CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Sfold		CMfinder(seed)
MCC	0.677	>	0.454
Average MCC ± 95% Confidence Intervals	0.654 ± 0.059	>	0.456 ± 0.042
Sensitivity	0.626	>	0.271
Positive Predictive Value	0.733	<	0.762
Total TP	2880	>	1249
Total TN	2620763	<	2623051
Total FP	1394	>	419
Total FP CONTRA	215	>	30
Total FP INCONS	832	>	360
Total FP COMP	347	>	29
Total FN	1723	<	3354
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Sfold and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Sfold and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Sfold and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Sfold and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Sfold and CMfinder(seed)).

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Performance of Sfold - scored higher in this pairwise comparison

1. Total counts & total scores for Sfold

Total Base Pair Counts
Total TP	2880
Total TN	2620763
Total FP	1394
Total FP CONTRA	215
Total FP INCONS	832
Total FP COMP	347
Total FN	1723

Total Scores
MCC	0.677
Average MCC ± 95% Confidence Intervals	0.654 ± 0.059
Sensitivity	0.626
Positive Predictive Value	0.733
Nr of predictions	51

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2. Individual counts for Sfold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.36	0.27	0.48	31	103675	57	8	26	23	84
CRW_00016	Intron_gpI links to Rfam database...	0.80	0.65	0.98	78	77341	14	0	2	12	42
CRW_00610	Intron_gpI links to Rfam database...	0.51	0.49	0.52	40	36238	37	9	28	0	41
CRW_00613	Intron_gpI links to Rfam database...	0.74	0.67	0.83	52	34917	19	0	11	8	26
CRW_00614	Intron_gpI links to Rfam database...	0.19	0.19	0.19	11	121713	102	12	35	55	46
CRW_00618	Intron_gpI links to Rfam database...	0.13	0.13	0.14	8	56223	68	13	36	19	53
CRW_00633	Intron_gpI links to Rfam database...	0.65	0.49	0.85	52	63485	11	2	7	2	54
CRW_00634	Intron_gpI links to Rfam database...	0.54	0.51	0.58	48	64537	40	6	29	5	46
CRW_00670	Intron_gpI links to Rfam database...	0.80	0.74	0.87	89	70023	15	6	7	2	31
CRW_00671	Intron_gpI links to Rfam database...	0.75	0.70	0.81	82	62734	23	5	14	4	35
CRW_00672	Intron_gpI links to Rfam database...	0.78	0.71	0.85	79	72297	20	6	8	6	32
CRW_00674	Intron_gpI links to Rfam database...	0.60	0.54	0.66	67	83335	36	6	28	2	57
CRW_00676	Intron_gpI links to Rfam database...	0.61	0.57	0.66	65	93430	48	9	24	15	50
CRW_00692	Intron_gpI links to Rfam database...	0.54	0.42	0.69	38	68580	27	6	11	10	52
PDB_00827	Intron_gpI links to Rfam database...	0.64	0.47	0.86	38	26984	8	0	6	2	43
RFA_00606	Telomerase-cil links to Rfam database...	0.65	0.59	0.72	23	21289	19	7	2	10	16
RFA_00620	Telomerase-cil links to Rfam database...	0.55	0.49	0.63	19	21915	22	3	8	11	20
RFA_00626	rne5 links to Rfam database...	0.89	0.84	0.95	73	56539	20	1	3	16	14
RFA_00627	rne5 links to Rfam database...	0.72	0.68	0.77	59	56876	30	4	14	12	28
RFA_00628	rne5 links to Rfam database...	0.90	0.86	0.95	74	57213	28	0	4	24	12
RFA_00630	rne5 links to Rfam database...	0.61	0.59	0.65	51	56874	38	7	21	10	36
