CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	RNASampler(seed)		Vsfold5
MCC	0.779	>	0.290
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092	>	0.287 ± 0.038
Sensitivity	0.659	>	0.303
Positive Predictive Value	0.921	>	0.280
Total TP	442	>	203
Total TN	413762	>	413517
Total FP	105	<	618
Total FP CONTRA	9	<	142
Total FP INCONS	29	<	380
Total FP COMP	67	<	96
Total FN	229	<	468
P-value	5.11462970451e-09

Comparison of performance of RNASampler(seed) and Vsfold5. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(seed) and Vsfold5).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(seed) and Vsfold5).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(seed) and Vsfold5. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(seed) and Vsfold5).

Total Scores
MCC	0.779
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092
Sensitivity	0.659
Positive Predictive Value	0.921
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.44	0.36	0.54	14	21295	18	7	5	6	25
RFA_00620	Telomerase-cil links to Rfam database...	0.52	0.44	0.63	17	21918	15	2	8	5	22
RFA_00626	rne5 links to Rfam database...	0.80	0.64	1.00	56	56560	5	0	0	5	31
RFA_00627	rne5 links to Rfam database...	0.77	0.63	0.93	55	56894	8	0	4	4	32
RFA_00628	rne5 links to Rfam database...	0.78	0.64	0.95	55	57233	12	0	3	9	31
RFA_00630	rne5 links to Rfam database...	0.77	0.66	0.90	57	56890	15	0	6	9	30
RFA_00814	R2_retro_el links to Rfam database...	0.87	0.78	0.97	32	25167	6	0	1	5	9
RFA_00815	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	24499	8	0	0	8	9
RFA_00816	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	23188	6	0	1	5	10
RFA_00817	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	21913	1	0	1	0	10
RFA_00818	R2_retro_el links to Rfam database...	0.86	0.73	1.00	30	20271	6	0	0	6	11
RFA_00819	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	27934	5	0	0	5	9

Total Scores
MCC	0.290
Average MCC ± 95% Confidence Intervals	0.287 ± 0.038
Sensitivity	0.303
Positive Predictive Value	0.280
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.41	0.49	0.35	19	21267	43	15	20	8	20
RFA_00620	Telomerase-cil links to Rfam database...	0.23	0.23	0.24	9	21907	41	6	23	12	30
RFA_00626	rne5 links to Rfam database...	0.31	0.31	0.32	27	56531	62	15	43	4	60
RFA_00627	rne5 links to Rfam database...	0.26	0.26	0.26	23	56863	69	16	51	2	64
RFA_00628	rne5 links to Rfam database...	0.34	0.35	0.34	30	57202	66	13	46	7	56
RFA_00630	rne5 links to Rfam database...	0.27	0.29	0.26	25	56857	78	13	58	7	62
RFA_00814	R2_retro_el links to Rfam database...	0.31	0.34	0.29	14	25151	46	10	25	11	27
RFA_00815	R2_retro_el links to Rfam database...	0.22	0.24	0.20	10	24480	46	18	23	5	31
RFA_00816	R2_retro_el links to Rfam database...	0.31	0.32	0.30	13	23177	38	12	18	8	28
RFA_00817	R2_retro_el links to Rfam database...	0.32	0.34	0.30	14	21898	35	10	23	2	27
RFA_00818	R2_retro_el links to Rfam database...	0.19	0.20	0.19	8	20258	41	8	27	6	33
RFA_00819	R2_retro_el links to Rfam database...	0.27	0.27	0.28	11	27926	53	6	23	24	30

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.