CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAfold		CMfinder(seed)
MCC	0.607	>	0.454
Average MCC ± 95% Confidence Intervals	0.601 ± 0.065	>	0.456 ± 0.042
Sensitivity	0.610	>	0.271
Positive Predictive Value	0.605	<	0.762
Total TP	2807	>	1249
Total TN	2620048	<	2623051
Total FP	2259	>	419
Total FP CONTRA	354	>	30
Total FP INCONS	1481	>	360
Total FP COMP	424	>	29
Total FN	1796	<	3354
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNAfold and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAfold and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAfold and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAfold and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAfold and CMfinder(seed)).

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Performance of RNAfold - scored higher in this pairwise comparison

1. Total counts & total scores for RNAfold

Total Base Pair Counts
Total TP	2807
Total TN	2620048
Total FP	2259
Total FP CONTRA	354
Total FP INCONS	1481
Total FP COMP	424
Total FN	1796

Total Scores
MCC	0.607
Average MCC ± 95% Confidence Intervals	0.601 ± 0.065
Sensitivity	0.610
Positive Predictive Value	0.605
Nr of predictions	51

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2. Individual counts for RNAfold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.21	0.22	0.21	25	103623	116	12	80	24	90
CRW_00016	Intron_gpI links to Rfam database...	0.64	0.62	0.67	74	77311	47	5	31	11	46
CRW_00610	Intron_gpI links to Rfam database...	0.21	0.21	0.22	17	36239	59	7	52	0	64
CRW_00613	Intron_gpI links to Rfam database...	0.65	0.60	0.70	47	34913	28	1	19	8	31
CRW_00614	Intron_gpI links to Rfam database...	0.16	0.19	0.14	11	121692	131	25	43	63	46
CRW_00618	Intron_gpI links to Rfam database...	0.12	0.13	0.12	8	56212	82	13	47	22	53
CRW_00633	Intron_gpI links to Rfam database...	0.44	0.43	0.45	46	63444	58	13	43	2	60
CRW_00634	Intron_gpI links to Rfam database...	0.50	0.52	0.49	49	64519	57	10	42	5	45
CRW_00670	Intron_gpI links to Rfam database...	0.69	0.68	0.71	82	70009	36	9	25	2	38
CRW_00671	Intron_gpI links to Rfam database...	0.60	0.59	0.61	69	62722	49	6	38	5	48
CRW_00672	Intron_gpI links to Rfam database...	0.48	0.50	0.47	55	72273	65	19	43	3	56
CRW_00674	Intron_gpI links to Rfam database...	0.53	0.53	0.52	66	83310	62	12	48	2	58
CRW_00676	Intron_gpI links to Rfam database...	0.54	0.56	0.52	64	93406	74	17	41	16	51
CRW_00692	Intron_gpI links to Rfam database...	0.40	0.42	0.38	38	68536	66	24	37	5	52
PDB_00827	Intron_gpI links to Rfam database...	0.50	0.46	0.55	37	26961	31	1	29	1	44
RFA_00606	Telomerase-cil links to Rfam database...	0.67	0.67	0.68	26	21283	25	7	5	13	13
RFA_00620	Telomerase-cil links to Rfam database...	0.64	0.62	0.67	24	21909	25	3	9	13	15
RFA_00626	rne5 links to Rfam database...	0.96	0.92	1.00	80	56536	25	0	0	25	7
RFA_00627	rne5 links to Rfam database...	0.72	0.69	0.75	60	56873	35	4	16	15	27
RFA_00628	rne5 links to Rfam database...	0.93	0.91	0.96	78	57210	29	0	3	26	8
RFA_00630	rne5 links to Rfam database...	0.66	0.66	0.66	57	56867	40	6	23	11	30
