CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

Home

Methods

Datasets

Rankings

RNA 2D Atlas

Help

FAQ

Contact us

RSS feeds

Twitter

Overview

Metric	RNAalifold(seed)		RNASampler(20)
MCC	0.639	>	0.578
Average MCC ± 95% Confidence Intervals	0.621 ± 0.046	>	0.525 ± 0.079
Sensitivity	0.436	>	0.384
Positive Predictive Value	0.937	>	0.871
Total TP	1674	>	1475
Total TN	1860133	<	1860227
Total FP	177	<	283
Total FP CONTRA	16	<	28
Total FP INCONS	97	<	190
Total FP COMP	64	<	65
Total FN	2164	<	2363
P-value	3.56938820447e-08

^top

Performance plots

Comparison of performance of RNAalifold(seed) and RNASampler(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and RNASampler(20)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(seed) and RNASampler(20)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and RNASampler(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and RNASampler(20)).

^top

Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP	1674
Total TN	1860133
Total FP	177
Total FP CONTRA	16
Total FP INCONS	97
Total FP COMP	64
Total FN	2164

Total Scores
MCC	0.639
Average MCC ± 95% Confidence Intervals	0.621 ± 0.046
Sensitivity	0.436
Positive Predictive Value	0.937
Nr of predictions	41

^top

2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.25	0.79	22	45423	6	1	5	0	67
ASE_00090	RNaseP_bact_a links to Rfam database...	0.42	0.23	0.79	23	55582	6	1	5	0	78
ASE_00135	RNaseP_bact_a links to Rfam database...	0.37	0.19	0.72	21	63161	8	1	7	0	88
ASE_00153	RNaseP_nuc links to Rfam database...	0.37	0.21	0.68	15	57608	7	0	7	0	58
ASE_00215	RNaseP_bact_a links to Rfam database...	0.36	0.17	0.74	17	48493	6	1	5	0	82
ASE_00305	RNaseP_bact_b links to Rfam database...	0.68	0.53	0.87	45	54563	12	1	6	5	40
ASE_00328	RNaseP_bact_b links to Rfam database...	0.69	0.54	0.90	60	72704	12	1	6	5	52
ASE_00361	RNaseP_bact_a links to Rfam database...	0.36	0.17	0.76	22	75437	7	2	5	0	105
ASE_00427	RNaseP_nuc links to Rfam database...	0.55	0.30	1.00	14	40741	0	0	0	0	32
ASE_00441	RNaseP_bact_a links to Rfam database...	0.38	0.19	0.78	21	64234	7	1	5	1	91
SRP_00006	Metazoa_SRP links to Rfam database...	0.76	0.59	0.98	60	45692	5	0	1	4	41
SRP_00011	Plant_SRP links to Rfam database...	0.68	0.52	0.90	54	46300	7	0	6	1	50
SRP_00015	Plant_SRP links to Rfam database...	0.72	0.54	0.96	53	46305	7	0	2	5	46
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.56	0.31	1.00	27	37648	0	0	0	0	60
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.55	0.31	1.00	27	36829	0	0	0	0	61
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.55	0.31	1.00	27	36829	0	0	0	0	61
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.54	0.29	1.00	26	36289	1	0	0	1	63
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.56	0.31	1.00	27	36558	0	0	0	0	60
SRP_00050	Metazoa_SRP links to Rfam database...	0.78	0.63	0.97	62	44786	3	0	2	1	37
SRP_00066	Metazoa_SRP links to Rfam database...	0.76	0.59	0.97	59	45390	6	0	2	4	41
SRP_00086	Metazoa_SRP links to Rfam database...	0.77	0.61	0.97	61	44190	4	0	2	2	39
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.55	0.30	1.00	27	34164	0	0	0	0	62
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.55	0.30	1.00	27	35751	0	0	0	0	63
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.55	0.30	1.00	27	35484	0	0	0	0	63
SRP_00102	Metazoa_SRP links to Rfam database...	0.77	0.61	0.97	62	44487	3	0	2	1	39
SRP_00103	Metazoa_SRP links to Rfam database...	0.77	0.62	0.97	63	45386	2	0	2	0	39
SRP_00152	Plant_SRP links to Rfam database...	0.76	0.57	1.00	59	45694	2	0	0	2	44
SRP_00171	Metazoa_SRP links to Rfam database...	0.78	0.63	0.98	55	45395	10	0	1	9	33
SRP_00178	Plant_SRP links to Rfam database...	0.75	0.57	1.00	58	45695	3	0	0	3	44
SRP_00179	Plant_SRP links to Rfam database...	0.74	0.54	1.00	57	45999	4	0	0	4	48
SRP_00181	Plant_SRP links to Rfam database...	0.66	0.49	0.88	50	45999	10	0	7	3	52
SRP_00182	Plant_SRP links to Rfam database...	0.73	0.55	0.95	56	45997	4	0	3	1	45
SRP_00188	Plant_SRP links to Rfam database...	0.77	0.66	0.91	52	31068	5	0	5	0	27
SRP_00228	Metazoa_SRP links to Rfam database...	0.80	0.65	0.98	62	45388	3	0	1	2	33
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.55	0.30	1.00	26	36289	1	0	0	1	60
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.55	0.31	1.00	27	36288	0	0	0	0	61
SRP_00317	Metazoa_SRP links to Rfam database...	0.78	0.63	0.97	62	45086	3	0	2	1	36
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.46	0.38	0.56	15	35218	12	7	5	0	24
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.54	0.30	1.00	27	35484	0	0	0	0	64
SRP_00347	Metazoa_SRP links to Rfam database...	0.77	0.60	0.98	58	46606	7	0	1	6	38
SRP_00368	Metazoa_SRP links to Rfam database...	0.78	0.62	0.97	61	43893	4	0	2	2	37

^top

Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	1475
Total TN	1860227
Total FP	283
Total FP CONTRA	28
Total FP INCONS	190
Total FP COMP	65
Total FN	2363

Total Scores
MCC	0.578
Average MCC ± 95% Confidence Intervals	0.525 ± 0.079
Sensitivity	0.384
Positive Predictive Value	0.871
Nr of predictions	41

^top

2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36585	0	0	0	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.40	0.16	1.00	14	34177	0	0	0	0	75
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35778	0	0	0	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	90
SRP_00102	Metazoa_SRP links to Rfam database...	0.86	0.77	0.95	78	44469	4	0	4	0	23
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00188	Plant_SRP links to Rfam database...	0.26	0.14	0.48	11	31102	12	1	11	0	68
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.47	0.23	0.95	20	36294	1	0	1	0	66
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36308	0	0	0	0	81
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.42	0.18	1.00	7	35238	0	0	0	0	32
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.38	0.14	1.00	13	35498	0	0	0	0	78
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40

^top

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

2. Individual counts for RNAalifold(seed) [ download as .csv ]

Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]