CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAsubopt		Murlet(seed)
MCC	0.606	>	0.556
Average MCC ± 95% Confidence Intervals	0.604 ± 0.064	>	0.543 ± 0.095
Sensitivity	0.619	>	0.366
Positive Predictive Value	0.595	<	0.846
Total TP	1419	>	840
Total TN	1198893	<	1200285
Total FP	1205	>	205
Total FP CONTRA	181	>	9
Total FP INCONS	785	>	144
Total FP COMP	239	>	52
Total FN	875	<	1454
P-value	5.10776592382e-08

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Performance plots

Comparison of performance of RNAsubopt and Murlet(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAsubopt and Murlet(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAsubopt and Murlet(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAsubopt and Murlet(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAsubopt and Murlet(seed)).

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Performance of RNAsubopt - scored higher in this pairwise comparison

1. Total counts & total scores for RNAsubopt

Total Base Pair Counts
Total TP	1419
Total TN	1198893
Total FP	1205
Total FP CONTRA	181
Total FP INCONS	785
Total FP COMP	239
Total FN	875

Total Scores
MCC	0.606
Average MCC ± 95% Confidence Intervals	0.604 ± 0.064
Sensitivity	0.619
Positive Predictive Value	0.595
Nr of predictions	29

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2. Individual counts for RNAsubopt [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.63	0.67	0.60	26	21278	33	8	9	16	13
RFA_00620	Telomerase-cil links to Rfam database...	0.46	0.46	0.46	18	21906	36	7	14	15	21
RFA_00626	rne5 links to Rfam database...	0.68	0.66	0.70	57	56535	42	6	18	18	30
RFA_00627	rne5 links to Rfam database...	0.72	0.68	0.77	59	56876	33	4	14	15	28
RFA_00628	rne5 links to Rfam database...	0.89	0.86	0.91	74	57210	32	2	5	25	12
RFA_00630	rne5 links to Rfam database...	0.58	0.60	0.57	52	56861	51	12	28	11	35
RFA_00639	7SK links to Rfam database...	0.22	0.24	0.20	21	54512	86	20	62	4	66
RFA_00814	R2_retro_el links to Rfam database...	0.39	0.39	0.39	16	25159	40	5	20	15	25
RFA_00815	R2_retro_el links to Rfam database...	0.65	0.71	0.59	29	24482	35	5	15	15	12
RFA_00816	R2_retro_el links to Rfam database...	0.74	0.78	0.70	32	23174	24	8	6	10	9
RFA_00817	R2_retro_el links to Rfam database...	0.35	0.41	0.30	17	21889	43	11	28	4	24
RFA_00818	R2_retro_el links to Rfam database...	0.47	0.54	0.41	22	20247	39	13	19	7	19
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	31	0	1	30	2
SRP_00079	Plant_SRP links to Rfam database...	0.71	0.73	0.70	64	41813	35	4	24	7	24
SRP_00124	Metazoa_SRP links to Rfam database...	0.67	0.67	0.68	57	37044	30	4	23	3	28
SRP_00182	Plant_SRP links to Rfam database...	0.70	0.68	0.71	69	45959	31	2	26	3	32
SRP_00197	Archaea_SRP links to Rfam database...	0.49	0.49	0.49	49	49355	54	3	48	3	52
SRP_00198	Archaea_SRP links to Rfam database...	0.63	0.62	0.65	64	50941	39	2	33	4	39
SRP_00199	Archaea_SRP links to Rfam database...	0.26	0.26	0.26	27	50938	77	4	71	2	78
SRP_00202	Archaea_SRP links to Rfam database...	0.85	0.84	0.86	98	54171	20	0	16	4	19
SRP_00241	Plant_SRP links to Rfam database...	0.55	0.59	0.52	48	45963	48	12	33	3	34
SRP_00255	Archaea_SRP links to Rfam database...	0.62	0.64	0.61	60	47487	46	3	36	7	34
SRP_00260	Metazoa_SRP links to Rfam database...	0.64	0.69	0.60	69	47780	48	7	39	2	31
SRP_00278	Archaea_SRP links to Rfam database...	0.71	0.71	0.70	75	45949	34	2	30	2	30
SRP_00322	Archaea_SRP links to Rfam database...	0.62	0.62	0.62	68	48406	43	5	37	1	41
SRP_00328	Metazoa_SRP links to Rfam database...	0.64	0.66	0.63	56	39532	38	8	25	5	29
SRP_00329	Metazoa_SRP links to Rfam database...	0.61	0.62	0.60	53	39814	37	10	26	1	32
SRP_00339	Archaea_SRP links to Rfam database...	0.54	0.55	0.52	52	44451	52	6	42	4	42
SRP_00340	Metazoa_SRP links to Rfam database...	0.55	0.59	0.52	48	41235	48	8	37	3	34