RFA_00639	7SK links to Rfam database...	0.17	0.18	0.16	16	54515	86	19	65	2	71
RFA_00814	R2_retro_el links to Rfam database...	0.79	0.80	0.77	33	25157	26	4	6	16	8
RFA_00815	R2_retro_el links to Rfam database...	0.65	0.71	0.60	29	24483	34	7	12	15	12
RFA_00816	R2_retro_el links to Rfam database...	0.59	0.66	0.53	27	23169	32	13	11	8	14
RFA_00817	R2_retro_el links to Rfam database...	0.10	0.12	0.08	5	21885	55	16	39	0	36
RFA_00818	R2_retro_el links to Rfam database...	0.59	0.63	0.55	26	20254	31	10	11	10	15
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	31	0	1	30	2
SRP_00016	Archaea_SRP links to Rfam database...	0.86	0.85	0.87	93	47788	16	2	12	2	16
SRP_00130	Archaea_SRP links to Rfam database...	0.24	0.24	0.24	23	49676	71	10	61	0	74
SRP_00142	Archaea_SRP links to Rfam database...	0.57	0.59	0.55	55	45956	48	7	38	3	38
SRP_00143	Archaea_SRP links to Rfam database...	0.86	0.85	0.86	86	49670	20	1	13	6	15
SRP_00144	Archaea_SRP links to Rfam database...	0.74	0.74	0.74	70	46571	31	1	23	7	24
SRP_00197	Archaea_SRP links to Rfam database...	0.49	0.48	0.51	48	49361	49	4	42	3	53
SRP_00198	Archaea_SRP links to Rfam database...	0.62	0.60	0.63	62	50942	40	2	34	4	41
SRP_00199	Archaea_SRP links to Rfam database...	0.26	0.26	0.26	27	50938	77	4	71	2	78
SRP_00201	Archaea_SRP links to Rfam database...	0.85	0.84	0.85	93	47786	18	5	11	2	18
SRP_00202	Archaea_SRP links to Rfam database...	0.85	0.85	0.85	99	54169	21	2	15	4	18
SRP_00203	Archaea_SRP links to Rfam database...	0.73	0.75	0.72	79	48718	37	3	28	6	26
SRP_00204	Archaea_SRP links to Rfam database...	0.78	0.77	0.78	79	49040	24	4	18	2	23
SRP_00206	Archaea_SRP links to Rfam database...	0.82	0.82	0.82	89	47786	21	5	15	1	19
SRP_00208	Archaea_SRP links to Rfam database...	0.67	0.67	0.67	68	46564	35	7	26	2	33
SRP_00255	Archaea_SRP links to Rfam database...	0.60	0.62	0.59	58	47487	47	3	38	6	36
SRP_00276	Archaea_SRP links to Rfam database...	0.86	0.85	0.86	94	50612	16	5	10	1	16
SRP_00278	Archaea_SRP links to Rfam database...	0.72	0.72	0.72	76	45950	32	4	26	2	29
SRP_00321	Archaea_SRP links to Rfam database...	0.77	0.77	0.78	83	47479	27	3	21	3	25
SRP_00322	Archaea_SRP links to Rfam database...	0.62	0.62	0.62	68	48406	43	5	37	1	41
SRP_00323	Archaea_SRP links to Rfam database...	0.92	0.92	0.93	98	47173	11	0	7	4	9
SRP_00330	Archaea_SRP links to Rfam database...	0.42	0.42	0.42	40	49991	58	2	53	3	55
SRP_00332	Archaea_SRP links to Rfam database...	0.80	0.81	0.80	86	50295	25	6	16	3	20
SRP_00339	Archaea_SRP links to Rfam database...	0.47	0.48	0.46	45	44453	57	6	47	4	49

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1249
Total TN	2623051
Total FP	419
Total FP CONTRA	30
Total FP INCONS	360
Total FP COMP	29
Total FN	3354

Total Scores
MCC	0.454
Average MCC ± 95% Confidence Intervals	0.456 ± 0.042
Sensitivity	0.271
Positive Predictive Value	0.762
Nr of predictions	51

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAfold - scored higher in this pairwise comparison

1. Total counts & total scores for RNAfold

2. Individual counts for RNAfold [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]