 links to Rfam database...	0.69	0.67	0.72	58	56872	32	5	18	9	29
RFA_00814	R2_retro_el links to Rfam database...	0.51	0.51	0.51	21	25159	29	9	11	9	20
RFA_00815	R2_retro_el links to Rfam database...	0.41	0.41	0.41	17	24490	31	1	23	7	24
RFA_00816	R2_retro_el links to Rfam database...	0.58	0.63	0.53	26	23171	26	13	10	3	15
RFA_00817	R2_retro_el links to Rfam database...	0.24	0.27	0.22	11	21896	42	12	26	4	30
RFA_00818	R2_retro_el links to Rfam database...	0.21	0.22	0.21	9	20258	39	14	20	5	32
RFA_00819	R2_retro_el links to Rfam database...	0.60	0.68	0.53	28	27913	34	16	9	9	13

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.