CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	TurboFold(seed)		Afold
MCC	0.799	>	0.632
Average MCC ± 95% Confidence Intervals	0.821 ± 0.081	>	0.614 ± 0.134
Sensitivity	0.774	>	0.646
Positive Predictive Value	0.826	>	0.619
Total TP	724	>	605
Total TN	525624	>	525523
Total FP	277	<	507
Total FP CONTRA	29	<	99
Total FP INCONS	123	<	273
Total FP COMP	125	<	135
Total FN	212	<	331
P-value	2.24270395587e-08

Comparison of performance of TurboFold(seed) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and Afold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for TurboFold(seed) and Afold).
Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and Afold).

Total Scores
MCC	0.799
Average MCC ± 95% Confidence Intervals	0.821 ± 0.081
Sensitivity	0.774
Positive Predictive Value	0.826
Nr of predictions	13

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00210	RNaseP_arch links to Rfam database...	0.71	0.68	0.75	44	27202	16	4	11	1	21
RFA_00626	rne5 links to Rfam database...	0.90	0.85	0.95	74	56538	17	0	4	13	13
RFA_00627	rne5 links to Rfam database...	0.85	0.82	0.89	71	56873	23	0	9	14	16
RFA_00628	rne5 links to Rfam database...	0.92	0.90	0.95	77	57210	17	0	4	13	9
RFA_00630	rne5 links to Rfam database...	0.83	0.79	0.87	69	56874	22	0	10	12	18
RFA_00814	R2_retro_el links to Rfam database...	0.92	0.85	1.00	35	25165	13	0	0	13	6
RFA_00816	R2_retro_el links to Rfam database...	1.00	1.00	1.00	41	23179	14	0	0	14	0
RFA_00818	R2_retro_el links to Rfam database...	0.85	0.80	0.89	33	20264	11	1	3	7	8
RFA_00819	R2_retro_el links to Rfam database...	0.98	0.95	1.00	39	27927	27	0	0	27	2
SRP_00241	Plant_SRP links to Rfam database...	0.56	0.59	0.54	48	45967	43	12	29	2	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.78	0.72	0.85	78	50948	16	4	10	2	30
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.76	0.74	0.77	65	36231	20	2	17	1	23
SRP_00340	Metazoa_SRP links to Rfam database...	0.61	0.61	0.61	50	41246	38	6	26	6	32

Total Scores
MCC	0.632
Average MCC ± 95% Confidence Intervals	0.614 ± 0.134
Sensitivity	0.646
Positive Predictive Value	0.619
Nr of predictions	13

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00210	RNaseP_arch links to Rfam database...	0.61	0.62	0.60	40	27194	28	6	21	1	25
RFA_00626	rne5 links to Rfam database...	0.89	0.86	0.93	75	56535	31	2	4	25	12
RFA_00627	rne5 links to Rfam database...	0.48	0.47	0.48	41	56868	50	10	34	6	46
RFA_00628	rne5 links to Rfam database...	0.83	0.80	0.85	69	57210	38	1	11	26	17
RFA_00630	rne5 links to Rfam database...	0.60	0.60	0.60	52	56866	46	8	27	11	35
RFA_00814	R2_retro_el links to Rfam database...	0.35	0.37	0.33	15	25155	42	7	23	12	26
RFA_00816	R2_retro_el links to Rfam database...	0.59	0.66	0.53	27	23169	33	13	11	9	14
RFA_00818	R2_retro_el links to Rfam database...	0.19	0.22	0.17	9	20247	48	19	26	3	32
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	32	0	1	31	2
SRP_00241	Plant_SRP links to Rfam database...	0.54	0.59	0.51	48	45961	50	11	36	3	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.85	0.87	0.84	94	50928	20	4	14	2	14
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.55	0.55	0.56	48	36229	42	9	29	4	40
SRP_00340	Metazoa_SRP links to Rfam database...	0.55	0.59	0.52	48	41235	47	9	36	2	34

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.