CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	RSpredict(seed)		RNASampler(seed)
MCC	0.816	>	0.779
Average MCC ± 95% Confidence Intervals	0.734 ± 0.219	<	0.774 ± 0.092
Sensitivity	0.714	>	0.659
Positive Predictive Value	0.934	>	0.921
Total TP	479	>	442
Total TN	413729	<	413762
Total FP	121	>	105
Total FP CONTRA	3	<	9
Total FP INCONS	31	>	29
Total FP COMP	87	>	67
Total FN	192	<	229
P-value	1.30295446166e-08

Comparison of performance of RSpredict(seed) and RNASampler(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RSpredict(seed) and RNASampler(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RSpredict(seed) and RNASampler(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RSpredict(seed) and RNASampler(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RSpredict(seed) and RNASampler(seed)).

Total Scores
MCC	0.816
Average MCC ± 95% Confidence Intervals	0.734 ± 0.219
Sensitivity	0.714
Positive Predictive Value	0.934
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21309	12	3	9	0	39
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21941	4	0	4	0	39
RFA_00626	rne5 links to Rfam database...	0.90	0.80	1.00	70	56546	12	0	0	12	17
RFA_00627	rne5 links to Rfam database...	0.90	0.82	0.99	71	56881	11	0	1	10	16
RFA_00628	rne5 links to Rfam database...	0.89	0.81	0.97	70	57219	12	0	2	10	16
RFA_00630	rne5 links to Rfam database...	0.85	0.75	0.97	65	56886	11	0	2	9	22
RFA_00814	R2_retro_el links to Rfam database...	0.90	0.85	0.95	35	25163	11	0	2	9	6
RFA_00815	R2_retro_el links to Rfam database...	0.90	0.85	0.95	35	24494	10	0	2	8	6
RFA_00816	R2_retro_el links to Rfam database...	0.90	0.85	0.95	35	23183	8	0	2	6	6
RFA_00817	R2_retro_el links to Rfam database...	0.88	0.83	0.94	34	21909	7	0	2	5	7
RFA_00818	R2_retro_el links to Rfam database...	0.80	0.71	0.91	29	20269	10	0	3	7	12
RFA_00819	R2_retro_el links to Rfam database...	0.90	0.85	0.95	35	27929	13	0	2	11	6

Total Scores
MCC	0.779
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092
Sensitivity	0.659
Positive Predictive Value	0.921
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.44	0.36	0.54	14	21295	18	7	5	6	25
RFA_00620	Telomerase-cil links to Rfam database...	0.52	0.44	0.63	17	21918	15	2	8	5	22
RFA_00626	rne5 links to Rfam database...	0.80	0.64	1.00	56	56560	5	0	0	5	31
RFA_00627	rne5 links to Rfam database...	0.77	0.63	0.93	55	56894	8	0	4	4	32
RFA_00628	rne5 links to Rfam database...	0.78	0.64	0.95	55	57233	12	0	3	9	31
RFA_00630	rne5 links to Rfam database...	0.77	0.66	0.90	57	56890	15	0	6	9	30
RFA_00814	R2_retro_el links to Rfam database...	0.87	0.78	0.97	32	25167	6	0	1	5	9
RFA_00815	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	24499	8	0	0	8	9
RFA_00816	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	23188	6	0	1	5	10
RFA_00817	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	21913	1	0	1	0	10
RFA_00818	R2_retro_el links to Rfam database...	0.86	0.73	1.00	30	20271	6	0	0	6	11
RFA_00819	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	27934	5	0	0	5	9

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.