CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	TurboFold(seed)		CentroidHomfold‑LAST
MCC	0.776	>	0.747
Average MCC ± 95% Confidence Intervals	0.801 ± 0.070	>	0.751 ± 0.069
Sensitivity	0.753	>	0.652
Positive Predictive Value	0.802	<	0.858
Total TP	929	>	804
Total TN	664485	<	664707
Total FP	370	>	197
Total FP CONTRA	40	>	28
Total FP INCONS	190	>	105
Total FP COMP	140	>	64
Total FN	305	<	430
P-value	3.39090039918e-08

Comparison of performance of TurboFold(seed) and CentroidHomfold-LAST. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and CentroidHomfold‑LAST).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for TurboFold(seed) and CentroidHomfold‑LAST).
Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and CentroidHomfold-LAST. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and CentroidHomfold‑LAST).

Total Scores
MCC	0.776
Average MCC ± 95% Confidence Intervals	0.801 ± 0.070
Sensitivity	0.753
Positive Predictive Value	0.802
Nr of predictions	17

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00210	RNaseP_arch links to Rfam database...	0.71	0.68	0.75	44	27202	16	4	11	1	21
RFA_00626	rne5 links to Rfam database...	0.90	0.85	0.95	74	56538	17	0	4	13	13
RFA_00627	rne5 links to Rfam database...	0.85	0.82	0.89	71	56873	23	0	9	14	16
RFA_00628	rne5 links to Rfam database...	0.92	0.90	0.95	77	57210	17	0	4	13	9
RFA_00630	rne5 links to Rfam database...	0.83	0.79	0.87	69	56874	22	0	10	12	18
RFA_00814	R2_retro_el links to Rfam database...	0.92	0.85	1.00	35	25165	13	0	0	13	6
RFA_00816	R2_retro_el links to Rfam database...	1.00	1.00	1.00	41	23179	14	0	0	14	0
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	7	0	0	7	4
RFA_00818	R2_retro_el links to Rfam database...	0.85	0.80	0.89	33	20264	11	1	3	7	8
RFA_00819	R2_retro_el links to Rfam database...	0.98	0.95	1.00	39	27927	27	0	0	27	2
SRP_00241	Plant_SRP links to Rfam database...	0.56	0.59	0.54	48	45967	43	12	29	2	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.78	0.72	0.85	78	50948	16	4	10	2	30
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.76	0.74	0.77	65	36231	20	2	17	1	23
SRP_00328	Metazoa_SRP links to Rfam database...	0.69	0.67	0.70	57	39540	27	5	19	3	28
SRP_00329	Metazoa_SRP links to Rfam database...	0.65	0.64	0.67	54	39822	30	3	24	3	31
SRP_00331	Metazoa_SRP links to Rfam database...	0.67	0.66	0.68	57	37591	29	3	24	2	30
SRP_00340	Metazoa_SRP links to Rfam database...	0.61	0.61	0.61	50	41246	38	6	26	6	32

Total Scores
MCC	0.747
Average MCC ± 95% Confidence Intervals	0.751 ± 0.069
Sensitivity	0.652
Positive Predictive Value	0.858
Nr of predictions	17

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00210	RNaseP_arch links to Rfam database...	0.79	0.69	0.90	45	27211	5	0	5	0	20
RFA_00626	rne5 links to Rfam database...	0.85	0.79	0.92	69	56541	13	1	5	7	18
RFA_00627	rne5 links to Rfam database...	0.86	0.75	0.98	65	56887	13	0	1	12	22
RFA_00628	rne5 links to Rfam database...	0.86	0.78	0.94	67	57220	7	1	3	3	19
RFA_00630	rne5 links to Rfam database...	0.87	0.83	0.92	72	56875	10	1	5	4	15
RFA_00814	R2_retro_el links to Rfam database...	0.96	0.93	1.00	38	25162	6	0	0	6	3
RFA_00816	R2_retro_el links to Rfam database...	0.80	0.63	1.00	26	23194	1	0	0	1	15
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.59	0.80	24	21915	9	2	4	3	17
RFA_00818	R2_retro_el links to Rfam database...	0.57	0.54	0.61	22	20265	18	8	6	4	19
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.93	0.97	38	27927	15	0	1	14	3
SRP_00241	Plant_SRP links to Rfam database...	0.65	0.51	0.82	42	46005	10	0	9	1	40
SRP_00257	Metazoa_SRP links to Rfam database...	0.83	0.74	0.93	80	50954	8	3	3	2	28
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.56	0.34	0.91	30	36282	3	0	3	0	58
SRP_00328	Metazoa_SRP links to Rfam database...	0.67	0.66	0.69	56	39540	29	7	18	4	29
SRP_00329	Metazoa_SRP links to Rfam database...	0.64	0.61	0.68	52	39826	28	4	21	3	33
SRP_00331	Metazoa_SRP links to Rfam database...	0.60	0.53	0.69	46	37608	21	1	20	0	41
SRP_00340	Metazoa_SRP links to Rfam database...	0.61	0.39	0.97	32	41295	1	0	1	0	50

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.