CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	RNASampler(seed)		RNAsubopt
MCC	0.779	>	0.643
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092	>	0.626 ± 0.120
Sensitivity	0.659	>	0.657
Positive Predictive Value	0.921	>	0.631
Total TP	442	>	441
Total TN	413762	>	413543
Total FP	105	<	439
Total FP CONTRA	9	<	81
Total FP INCONS	29	<	177
Total FP COMP	67	<	181
Total FN	229	<	230
P-value	2.1413769576e-08

Comparison of performance of RNASampler(seed) and RNAsubopt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(seed) and RNAsubopt).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(seed) and RNAsubopt).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(seed) and RNAsubopt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(seed) and RNAsubopt).

Total Scores
MCC	0.779
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092
Sensitivity	0.659
Positive Predictive Value	0.921
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.44	0.36	0.54	14	21295	18	7	5	6	25
RFA_00620	Telomerase-cil links to Rfam database...	0.52	0.44	0.63	17	21918	15	2	8	5	22
RFA_00626	rne5 links to Rfam database...	0.80	0.64	1.00	56	56560	5	0	0	5	31
RFA_00627	rne5 links to Rfam database...	0.77	0.63	0.93	55	56894	8	0	4	4	32
RFA_00628	rne5 links to Rfam database...	0.78	0.64	0.95	55	57233	12	0	3	9	31
RFA_00630	rne5 links to Rfam database...	0.77	0.66	0.90	57	56890	15	0	6	9	30
RFA_00814	R2_retro_el links to Rfam database...	0.87	0.78	0.97	32	25167	6	0	1	5	9
RFA_00815	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	24499	8	0	0	8	9
RFA_00816	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	23188	6	0	1	5	10
RFA_00817	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	21913	1	0	1	0	10
RFA_00818	R2_retro_el links to Rfam database...	0.86	0.73	1.00	30	20271	6	0	0	6	11
RFA_00819	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	27934	5	0	0	5	9

Total Scores
MCC	0.643
Average MCC ± 95% Confidence Intervals	0.626 ± 0.120
Sensitivity	0.657
Positive Predictive Value	0.631
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.63	0.67	0.60	26	21278	33	8	9	16	13
RFA_00620	Telomerase-cil links to Rfam database...	0.46	0.46	0.46	18	21906	36	7	14	15	21
RFA_00626	rne5 links to Rfam database...	0.68	0.66	0.70	57	56535	42	6	18	18	30
RFA_00627	rne5 links to Rfam database...	0.72	0.68	0.77	59	56876	33	4	14	15	28
RFA_00628	rne5 links to Rfam database...	0.89	0.86	0.91	74	57210	32	2	5	25	12
RFA_00630	rne5 links to Rfam database...	0.58	0.60	0.57	52	56861	51	12	28	11	35
RFA_00814	R2_retro_el links to Rfam database...	0.39	0.39	0.39	16	25159	40	5	20	15	25
RFA_00815	R2_retro_el links to Rfam database...	0.65	0.71	0.59	29	24482	35	5	15	15	12
RFA_00816	R2_retro_el links to Rfam database...	0.74	0.78	0.70	32	23174	24	8	6	10	9
RFA_00817	R2_retro_el links to Rfam database...	0.35	0.41	0.30	17	21889	43	11	28	4	24
RFA_00818	R2_retro_el links to Rfam database...	0.47	0.54	0.41	22	20247	39	13	19	7	19
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	31	0	1	30	2

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.