RFA_00639	7SK links to Rfam database...	0.27	0.24	0.30	21	54546	53	9	39	5	66
RFA_00814	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	25168	10	0	1	9	10
RFA_00815	R2_retro_el links to Rfam database...	0.61	0.61	0.61	25	24490	21	6	10	5	16
RFA_00816	R2_retro_el links to Rfam database...	0.76	0.73	0.79	30	23182	12	8	0	4	11
RFA_00817	R2_retro_el links to Rfam database...	0.11	0.12	0.11	5	21899	41	14	27	0	36
RFA_00818	R2_retro_el links to Rfam database...	0.31	0.22	0.43	9	20280	13	8	4	1	32
RFA_00819	R2_retro_el links to Rfam database...	0.88	0.80	0.97	33	27932	25	0	1	24	8
SRP_00016	Archaea_SRP links to Rfam database...	0.92	0.89	0.95	97	47793	7	0	5	2	12
SRP_00130	Archaea_SRP links to Rfam database...	0.36	0.32	0.40	31	49693	46	7	39	0	66
SRP_00142	Archaea_SRP links to Rfam database...	0.63	0.59	0.68	55	45975	28	2	24	2	38
SRP_00143	Archaea_SRP links to Rfam database...	0.80	0.78	0.81	79	49673	25	1	17	7	22
SRP_00144	Archaea_SRP links to Rfam database...	0.74	0.73	0.75	69	46573	27	1	22	4	25
SRP_00197	Archaea_SRP links to Rfam database...	0.43	0.37	0.51	37	49382	36	1	35	0	64
SRP_00198	Archaea_SRP links to Rfam database...	0.42	0.35	0.51	36	50970	35	2	32	1	67
SRP_00199	Archaea_SRP links to Rfam database...	0.78	0.72	0.84	76	50950	15	0	14	1	29
SRP_00201	Archaea_SRP links to Rfam database...	0.87	0.84	0.89	93	47791	13	5	6	2	18
SRP_00202	Archaea_SRP links to Rfam database...	0.91	0.86	0.95	101	54179	7	0	5	2	16
SRP_00203	Archaea_SRP links to Rfam database...	0.80	0.81	0.79	85	48720	29	1	22	6	20
SRP_00204	Archaea_SRP links to Rfam database...	0.67	0.66	0.68	67	49043	32	6	25	1	35
SRP_00206	Archaea_SRP links to Rfam database...	0.84	0.83	0.85	90	47789	17	5	11	1	18
SRP_00208	Archaea_SRP links to Rfam database...	0.71	0.64	0.79	65	46583	18	2	15	1	36
SRP_00255	Archaea_SRP links to Rfam database...	0.62	0.62	0.62	58	47492	40	3	33	4	36
SRP_00276	Archaea_SRP links to Rfam database...	0.87	0.85	0.89	94	50615	13	5	7	1	16
SRP_00278	Archaea_SRP links to Rfam database...	0.81	0.73	0.89	77	45969	12	0	10	2	28
SRP_00321	Archaea_SRP links to Rfam database...	0.77	0.75	0.79	81	47483	24	3	19	2	27
SRP_00322	Archaea_SRP links to Rfam database...	0.71	0.66	0.76	72	48421	24	4	19	1	37
SRP_00323	Archaea_SRP links to Rfam database...	0.92	0.92	0.93	98	47173	11	0	7	4	9
SRP_00330	Archaea_SRP links to Rfam database...	0.50	0.44	0.57	42	50012	33	1	31	1	53
SRP_00332	Archaea_SRP links to Rfam database...	0.84	0.81	0.87	86	50304	16	6	7	3	20
SRP_00339	Archaea_SRP links to Rfam database...	0.67	0.64	0.70	60	44465	29	5	21	3	34

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1249
Total TN	2623051
Total FP	419
Total FP CONTRA	30
Total FP INCONS	360
Total FP COMP	29
Total FN	3354

Total Scores
MCC	0.454
Average MCC ± 95% Confidence Intervals	0.456 ± 0.042
Sensitivity	0.271
Positive Predictive Value	0.762
Nr of predictions	51

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Sfold - scored higher in this pairwise comparison

1. Total counts & total scores for Sfold

2. Individual counts for Sfold [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]