CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAshapes		CMfinder(seed)
MCC	0.560	>	0.457
Average MCC ± 95% Confidence Intervals	0.549 ± 0.059	>	0.457 ± 0.044
Sensitivity	0.558	>	0.274
Positive Predictive Value	0.564	<	0.762
Total TP	2422	>	1191
Total TN	2337928	<	2340663
Total FP	2174	>	393
Total FP CONTRA	277	>	27
Total FP INCONS	1599	>	345
Total FP COMP	298	>	21
Total FN	1922	<	3153
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNAshapes and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAshapes and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAshapes and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAshapes and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAshapes and CMfinder(seed)).

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Performance of RNAshapes - scored higher in this pairwise comparison

1. Total counts & total scores for RNAshapes

Total Base Pair Counts
Total TP	2422
Total TN	2337928
Total FP	2174
Total FP CONTRA	277
Total FP INCONS	1599
Total FP COMP	298
Total FN	1922

Total Scores
MCC	0.560
Average MCC ± 95% Confidence Intervals	0.549 ± 0.059
Sensitivity	0.558
Positive Predictive Value	0.564
Nr of predictions	48

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2. Individual counts for RNAshapes [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00016	Intron_gpI links to Rfam database...	0.49	0.48	0.51	57	77309	66	7	48	11	63
CRW_00610	Intron_gpI links to Rfam database...	0.55	0.53	0.57	43	36240	37	3	29	5	38
CRW_00613	Intron_gpI links to Rfam database...	0.64	0.58	0.70	45	34916	28	1	18	9	33
CRW_00618	Intron_gpI links to Rfam database...	0.17	0.18	0.16	11	56213	77	9	47	21	50
CRW_00633	Intron_gpI links to Rfam database...	0.55	0.54	0.56	57	63445	45	8	36	1	49
CRW_00634	Intron_gpI links to Rfam database...	0.33	0.34	0.33	32	64522	75	8	58	9	62
CRW_00670	Intron_gpI links to Rfam database...	0.74	0.72	0.76	86	70012	32	0	27	5	34
CRW_00671	Intron_gpI links to Rfam database...	0.65	0.62	0.67	73	62726	43	1	35	7	44
CRW_00672	Intron_gpI links to Rfam database...	0.66	0.66	0.66	73	72279	45	8	30	7	38
CRW_00674	Intron_gpI links to Rfam database...	0.68	0.67	0.69	83	83316	41	6	31	4	41
CRW_00676	Intron_gpI links to Rfam database...	0.58	0.62	0.55	71	93398	67	17	42	8	44
CRW_00692	Intron_gpI links to Rfam database...	0.43	0.46	0.40	41	68533	70	18	43	9	49
PDB_00827	Intron_gpI links to Rfam database...	0.64	0.56	0.74	45	26967	17	0	16	1	36
RFA_00606	Telomerase-cil links to Rfam database...	0.67	0.67	0.67	26	21282	32	1	12	19	13
RFA_00620	Telomerase-cil links to Rfam database...	0.44	0.46	0.42	18	21902	36	7	18	11	21
RFA_00626	rne5 links to Rfam database...	0.45	0.45	0.46	39	56531	61	9	37	15	48
RFA_00627	rne5 links to Rfam database...	0.63	0.61	0.66	53	56873	42	4	23	15	34
RFA_00628	rne5 links to Rfam database...	0.82	0.80	0.84	69	57209	33	1	12	20	17
RFA_00639	7SK links to Rfam database...	0.22	0.24	0.21	21	54515	82	20	59	3	66
RFA_00814	R2_retro_el links to Rfam database...	0.62	0.63	0.60	26	25157	26	6	11	9	15
