CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

Home

Methods

Datasets

Rankings

RNA 2D Atlas

Help

FAQ

Contact us

RSS feeds

Twitter

Overview

Metric	RNAsubopt		CMfinder(seed)
MCC	0.602	>	0.454
Average MCC ± 95% Confidence Intervals	0.594 ± 0.059	>	0.456 ± 0.042
Sensitivity	0.612	>	0.271
Positive Predictive Value	0.595	<	0.762
Total TP	2815	>	1249
Total TN	2619956	<	2623051
Total FP	2352	>	419
Total FP CONTRA	344	>	30
Total FP INCONS	1575	>	360
Total FP COMP	433	>	29
Total FN	1788	<	3354
P-value	3.56938820447e-08

^top

Performance plots

Comparison of performance of RNAsubopt and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAsubopt and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAsubopt and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAsubopt and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAsubopt and CMfinder(seed)).

^top

Performance of RNAsubopt - scored higher in this pairwise comparison

1. Total counts & total scores for RNAsubopt

Total Base Pair Counts
Total TP	2815
Total TN	2619956
Total FP	2352
Total FP CONTRA	344
Total FP INCONS	1575
Total FP COMP	433
Total FN	1788

Total Scores
MCC	0.602
Average MCC ± 95% Confidence Intervals	0.594 ± 0.059
Sensitivity	0.612
Positive Predictive Value	0.595
Nr of predictions	51

