CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	TurboFold(seed)		RNASLOpt
MCC	0.776	>	0.463
Average MCC ± 95% Confidence Intervals	0.801 ± 0.070	>	0.454 ± 0.113
Sensitivity	0.753	>	0.454
Positive Predictive Value	0.802	>	0.473
Total TP	929	>	560
Total TN	664485	>	664461
Total FP	370	<	701
Total FP CONTRA	40	<	140
Total FP INCONS	190	<	483
Total FP COMP	140	>	78
Total FN	305	<	674
P-value	2.78993384543e-08

Comparison of performance of TurboFold(seed) and RNASLOpt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and RNASLOpt).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for TurboFold(seed) and RNASLOpt).
Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and RNASLOpt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and RNASLOpt).

Total Scores
MCC	0.776
Average MCC ± 95% Confidence Intervals	0.801 ± 0.070
Sensitivity	0.753
Positive Predictive Value	0.802
Nr of predictions	17

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00210	RNaseP_arch links to Rfam database...	0.71	0.68	0.75	44	27202	16	4	11	1	21
RFA_00626	rne5 links to Rfam database...	0.90	0.85	0.95	74	56538	17	0	4	13	13
RFA_00627	rne5 links to Rfam database...	0.85	0.82	0.89	71	56873	23	0	9	14	16
RFA_00628	rne5 links to Rfam database...	0.92	0.90	0.95	77	57210	17	0	4	13	9
RFA_00630	rne5 links to Rfam database...	0.83	0.79	0.87	69	56874	22	0	10	12	18
RFA_00814	R2_retro_el links to Rfam database...	0.92	0.85	1.00	35	25165	13	0	0	13	6
RFA_00816	R2_retro_el links to Rfam database...	1.00	1.00	1.00	41	23179	14	0	0	14	0
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	7	0	0	7	4
RFA_00818	R2_retro_el links to Rfam database...	0.85	0.80	0.89	33	20264	11	1	3	7	8
RFA_00819	R2_retro_el links to Rfam database...	0.98	0.95	1.00	39	27927	27	0	0	27	2
SRP_00241	Plant_SRP links to Rfam database...	0.56	0.59	0.54	48	45967	43	12	29	2	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.78	0.72	0.85	78	50948	16	4	10	2	30
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.76	0.74	0.77	65	36231	20	2	17	1	23
SRP_00328	Metazoa_SRP links to Rfam database...	0.69	0.67	0.70	57	39540	27	5	19	3	28
SRP_00329	Metazoa_SRP links to Rfam database...	0.65	0.64	0.67	54	39822	30	3	24	3	31
SRP_00331	Metazoa_SRP links to Rfam database...	0.67	0.66	0.68	57	37591	29	3	24	2	30
SRP_00340	Metazoa_SRP links to Rfam database...	0.61	0.61	0.61	50	41246	38	6	26	6	32

Total Scores
MCC	0.463
Average MCC ± 95% Confidence Intervals	0.454 ± 0.113
Sensitivity	0.454
Positive Predictive Value	0.473
Nr of predictions	17

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00210	RNaseP_arch links to Rfam database...	0.36	0.34	0.38	22	27203	38	4	32	2	43
RFA_00626	rne5 links to Rfam database...	0.68	0.64	0.72	56	56538	30	6	16	8	31
RFA_00627	rne5 links to Rfam database...	0.61	0.60	0.62	52	56869	41	11	21	9	35
RFA_00628	rne5 links to Rfam database...	0.89	0.84	0.95	72	57215	15	0	4	11	14
RFA_00630	rne5 links to Rfam database...	0.69	0.67	0.72	58	56872	32	5	18	9	29
RFA_00814	R2_retro_el links to Rfam database...	0.51	0.51	0.51	21	25159	29	9	11	9	20
RFA_00816	R2_retro_el links to Rfam database...	0.58	0.63	0.53	26	23171	26	13	10	3	15
RFA_00817	R2_retro_el links to Rfam database...	0.24	0.27	0.22	11	21896	42	12	26	4	30
RFA_00818	R2_retro_el links to Rfam database...	0.21	0.22	0.21	9	20258	39	14	20	5	32
RFA_00819	R2_retro_el links to Rfam database...	0.60	0.68	0.53	28	27913	34	16	9	9	13
SRP_00241	Plant_SRP links to Rfam database...	0.26	0.27	0.26	22	45970	66	14	50	2	60
SRP_00257	Metazoa_SRP links to Rfam database...	0.56	0.52	0.61	56	50948	37	1	35	1	52
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.14	0.14	0.15	12	36233	70	11	59	0	76
SRP_00328	Metazoa_SRP links to Rfam database...	0.60	0.60	0.61	51	39537	36	7	26	3	34
SRP_00329	Metazoa_SRP links to Rfam database...	0.34	0.32	0.36	27	39829	50	4	43	3	58
SRP_00331	Metazoa_SRP links to Rfam database...	0.15	0.13	0.17	11	37612	52	1	51	0	76
SRP_00340	Metazoa_SRP links to Rfam database...	0.30	0.32	0.29	26	41238	64	12	52	0	56

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.