CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	TurboFold(seed)		RNAshapes
MCC	0.772	>	0.593
Average MCC ± 95% Confidence Intervals	0.799 ± 0.075	>	0.574 ± 0.108
Sensitivity	0.750	>	0.603
Positive Predictive Value	0.796	>	0.585
Total TP	860	>	692
Total TN	607611	>	607508
Total FP	348	<	609
Total FP CONTRA	40	<	113
Total FP INCONS	180	<	378
Total FP COMP	128	>	118
Total FN	287	<	455
P-value	1.58287649515e-08

Comparison of performance of TurboFold(seed) and RNAshapes. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and RNAshapes).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for TurboFold(seed) and RNAshapes).
Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and RNAshapes. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and RNAshapes).

Total Scores
MCC	0.772
Average MCC ± 95% Confidence Intervals	0.799 ± 0.075
Sensitivity	0.750
Positive Predictive Value	0.796
Nr of predictions	16

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00210	RNaseP_arch links to Rfam database...	0.71	0.68	0.75	44	27202	16	4	11	1	21
RFA_00626	rne5 links to Rfam database...	0.90	0.85	0.95	74	56538	17	0	4	13	13
RFA_00627	rne5 links to Rfam database...	0.85	0.82	0.89	71	56873	23	0	9	14	16
RFA_00628	rne5 links to Rfam database...	0.92	0.90	0.95	77	57210	17	0	4	13	9
RFA_00814	R2_retro_el links to Rfam database...	0.92	0.85	1.00	35	25165	13	0	0	13	6
RFA_00816	R2_retro_el links to Rfam database...	1.00	1.00	1.00	41	23179	14	0	0	14	0
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	7	0	0	7	4
RFA_00818	R2_retro_el links to Rfam database...	0.85	0.80	0.89	33	20264	11	1	3	7	8
RFA_00819	R2_retro_el links to Rfam database...	0.98	0.95	1.00	39	27927	27	0	0	27	2
SRP_00241	Plant_SRP links to Rfam database...	0.56	0.59	0.54	48	45967	43	12	29	2	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.78	0.72	0.85	78	50948	16	4	10	2	30
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.76	0.74	0.77	65	36231	20	2	17	1	23
SRP_00328	Metazoa_SRP links to Rfam database...	0.69	0.67	0.70	57	39540	27	5	19	3	28
SRP_00329	Metazoa_SRP links to Rfam database...	0.65	0.64	0.67	54	39822	30	3	24	3	31
SRP_00331	Metazoa_SRP links to Rfam database...	0.67	0.66	0.68	57	37591	29	3	24	2	30
SRP_00340	Metazoa_SRP links to Rfam database...	0.61	0.61	0.61	50	41246	38	6	26	6	32

Total Scores
MCC	0.593
Average MCC ± 95% Confidence Intervals	0.574 ± 0.108
Sensitivity	0.603
Positive Predictive Value	0.585
Nr of predictions	16

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00210	RNaseP_arch links to Rfam database...	0.55	0.55	0.55	36	27196	29	5	24	0	29
RFA_00626	rne5 links to Rfam database...	0.45	0.45	0.46	39	56531	61	9	37	15	48
RFA_00627	rne5 links to Rfam database...	0.63	0.61	0.66	53	56873	42	4	23	15	34
RFA_00628	rne5 links to Rfam database...	0.82	0.80	0.84	69	57209	33	1	12	20	17
RFA_00814	R2_retro_el links to Rfam database...	0.62	0.63	0.60	26	25157	26	6	11	9	15
RFA_00816	R2_retro_el links to Rfam database...	0.21	0.24	0.18	10	23164	47	18	28	1	31
RFA_00817	R2_retro_el links to Rfam database...	0.10	0.12	0.08	5	21881	60	21	38	1	36
RFA_00818	R2_retro_el links to Rfam database...	0.52	0.56	0.48	23	20253	31	9	16	6	18
RFA_00819	R2_retro_el links to Rfam database...	0.84	0.80	0.87	33	27928	36	0	5	31	8
SRP_00241	Plant_SRP links to Rfam database...	0.55	0.59	0.52	48	45963	47	13	32	2	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.86	0.83	0.88	90	50938	17	1	11	5	18
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.57	0.56	0.58	49	36231	37	3	32	2	39
SRP_00328	Metazoa_SRP links to Rfam database...	0.64	0.65	0.63	55	39533	38	8	25	5	30
SRP_00329	Metazoa_SRP links to Rfam database...	0.67	0.66	0.67	56	39820	28	4	23	1	29
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.61	0.66	53	37595	30	2	25	3	34
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.57	0.51	47	41236	47	9	36	2	35

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.