^top

2. Individual counts for RNAsubopt [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.21	0.22	0.21	25	103620	117	13	82	22	90
CRW_00016	Intron_gpI links to Rfam database...	0.60	0.58	0.63	70	77309	55	5	37	13	50
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.51	0.48	41	36230	44	9	35	0	40
CRW_00613	Intron_gpI links to Rfam database...	0.66	0.62	0.71	48	34912	28	1	19	8	30
CRW_00614	Intron_gpI links to Rfam database...	0.16	0.19	0.13	11	121684	137	27	49	61	46
CRW_00618	Intron_gpI links to Rfam database...	0.07	0.08	0.07	5	56205	92	15	55	22	56
CRW_00633	Intron_gpI links to Rfam database...	0.40	0.42	0.39	44	63434	70	10	58	2	62
CRW_00634	Intron_gpI links to Rfam database...	0.50	0.53	0.48	50	64516	59	11	43	5	44
CRW_00670	Intron_gpI links to Rfam database...	0.62	0.61	0.63	73	70009	45	9	34	2	47
CRW_00671	Intron_gpI links to Rfam database...	0.65	0.63	0.67	74	62725	43	1	35	7	43
CRW_00672	Intron_gpI links to Rfam database...	0.74	0.75	0.74	83	72278	38	6	23	9	28
CRW_00674	Intron_gpI links to Rfam database...	0.60	0.61	0.59	76	83308	55	10	42	3	48
CRW_00676	Intron_gpI links to Rfam database...	0.56	0.58	0.54	67	93403	71	15	43	13	48
CRW_00692	Intron_gpI links to Rfam database...	0.34	0.37	0.32	33	68532	80	22	48	10	57
PDB_00827	Intron_gpI links to Rfam database...	0.59	0.53	0.65	43	26962	24	3	20	1	38
RFA_00606	Telomerase-cil links to Rfam database...	0.63	0.67	0.60	26	21278	33	8	9	16	13
RFA_00620	Telomerase-cil links to Rfam database...	0.46	0.46	0.46	18	21906	36	7	14	15	21
RFA_00626	rne5 links to Rfam database...	0.68	0.66	0.70	57	56535	42	6	18	18	30
RFA_00627	rne5 links to Rfam database...	0.72	0.68	0.77	59	56876	33	4	14	15	28
RFA_00628	rne5 links to Rfam database...	0.89	0.86	0.91	74	57210	32	2	5	25	12
RFA_00630	rne5 links to Rfam database...	0.58	0.60	0.57	52	56861	51	12	28	11	35
RFA_00639	7SK links to Rfam database...	0.22	0.24	0.20	21	54512	86	20	62	4	66
RFA_00814	R2_retro_el links to Rfam database...	0.39	0.39	0.39	16	25159	40	5	20	15	25
RFA_00815	R2_retro_el links to Rfam database...	0.65	0.71	0.59	29	24482	35	5	15	15	12
RFA_00816	R2_retro_el links to Rfam database...	0.74	0.78	0.70	32	23174	24	8	6	10	9
RFA_00817	R2_retro_el links to Rfam database...	0.35	0.41	0.30	17	21889	43	11	28	4	24
RFA_00818	R2_retro_el links to Rfam database...	0.47	0.54	0.41	22	20247	39	13	19	7	19
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	31	0	1	30	2
SRP_00016	Archaea_SRP links to Rfam database...	0.86	0.84	0.88	92	47790	15	2	11	2	17
SRP_00130	Archaea_SRP links to Rfam database...	0.39	0.40	0.38	39	49667	64	9	55	0	58
SRP_00142	Archaea_SRP links to Rfam database...	0.40	0.42	0.39	39	45955	64	6	56	2	54
SRP_00143	Archaea_SRP links to Rfam database...	0.86	0.85	0.86	86	49670	20	1	13	6	15
SRP_00144	Archaea_SRP links to Rfam database...	0.73	0.74	0.72	70	46568	34	1	26	7	24
SRP_00197	Archaea_SRP links to Rfam database...	0.49	0.49	0.49	49	49355	54	3	48	3	52
SRP_00198	Archaea_SRP links to Rfam database...	0.63	0.62	0.65	64	50941	39	2	33	4	39
SRP_00199	Archaea_SRP links to Rfam database...	0.26	0.26	0.26	27	50938	77	4	71	2	78
SRP_00201	Archaea_SRP links to Rfam database...	0.90	0.87	0.92	97	47790	10	0	8	2	14
SRP_00202	Archaea_SRP links to Rfam database...	0.85	0.84	0.86	98	54171	20	0	16	4	19
SRP_00203	Archaea_SRP links to Rfam database...	0.80	0.82	0.79	86	48719	29	1	22	6	19
SRP_00204	Archaea_SRP links to Rfam database...	0.60	0.61	0.60	62	49037	43	7	35	1	40
SRP_00206	Archaea_SRP links to Rfam database...	0.84	0.84	0.84	91	47787	18	6	11	1	17
SRP_00208	Archaea_SRP links to Rfam database...	0.68	0.68	0.68	69	46564	34	7	25	2	32
SRP_00255	Archaea_SRP links to Rfam database...	0.62	0.64	0.61	60	47487	46	3	36	7	34
SRP_00276	Archaea_SRP links to Rfam database...	0.86	0.85	0.86	94	50612	16	5	10	1	16
SRP_00278	Archaea_SRP links to Rfam database...	0.71	0.71	0.70	75	45949	34	2	30	2	30
SRP_00321	Archaea_SRP links to Rfam database...	0.70	0.71	0.68	77	47473	38	7	29	2	31
SRP_00322	Archaea_SRP links to Rfam database...	0.62	0.62	0.62	68	48406	43	5	37	1	41
SRP_00323	Archaea_SRP links to Rfam database...	0.93	0.93	0.93	100	47171	11	0	7	4	7
SRP_00330	Archaea_SRP links to Rfam database...	0.38	0.41	0.36	39	49978	70	6	63	1	56
SRP_00332	Archaea_SRP links to Rfam database...	0.71	0.72	0.70	76	50295	38	3	29	6	30
SRP_00339	Archaea_SRP links to Rfam database...	0.54	0.55	0.52	52	44451	52	6	42	4	42

^top

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1249
Total TN	2623051
Total FP	419
Total FP CONTRA	30
Total FP INCONS	360
Total FP COMP	29
Total FN	3354

Total Scores
MCC	0.454
Average MCC ± 95% Confidence Intervals	0.456 ± 0.042
Sensitivity	0.271
Positive Predictive Value	0.762
Nr of predictions	51

^top

2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

^top

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAsubopt - scored higher in this pairwise comparison

1. Total counts & total scores for RNAsubopt

2. Individual counts for RNAsubopt [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]