CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(20) - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(20) & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric TurboFold(20) Carnac(seed)
MCC 0.851 > 0.000
Average MCC ± 95% Confidence Intervals 0.854 ± 0.041 > 0.000 ± 0.000
Sensitivity 0.825 > 0.000
Positive Predictive Value 0.878 > 0.000
Total TP 1092 > 0
Total TN 736831 < 738075
Total FP 235 > 0
Total FP CONTRA 19 > 0
Total FP INCONS 133 > 0
Total FP COMP 83 > 0
Total FN 232 < 1324
P-value 1.67657656842e-08

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Performance plots


  1. Comparison of performance of TurboFold(20) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(20) and Carnac(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for TurboFold(20) and Carnac(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(20) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(20) and Carnac(seed)).

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Performance of TurboFold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 1092
Total TN 736831
Total FP 235
Total FP CONTRA 19
Total FP INCONS 133
Total FP COMP 83
Total FN 232
Total Scores
MCC 0.851
Average MCC ± 95% Confidence Intervals 0.854 ± 0.041
Sensitivity 0.825
Positive Predictive Value 0.878
Nr of predictions 13

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00599 0.74 0.74 0.74 82 101364 50 9 20 21 29
RFA_00601 0.76 0.75 0.77 85 99124 46 3 23 20 29
RFA_00602 0.85 0.84 0.85 98 101360 32 5 12 15 18
SRP_00011 0.81 0.79 0.83 82 46261 17 0 17 0 22
SRP_00015 0.91 0.87 0.95 86 46269 10 0 5 5 13
SRP_00152 0.93 0.90 0.96 93 45656 7 0 4 3 10
SRP_00178 0.91 0.87 0.96 89 45660 6 0 4 2 13
SRP_00179 0.92 0.88 0.97 92 45961 7 0 3 4 13
SRP_00181 0.85 0.81 0.89 83 45963 12 0 10 2 19
SRP_00182 0.88 0.84 0.92 85 45964 10 0 7 3 16
SRP_00184 0.85 0.80 0.90 80 45967 13 0 9 4 20
SRP_00188 0.93 0.90 0.96 71 31051 6 0 3 3 8
SRP_00308 0.77 0.75 0.79 66 36231 19 2 16 1 22

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 0
Total TN 738075
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 1324
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 13

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00599 0.00 0.00 0.00 0 101475 0 0 0 0 111
RFA_00601 0.00 0.00 0.00 0 99235 0 0 0 0 114
RFA_00602 0.00 0.00 0.00 0 101475 0 0 0 0 116
SRP_00011 0.00 0.00 0.00 0 46360 0 0 0 0 104
SRP_00015 0.00 0.00 0.00 0 46360 0 0 0 0 99
SRP_00152 0.00 0.00 0.00 0 45753 0 0 0 0 103
SRP_00178 0.00 0.00 0.00 0 45753 0 0 0 0 102
SRP_00179 0.00 0.00 0.00 0 46056 0 0 0 0 105
SRP_00181 0.00 0.00 0.00 0 46056 0 0 0 0 102
SRP_00182 0.00 0.00 0.00 0 46056 0 0 0 0 101
SRP_00184 0.00 0.00 0.00 0 46056 0 0 0 0 100
SRP_00188 0.00 0.00 0.00 0 31125 0 0 0 0 79
SRP_00308 0.00 0.00 0.00 0 36315 0 0 0 0 88

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.