RFA_00815	R2_retro_el links to Rfam database...	0.67	0.71	0.63	29	24485	31	1	16	14	12
RFA_00816	R2_retro_el links to Rfam database...	0.21	0.24	0.18	10	23164	47	18	28	1	31
RFA_00817	R2_retro_el links to Rfam database...	0.10	0.12	0.08	5	21881	60	21	38	1	36
RFA_00818	R2_retro_el links to Rfam database...	0.52	0.56	0.48	23	20253	31	9	16	6	18
RFA_00819	R2_retro_el links to Rfam database...	0.84	0.80	0.87	33	27928	36	0	5	31	8
SRP_00016	Archaea_SRP links to Rfam database...	0.76	0.74	0.78	81	47791	24	1	22	1	28
SRP_00130	Archaea_SRP links to Rfam database...	0.18	0.18	0.19	17	49679	74	10	64	0	80
SRP_00142	Archaea_SRP links to Rfam database...	0.16	0.16	0.15	15	45959	84	8	74	2	78
SRP_00143	Archaea_SRP links to Rfam database...	0.37	0.38	0.36	38	49664	70	6	62	2	63
SRP_00144	Archaea_SRP links to Rfam database...	0.39	0.38	0.39	36	46573	60	8	48	4	58
SRP_00197	Archaea_SRP links to Rfam database...	0.31	0.31	0.32	31	49358	67	4	62	1	70
SRP_00198	Archaea_SRP links to Rfam database...	0.46	0.45	0.47	46	50943	56	3	48	5	57
SRP_00199	Archaea_SRP links to Rfam database...	0.31	0.30	0.33	31	50945	67	3	61	3	74
SRP_00201	Archaea_SRP links to Rfam database...	0.80	0.76	0.84	84	47795	19	1	15	3	27
SRP_00202	Archaea_SRP links to Rfam database...	0.78	0.79	0.78	92	54167	30	3	23	4	25
SRP_00203	Archaea_SRP links to Rfam database...	0.64	0.64	0.64	67	48724	44	2	35	7	38
SRP_00204	Archaea_SRP links to Rfam database...	0.77	0.75	0.79	77	49043	22	5	16	1	25
SRP_00206	Archaea_SRP links to Rfam database...	0.76	0.74	0.78	80	47793	24	5	17	2	28
SRP_00208	Archaea_SRP links to Rfam database...	0.53	0.53	0.53	54	46563	49	10	38	1	47
SRP_00255	Archaea_SRP links to Rfam database...	0.59	0.60	0.58	56	47489	47	2	39	6	38
SRP_00276	Archaea_SRP links to Rfam database...	0.81	0.79	0.84	87	50617	18	0	17	1	23
SRP_00278	Archaea_SRP links to Rfam database...	0.70	0.69	0.72	72	45956	30	3	25	2	33
SRP_00321	Archaea_SRP links to Rfam database...	0.72	0.69	0.74	75	47485	28	3	23	2	33
SRP_00322	Archaea_SRP links to Rfam database...	0.57	0.55	0.58	60	48413	44	3	40	1	49
SRP_00323	Archaea_SRP links to Rfam database...	0.78	0.77	0.80	82	47176	23	0	20	3	25
SRP_00330	Archaea_SRP links to Rfam database...	0.41	0.42	0.40	40	49987	61	5	54	2	55
SRP_00332	Archaea_SRP links to Rfam database...	0.80	0.77	0.82	82	50303	19	1	17	1	24
SRP_00339	Archaea_SRP links to Rfam database...	0.51	0.53	0.49	50	44449	54	8	44	2	44

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1191
Total TN	2340663
Total FP	393
Total FP CONTRA	27
Total FP INCONS	345
Total FP COMP	21
Total FN	3153

Total Scores
MCC	0.457
Average MCC ± 95% Confidence Intervals	0.457 ± 0.044
Sensitivity	0.274
Positive Predictive Value	0.762
Nr of predictions	48

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAshapes - scored higher in this pairwise comparison

1. Total counts & total scores for RNAshapes

2. Individual counts for RNAshapes [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]