CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RSpredict(seed)		CMfinder(seed)
MCC	0.475	>	0.454
Average MCC ± 95% Confidence Intervals	0.411 ± 0.093	<	0.456 ± 0.042
Sensitivity	0.307	>	0.271
Positive Predictive Value	0.738	<	0.762
Total TP	1411	>	1249
Total TN	2622779	<	2623051
Total FP	656	>	419
Total FP CONTRA	29	<	30
Total FP INCONS	471	>	360
Total FP COMP	156	>	29
Total FN	3192	<	3354
P-value	6.06606238843e-08

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Performance plots

Comparison of performance of RSpredict(seed) and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RSpredict(seed) and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RSpredict(seed) and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RSpredict(seed) and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RSpredict(seed) and CMfinder(seed)).

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Performance of RSpredict(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP	1411
Total TN	2622779
Total FP	656
Total FP CONTRA	29
Total FP INCONS	471
Total FP COMP	156
Total FN	3192

Total Scores
MCC	0.475
Average MCC ± 95% Confidence Intervals	0.411 ± 0.093
Sensitivity	0.307
Positive Predictive Value	0.738
Nr of predictions	51

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	103737	3	0	3	0	115
CRW_00016	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	77418	3	0	3	0	120
CRW_00610	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	36310	5	0	5	0	81
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34979	1	0	1	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121764	17	0	7	10	57
CRW_00618	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	56279	1	0	1	0	61
CRW_00633	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	63541	5	0	5	0	106
CRW_00634	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	64620	1	0	0	1	94
CRW_00670	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	70124	4	0	1	3	120
CRW_00671	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	117
CRW_00672	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	72386	7	0	4	3	111
CRW_00674	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	83436	1	0	0	1	124
CRW_00676	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	93527	2	0	1	1	115
CRW_00692	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	68635	3	0	0	3	90
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27026	2	0	2	0	81
RFA_00606	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21309	12	3	9	0	39
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21941	4	0	4	0	39
RFA_00626	rne5 links to Rfam database...	0.90	0.80	1.00	70	56546	12	0	0	12	17
RFA_00627	rne5 links to Rfam database...	0.90	0.82	0.99	71	56881	11	0	1	10	16
RFA_00628	rne5 links to Rfam database...	0.89	0.81	0.97	70	57219	12	0	2	10	16
RFA_00630	rne5 links to Rfam database...	0.85	0.75	0.97	65	56886	11	0	2	9	22
RFA_00639	7SK links to Rfam database...	0.59	0.48	0.72	42	54557	30	3	13	14	45
RFA_00814	R2_retro_el links to Rfam database...	0.90	0.85	0.95	35	25163	11	0	2	9	6
RFA_00815	R2_retro_el links to Rfam database...	0.90	0.85	0.95	35	24494	10	0	2	8	6
RFA_00816	R2_retro_el links to Rfam database...	0.90	0.85	0.95	35	23183	8	0	2	6	6
RFA_00817	R2_retro_el links to Rfam database...	0.88	0.83	0.94	34	21909	7	0	2	5	7
RFA_00818	R2_retro_el links to Rfam database...	0.80	0.71	0.91	29	20269	10	0	3	7	12
RFA_00819	R2_retro_el links to Rfam database...	0.90	0.85	0.95	35	27929	13	0	2	11	6
SRP_00016	Archaea_SRP links to Rfam database...	0.58	0.41	0.82	45	47840	11	0	10	1	64
SRP_00130	Archaea_SRP links to Rfam database...	0.43	0.31	0.60	30	49720	22	2	18	2	67
SRP_00142	Archaea_SRP links to Rfam database...	0.55	0.42	0.74	39	46003	17	0	14	3	54
SRP_00143	Archaea_SRP links to Rfam database...	0.56	0.45	0.70	45	49706	20	0	19	1	56
SRP_00144	Archaea_SRP links to Rfam database...	0.55	0.43	0.70	40	46608	20	1	16	3	54
SRP_00197	Archaea_SRP links to Rfam database...	0.51	0.37	0.73	37	49404	15	3	11	1	64
SRP_00198	Archaea_SRP links to Rfam database...	0.52	0.39	0.70	40	50983	20	2	15	3	63
SRP_00199	Archaea_SRP links to Rfam database...	0.48	0.37	0.63	39	50978	24	0	23	1	66
SRP_00201	Archaea_SRP links to Rfam database...	0.51	0.39	0.68	43	47832	21	0	20	1	68
SRP_00202	Archaea_SRP links to Rfam database...	0.46	0.36	0.58	42	54213	31	2	28	1	75
SRP_00203	Archaea_SRP links to Rfam database...	0.41	0.31	0.54	33	48767	30	1	27	2	72
SRP_00204	Archaea_SRP links to Rfam database...	0.56	0.42	0.74	43	49083	17	1	14	2	59
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.41	0.73	44	47835	17	0	16	1	64
SRP_00208	Archaea_SRP links to Rfam database...	0.44	0.32	0.60	32	46612	21	2	19	0	69
SRP_00255	Archaea_SRP links to Rfam database...	0.52	0.38	0.71	36	47535	17	2	13	2	58
SRP_00276	Archaea_SRP links to Rfam database...	0.62	0.48	0.79	53	50654	15	1	13	1	57
SRP_00278	Archaea_SRP links to Rfam database...	0.48	0.35	0.65	37	45999	21	1	19	1	68
SRP_00321	Archaea_SRP links to Rfam database...	0.37	0.25	0.56	27	47538	22	1	20	1	81
SRP_00322	Archaea_SRP links to Rfam database...	0.47	0.34	0.66	37	48460	20	2	17	1	72
SRP_00323	Archaea_SRP links to Rfam database...	0.53	0.36	0.76	39	47227	13	0	12	1	68
SRP_00330	Archaea_SRP links to Rfam database...	0.38	0.25	0.57	24	50044	20	1	17	2	71
SRP_00332	Archaea_SRP links to Rfam database...	0.70	0.58	0.86	61	50332	11	0	10	1	45
SRP_00339	Archaea_SRP links to Rfam database...	0.36	0.26	0.50	24	44503	25	1	23	1	70

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1249
Total TN	2623051
Total FP	419
Total FP CONTRA	30
Total FP INCONS	360
Total FP COMP	29
Total FN	3354

Total Scores
MCC	0.454
Average MCC ± 95% Confidence Intervals	0.456 ± 0.042
Sensitivity	0.271
Positive Predictive Value	0.762
Nr of predictions	51

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RSpredict(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

2. Individual counts for RSpredict(seed) [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]