CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAalifold(seed)		CMfinder(seed)
MCC	0.706	>	0.454
Average MCC ± 95% Confidence Intervals	0.693 ± 0.059	>	0.456 ± 0.042
Sensitivity	0.543	>	0.271
Positive Predictive Value	0.918	>	0.762
Total TP	2500	>	1249
Total TN	2621968	<	2623051
Total FP	360	<	419
Total FP CONTRA	19	<	30
Total FP INCONS	203	<	360
Total FP COMP	138	>	29
Total FN	2103	<	3354
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNAalifold(seed) and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(seed) and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and CMfinder(seed)).

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Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP	2500
Total TN	2621968
Total FP	360
Total FP CONTRA	19
Total FP INCONS	203
Total FP COMP	138
Total FN	2103

Total Scores
MCC	0.706
Average MCC ± 95% Confidence Intervals	0.693 ± 0.059
Sensitivity	0.543
Positive Predictive Value	0.918
Nr of predictions	51

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.46	0.23	0.90	27	103710	3	0	3	0	88
CRW_00016	Intron_gpI links to Rfam database...	0.45	0.23	0.90	27	77391	3	0	3	0	93
CRW_00610	Intron_gpI links to Rfam database...	0.54	0.31	0.96	25	36289	3	0	1	2	56
CRW_00613	Intron_gpI links to Rfam database...	0.42	0.22	0.81	17	34959	6	0	4	2	61
CRW_00614	Intron_gpI links to Rfam database...	0.45	0.32	0.64	18	121743	11	2	8	1	39
CRW_00618	Intron_gpI links to Rfam database...	0.39	0.26	0.59	16	56253	11	2	9	0	45
CRW_00633	Intron_gpI links to Rfam database...	0.40	0.21	0.76	22	63517	7	2	5	0	84
CRW_00634	Intron_gpI links to Rfam database...	0.37	0.18	0.74	17	64597	12	0	6	6	77
CRW_00670	Intron_gpI links to Rfam database...	0.48	0.24	0.97	29	70095	1	0	1	0	91
CRW_00671	Intron_gpI links to Rfam database...	0.49	0.25	0.97	29	62805	1	0	1	0	88
CRW_00672	Intron_gpI links to Rfam database...	0.50	0.26	0.97	29	72360	1	0	1	0	82
CRW_00674	Intron_gpI links to Rfam database...	0.29	0.14	0.63	17	83409	10	6	4	0	107
CRW_00676	Intron_gpI links to Rfam database...	0.32	0.15	0.68	17	93503	13	0	8	5	98
CRW_00692	Intron_gpI links to Rfam database...	0.34	0.17	0.68	15	68613	13	0	7	6	75
PDB_00827	Intron_gpI links to Rfam database...	0.35	0.21	0.59	17	26999	12	2	10	0	64
RFA_00606	Telomerase-cil links to Rfam database...	0.89	0.79	1.00	31	21290	0	0	0	0	8
RFA_00620	Telomerase-cil links to Rfam database...	0.88	0.77	1.00	30	21915	0	0	0	0	9
RFA_00626	rne5 links to Rfam database...	0.97	0.94	1.00	82	56534	6	0	0	6	5
RFA_00627	rne5 links to Rfam database...	0.96	0.93	1.00	81	56872	7	0	0	7	6
RFA_00628	rne5 links to Rfam database...	0.97	0.94	1.00	81	57210	6	0	0	6	5
RFA_00630	rne5 links to Rfam database...	0.92	0.87	0.96	76	56874	12	0	3	9	11
RFA_00639	7SK links to Rfam database...	0.22	0.14	0.36	12	54582	21	4	17	0	75
RFA_00814	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	25172	0	0	0	0	13
RFA_00815	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	24503	0	0	0	0	13
RFA_00816	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	23192	0	0	0	0	13
RFA_00817	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	21917	0	0	0	0	13
RFA_00818	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	20273	0	0	0	0	13
RFA_00819	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	27938	0	0	0	0	13
SRP_00016	Archaea_SRP links to Rfam database...	0.81	0.68	0.97	74	47819	5	0	2	3	35
SRP_00130	Archaea_SRP links to Rfam database...	0.73	0.63	0.86	61	49699	17	0	10	7	36
SRP_00142	Archaea_SRP links to Rfam database...	0.82	0.73	0.93	68	45983	10	0	5	5	25
SRP_00143	Archaea_SRP links to Rfam database...	0.74	0.62	0.88	63	49698	17	0	9	8	38
SRP_00144	Archaea_SRP links to Rfam database...	0.84	0.76	0.93	71	46589	9	0	5	4	23
SRP_00197	Archaea_SRP links to Rfam database...	0.83	0.72	0.96	73	49379	8	0	3	5	28
SRP_00198	Archaea_SRP links to Rfam database...	0.82	0.71	0.96	73	50964	8	0	3	5	30
SRP_00199	Archaea_SRP links to Rfam database...	0.82	0.70	0.96	73	50964	8	0	3	5	32
SRP_00201	Archaea_SRP links to Rfam database...	0.82	0.69	0.97	77	47816	3	0	2	1	34
SRP_00202	Archaea_SRP links to Rfam database...	0.78	0.64	0.96	75	54207	4	0	3	1	42
SRP_00203	Archaea_SRP links to Rfam database...	0.71	0.60	0.84	63	48753	15	0	12	3	42
SRP_00204	Archaea_SRP links to Rfam database...	0.80	0.68	0.95	69	49068	11	0	4	7	33
SRP_00206	Archaea_SRP links to Rfam database...	0.84	0.72	0.98	78	47815	3	0	2	1	30
SRP_00208	Archaea_SRP links to Rfam database...	0.80	0.67	0.96	68	46594	11	0	3	8	33
SRP_00255	Archaea_SRP links to Rfam database...	0.74	0.66	0.84	62	47512	18	0	12	6	32
SRP_00276	Archaea_SRP links to Rfam database...	0.83	0.70	0.97	77	50642	3	0	2	1	33
SRP_00278	Archaea_SRP links to Rfam database...	0.77	0.65	0.91	68	45981	9	0	7	2	37
SRP_00321	Archaea_SRP links to Rfam database...	0.80	0.67	0.96	72	47511	5	1	2	2	36
SRP_00322	Archaea_SRP links to Rfam database...	0.78	0.65	0.93	71	48440	7	0	5	2	38
SRP_00323	Archaea_SRP links to Rfam database...	0.82	0.69	0.97	74	47202	4	0	2	2	33
SRP_00330	Archaea_SRP links to Rfam database...	0.79	0.69	0.90	66	50013	13	0	7	6	29
SRP_00332	Archaea_SRP links to Rfam database...	0.84	0.72	0.97	76	50325	3	0	2	1	30
SRP_00339	Archaea_SRP links to Rfam database...	0.79	0.69	0.90	65	44479	10	0	7	3	29

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1249
Total TN	2623051
Total FP	419
Total FP CONTRA	30
Total FP INCONS	360
Total FP COMP	29
Total FN	3354

Total Scores
MCC	0.454
Average MCC ± 95% Confidence Intervals	0.456 ± 0.042
Sensitivity	0.271
Positive Predictive Value	0.762
Nr of predictions	51

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

2. Individual counts for RNAalifold(seed) [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]