CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	RNASampler(seed)		UNAFold
MCC	0.779	>	0.645
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092	>	0.628 ± 0.165
Sensitivity	0.659	>	0.657
Positive Predictive Value	0.921	>	0.634
Total TP	442	>	441
Total TN	413762	>	413546
Total FP	105	<	417
Total FP CONTRA	9	<	87
Total FP INCONS	29	<	168
Total FP COMP	67	<	162
Total FN	229	<	230
P-value	2.04409141234e-08

Comparison of performance of RNASampler(seed) and UNAFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(seed) and UNAFold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(seed) and UNAFold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(seed) and UNAFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(seed) and UNAFold).

Total Scores
MCC	0.779
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092
Sensitivity	0.659
Positive Predictive Value	0.921
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.44	0.36	0.54	14	21295	18	7	5	6	25
RFA_00620	Telomerase-cil links to Rfam database...	0.52	0.44	0.63	17	21918	15	2	8	5	22
RFA_00626	rne5 links to Rfam database...	0.80	0.64	1.00	56	56560	5	0	0	5	31
RFA_00627	rne5 links to Rfam database...	0.77	0.63	0.93	55	56894	8	0	4	4	32
RFA_00628	rne5 links to Rfam database...	0.78	0.64	0.95	55	57233	12	0	3	9	31
RFA_00630	rne5 links to Rfam database...	0.77	0.66	0.90	57	56890	15	0	6	9	30
RFA_00814	R2_retro_el links to Rfam database...	0.87	0.78	0.97	32	25167	6	0	1	5	9
RFA_00815	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	24499	8	0	0	8	9
RFA_00816	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	23188	6	0	1	5	10
RFA_00817	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	21913	1	0	1	0	10
RFA_00818	R2_retro_el links to Rfam database...	0.86	0.73	1.00	30	20271	6	0	0	6	11
RFA_00819	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	27934	5	0	0	5	9

Total Scores
MCC	0.645
Average MCC ± 95% Confidence Intervals	0.628 ± 0.165
Sensitivity	0.657
Positive Predictive Value	0.634
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.67	0.67	0.68	26	21283	25	7	5	13	13
RFA_00620	Telomerase-cil links to Rfam database...	0.67	0.64	0.69	25	21909	24	3	8	13	14
RFA_00626	rne5 links to Rfam database...	0.87	0.84	0.91	73	56536	32	2	5	25	14
RFA_00627	rne5 links to Rfam database...	0.70	0.67	0.74	58	56875	36	4	16	16	29
RFA_00628	rne5 links to Rfam database...	0.86	0.83	0.89	71	57211	31	1	8	22	15
RFA_00630	rne5 links to Rfam database...	0.59	0.59	0.59	51	56866	48	8	28	12	36
RFA_00814	R2_retro_el links to Rfam database...	0.77	0.78	0.76	32	25158	23	4	6	13	9
RFA_00815	R2_retro_el links to Rfam database...	0.56	0.61	0.51	25	24482	36	8	16	12	16
RFA_00816	R2_retro_el links to Rfam database...	0.60	0.66	0.55	27	23171	30	13	9	8	14
RFA_00817	R2_retro_el links to Rfam database...	0.10	0.12	0.08	5	21882	58	18	40	0	36
RFA_00818	R2_retro_el links to Rfam database...	0.19	0.22	0.17	9	20247	46	19	26	1	32
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	28	0	1	27	2

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.