CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	RNASampler(seed)		RNAshapes
MCC	0.780	>	0.548
Average MCC ± 95% Confidence Intervals	0.774 ± 0.102	>	0.541 ± 0.156
Sensitivity	0.659	>	0.567
Positive Predictive Value	0.923	>	0.530
Total TP	385	>	331
Total TN	356872	>	356665
Total FP	90	<	435
Total FP CONTRA	9	<	77
Total FP INCONS	23	<	216
Total FP COMP	58	<	142
Total FN	199	<	253
P-value	2.06323189071e-08

Comparison of performance of RNASampler(seed) and RNAshapes. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(seed) and RNAshapes).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(seed) and RNAshapes).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(seed) and RNAshapes. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(seed) and RNAshapes).

Total Scores
MCC	0.780
Average MCC ± 95% Confidence Intervals	0.774 ± 0.102
Sensitivity	0.659
Positive Predictive Value	0.923
Nr of predictions	11

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.44	0.36	0.54	14	21295	18	7	5	6	25
RFA_00620	Telomerase-cil links to Rfam database...	0.52	0.44	0.63	17	21918	15	2	8	5	22
RFA_00626	rne5 links to Rfam database...	0.80	0.64	1.00	56	56560	5	0	0	5	31
RFA_00627	rne5 links to Rfam database...	0.77	0.63	0.93	55	56894	8	0	4	4	32
RFA_00628	rne5 links to Rfam database...	0.78	0.64	0.95	55	57233	12	0	3	9	31
RFA_00814	R2_retro_el links to Rfam database...	0.87	0.78	0.97	32	25167	6	0	1	5	9
RFA_00815	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	24499	8	0	0	8	9
RFA_00816	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	23188	6	0	1	5	10
RFA_00817	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	21913	1	0	1	0	10
RFA_00818	R2_retro_el links to Rfam database...	0.86	0.73	1.00	30	20271	6	0	0	6	11
RFA_00819	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	27934	5	0	0	5	9

Total Scores
MCC	0.548
Average MCC ± 95% Confidence Intervals	0.541 ± 0.156
Sensitivity	0.567
Positive Predictive Value	0.530
Nr of predictions	11

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.67	0.67	0.67	26	21282	32	1	12	19	13
RFA_00620	Telomerase-cil links to Rfam database...	0.44	0.46	0.42	18	21902	36	7	18	11	21
RFA_00626	rne5 links to Rfam database...	0.45	0.45	0.46	39	56531	61	9	37	15	48
RFA_00627	rne5 links to Rfam database...	0.63	0.61	0.66	53	56873	42	4	23	15	34
RFA_00628	rne5 links to Rfam database...	0.82	0.80	0.84	69	57209	33	1	12	20	17
RFA_00814	R2_retro_el links to Rfam database...	0.62	0.63	0.60	26	25157	26	6	11	9	15
RFA_00815	R2_retro_el links to Rfam database...	0.67	0.71	0.63	29	24485	31	1	16	14	12
RFA_00816	R2_retro_el links to Rfam database...	0.21	0.24	0.18	10	23164	47	18	28	1	31
RFA_00817	R2_retro_el links to Rfam database...	0.10	0.12	0.08	5	21881	60	21	38	1	36
RFA_00818	R2_retro_el links to Rfam database...	0.52	0.56	0.48	23	20253	31	9	16	6	18
RFA_00819	R2_retro_el links to Rfam database...	0.84	0.80	0.87	33	27928	36	0	5	31	8

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.