CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAalifold(20) - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAalifold(20) & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric RNAalifold(20) Carnac(seed)
MCC 0.737 > 0.000
Average MCC ± 95% Confidence Intervals 0.733 ± 0.058 > 0.000 ± 0.000
Sensitivity 0.627 > 0.000
Positive Predictive Value 0.868 > 0.000
Total TP 830 > 0
Total TN 737119 < 738075
Total FP 166 > 0
Total FP CONTRA 9 > 0
Total FP INCONS 117 > 0
Total FP COMP 40 > 0
Total FN 494 < 1324
P-value 1.93248927742e-08

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Performance plots


  1. Comparison of performance of RNAalifold(20) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(20) and Carnac(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(20) and Carnac(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(20) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(20) and Carnac(seed)).

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Performance of RNAalifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(20)

Total Base Pair Counts
Total TP 830
Total TN 737119
Total FP 166
Total FP CONTRA 9
Total FP INCONS 117
Total FP COMP 40
Total FN 494
Total Scores
MCC 0.737
Average MCC ± 95% Confidence Intervals 0.733 ± 0.058
Sensitivity 0.627
Positive Predictive Value 0.868
Nr of predictions 13

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2. Individual counts for RNAalifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00599 0.75 0.65 0.87 72 101392 18 0 11 7 39
RFA_00601 0.75 0.66 0.85 75 99147 17 0 13 4 39
RFA_00602 0.65 0.54 0.78 63 101394 21 0 18 3 53
SRP_00011 0.74 0.65 0.83 68 46278 17 0 14 3 36
SRP_00015 0.78 0.72 0.86 71 46277 20 0 12 8 28
SRP_00152 0.73 0.64 0.84 66 45674 16 5 8 3 37
SRP_00178 0.76 0.60 0.97 61 45690 3 0 2 1 41
SRP_00179 0.74 0.58 0.94 61 45991 7 0 4 3 44
SRP_00181 0.66 0.50 0.88 51 45998 9 0 7 2 51
SRP_00182 0.89 0.83 0.94 84 45967 7 0 5 2 17
SRP_00184 0.82 0.74 0.90 74 45974 11 0 8 3 26
SRP_00188 0.78 0.71 0.86 56 31060 10 0 9 1 23
SRP_00308 0.48 0.32 0.74 28 36277 10 4 6 0 60

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 0
Total TN 738075
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 1324
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 13

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00599 0.00 0.00 0.00 0 101475 0 0 0 0 111
RFA_00601 0.00 0.00 0.00 0 99235 0 0 0 0 114
RFA_00602 0.00 0.00 0.00 0 101475 0 0 0 0 116
SRP_00011 0.00 0.00 0.00 0 46360 0 0 0 0 104
SRP_00015 0.00 0.00 0.00 0 46360 0 0 0 0 99
SRP_00152 0.00 0.00 0.00 0 45753 0 0 0 0 103
SRP_00178 0.00 0.00 0.00 0 45753 0 0 0 0 102
SRP_00179 0.00 0.00 0.00 0 46056 0 0 0 0 105
SRP_00181 0.00 0.00 0.00 0 46056 0 0 0 0 102
SRP_00182 0.00 0.00 0.00 0 46056 0 0 0 0 101
SRP_00184 0.00 0.00 0.00 0 46056 0 0 0 0 100
SRP_00188 0.00 0.00 0.00 0 31125 0 0 0 0 79
SRP_00308 0.00 0.00 0.00 0 36315 0 0 0 0 88

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.