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Performance of Murlet(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP	840
Total TN	1200285
Total FP	205
Total FP CONTRA	9
Total FP INCONS	144
Total FP COMP	52
Total FN	1454

Total Scores
MCC	0.556
Average MCC ± 95% Confidence Intervals	0.543 ± 0.095
Sensitivity	0.366
Positive Predictive Value	0.846
Nr of predictions	29

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21321	0	0	0	0	39
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21945	0	0	0	0	39
RFA_00626	rne5 links to Rfam database...	0.81	0.66	1.00	57	56559	4	0	0	4	30
RFA_00627	rne5 links to Rfam database...	0.84	0.70	1.00	61	56892	5	0	0	5	26
RFA_00628	rne5 links to Rfam database...	0.83	0.69	1.00	59	57232	8	0	0	8	27
RFA_00630	rne5 links to Rfam database...	0.82	0.67	1.00	58	56895	4	0	0	4	29
RFA_00639	7SK links to Rfam database...	0.21	0.11	0.40	10	54590	15	4	11	0	77
RFA_00814	R2_retro_el links to Rfam database...	0.75	0.63	0.90	26	25171	4	0	3	1	15
RFA_00815	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	24503	1	0	0	1	13
RFA_00816	R2_retro_el links to Rfam database...	0.75	0.63	0.90	26	23191	4	0	3	1	15
RFA_00817	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	21917	1	0	0	1	13
RFA_00818	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	20273	1	0	0	1	13
RFA_00819	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	27938	0	0	0	0	13
SRP_00079	Plant_SRP links to Rfam database...	0.54	0.33	0.88	29	41872	6	0	4	2	59
SRP_00124	Metazoa_SRP links to Rfam database...	0.15	0.09	0.24	8	37094	27	3	23	1	77
SRP_00182	Plant_SRP links to Rfam database...	0.59	0.35	1.00	35	46021	1	0	0	1	66
SRP_00197	Archaea_SRP links to Rfam database...	0.47	0.28	0.80	28	49420	8	0	7	1	73
SRP_00198	Archaea_SRP links to Rfam database...	0.47	0.27	0.82	28	51006	7	0	6	1	75
SRP_00199	Archaea_SRP links to Rfam database...	0.47	0.24	0.93	25	51013	3	0	2	1	80
SRP_00202	Archaea_SRP links to Rfam database...	0.48	0.25	0.94	29	54254	2	0	2	0	88
SRP_00241	Plant_SRP links to Rfam database...	0.51	0.33	0.79	27	46022	9	0	7	2	55
SRP_00255	Archaea_SRP links to Rfam database...	0.65	0.43	1.00	40	47546	2	0	0	2	54
SRP_00260	Metazoa_SRP links to Rfam database...	0.21	0.14	0.33	14	47852	29	1	28	0	86
SRP_00278	Archaea_SRP links to Rfam database...	0.53	0.30	0.94	31	46023	3	0	2	1	74
SRP_00322	Archaea_SRP links to Rfam database...	0.44	0.25	0.79	27	48482	8	0	7	1	82
SRP_00328	Metazoa_SRP links to Rfam database...	0.49	0.34	0.71	29	39580	16	1	11	4	56
SRP_00329	Metazoa_SRP links to Rfam database...	0.50	0.34	0.73	29	39863	16	0	11	5	56
SRP_00339	Archaea_SRP links to Rfam database...	0.49	0.32	0.77	30	44512	9	0	9	0	64
SRP_00340	Metazoa_SRP links to Rfam database...	0.44	0.27	0.73	22	41298	12	0	8	4	60

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAsubopt - scored higher in this pairwise comparison

1. Total counts & total scores for RNAsubopt

2. Individual counts for RNAsubopt [ download as .csv ]

Performance of Murlet(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

2. Individual counts for Murlet(seed) [ download as .csv ]