CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	TurboFold(seed)		CRWrnafold
MCC	0.787	>	0.508
Average MCC ± 95% Confidence Intervals	0.805 ± 0.066	>	0.467 ± 0.118
Sensitivity	0.760	>	0.517
Positive Predictive Value	0.815	>	0.500
Total TP	1052	>	716
Total TN	797739	>	797599
Total FP	383	<	862
Total FP CONTRA	40	<	161
Total FP INCONS	199	<	554
Total FP COMP	144	<	147
Total FN	332	<	668
P-value	3.16042554876e-08

Comparison of performance of TurboFold(seed) and CRWrnafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and CRWrnafold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for TurboFold(seed) and CRWrnafold).
Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and CRWrnafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and CRWrnafold).

Total Scores
MCC	0.787
Average MCC ± 95% Confidence Intervals	0.805 ± 0.066
Sensitivity	0.760
Positive Predictive Value	0.815
Nr of predictions	18

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00210	RNaseP_arch links to Rfam database...	0.71	0.68	0.75	44	27202	16	4	11	1	21
RFA_00626	rne5 links to Rfam database...	0.90	0.85	0.95	74	56538	17	0	4	13	13
RFA_00627	rne5 links to Rfam database...	0.85	0.82	0.89	71	56873	23	0	9	14	16
RFA_00628	rne5 links to Rfam database...	0.92	0.90	0.95	77	57210	17	0	4	13	9
RFA_00630	rne5 links to Rfam database...	0.83	0.79	0.87	69	56874	22	0	10	12	18
RFA_00805	RNAIII links to Rfam database...	0.87	0.82	0.93	123	133254	13	0	9	4	27
RFA_00814	R2_retro_el links to Rfam database...	0.92	0.85	1.00	35	25165	13	0	0	13	6
RFA_00816	R2_retro_el links to Rfam database...	1.00	1.00	1.00	41	23179	14	0	0	14	0
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	7	0	0	7	4
RFA_00818	R2_retro_el links to Rfam database...	0.85	0.80	0.89	33	20264	11	1	3	7	8
RFA_00819	R2_retro_el links to Rfam database...	0.98	0.95	1.00	39	27927	27	0	0	27	2
SRP_00241	Plant_SRP links to Rfam database...	0.56	0.59	0.54	48	45967	43	12	29	2	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.78	0.72	0.85	78	50948	16	4	10	2	30
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.76	0.74	0.77	65	36231	20	2	17	1	23
SRP_00328	Metazoa_SRP links to Rfam database...	0.69	0.67	0.70	57	39540	27	5	19	3	28
SRP_00329	Metazoa_SRP links to Rfam database...	0.65	0.64	0.67	54	39822	30	3	24	3	31
SRP_00331	Metazoa_SRP links to Rfam database...	0.67	0.66	0.68	57	37591	29	3	24	2	30
SRP_00340	Metazoa_SRP links to Rfam database...	0.61	0.61	0.61	50	41246	38	6	26	6	32

Total Scores
MCC	0.508
Average MCC ± 95% Confidence Intervals	0.467 ± 0.118
Sensitivity	0.517
Positive Predictive Value	0.500
Nr of predictions	18

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00210	RNaseP_arch links to Rfam database...	0.48	0.48	0.49	31	27198	38	3	29	6	34
RFA_00626	rne5 links to Rfam database...	0.64	0.63	0.65	55	56532	42	8	21	13	32
RFA_00627	rne5 links to Rfam database...	0.65	0.63	0.67	55	56871	42	6	21	15	32
RFA_00628	rne5 links to Rfam database...	0.89	0.85	0.94	73	57213	30	0	5	25	13
RFA_00630	rne5 links to Rfam database...	0.57	0.57	0.57	50	56865	51	12	26	13	37
RFA_00805	RNAIII links to Rfam database...	0.48	0.48	0.49	72	133238	87	7	69	11	78
RFA_00814	R2_retro_el links to Rfam database...	0.24	0.27	0.21	11	25148	48	10	31	7	30
RFA_00816	R2_retro_el links to Rfam database...	0.21	0.24	0.19	10	23166	50	20	24	6	31
RFA_00817	R2_retro_el links to Rfam database...	0.10	0.12	0.08	5	21883	57	17	40	0	36
RFA_00818	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	20249	56	19	33	4	41
RFA_00819	R2_retro_el links to Rfam database...	0.44	0.44	0.44	18	27925	57	0	23	34	23
SRP_00241	Plant_SRP links to Rfam database...	0.54	0.57	0.51	47	45963	48	17	29	2	35
SRP_00257	Metazoa_SRP links to Rfam database...	0.81	0.79	0.83	85	50938	20	5	12	3	23
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.67	0.67	0.67	59	36227	29	4	25	0	29
SRP_00328	Metazoa_SRP links to Rfam database...	0.55	0.55	0.55	47	39536	41	8	30	3	38
SRP_00329	Metazoa_SRP links to Rfam database...	0.25	0.25	0.25	21	39818	65	10	54	1	64
SRP_00331	Metazoa_SRP links to Rfam database...	0.41	0.41	0.42	36	37589	51	7	43	1	51
SRP_00340	Metazoa_SRP links to Rfam database...	0.48	0.50	0.47	41	41240	50	8	39	3	41

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.