CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	TurboFold(seed)		RNAsubopt
MCC	0.776	>	0.590
Average MCC ± 95% Confidence Intervals	0.801 ± 0.070	>	0.588 ± 0.110
Sensitivity	0.753	>	0.604
Positive Predictive Value	0.802	>	0.578
Total TP	929	>	745
Total TN	664485	>	664354
Total FP	370	<	699
Total FP CONTRA	40	<	125
Total FP INCONS	190	<	420
Total FP COMP	140	<	154
Total FN	305	<	489
P-value	2.41358941668e-08

Comparison of performance of TurboFold(seed) and RNAsubopt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and RNAsubopt).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for TurboFold(seed) and RNAsubopt).
Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and RNAsubopt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and RNAsubopt).

Total Scores
MCC	0.776
Average MCC ± 95% Confidence Intervals	0.801 ± 0.070
Sensitivity	0.753
Positive Predictive Value	0.802
Nr of predictions	17

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00210	RNaseP_arch links to Rfam database...	0.71	0.68	0.75	44	27202	16	4	11	1	21
RFA_00626	rne5 links to Rfam database...	0.90	0.85	0.95	74	56538	17	0	4	13	13
RFA_00627	rne5 links to Rfam database...	0.85	0.82	0.89	71	56873	23	0	9	14	16
RFA_00628	rne5 links to Rfam database...	0.92	0.90	0.95	77	57210	17	0	4	13	9
RFA_00630	rne5 links to Rfam database...	0.83	0.79	0.87	69	56874	22	0	10	12	18
RFA_00814	R2_retro_el links to Rfam database...	0.92	0.85	1.00	35	25165	13	0	0	13	6
RFA_00816	R2_retro_el links to Rfam database...	1.00	1.00	1.00	41	23179	14	0	0	14	0
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	7	0	0	7	4
RFA_00818	R2_retro_el links to Rfam database...	0.85	0.80	0.89	33	20264	11	1	3	7	8
RFA_00819	R2_retro_el links to Rfam database...	0.98	0.95	1.00	39	27927	27	0	0	27	2
SRP_00241	Plant_SRP links to Rfam database...	0.56	0.59	0.54	48	45967	43	12	29	2	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.78	0.72	0.85	78	50948	16	4	10	2	30
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.76	0.74	0.77	65	36231	20	2	17	1	23
SRP_00328	Metazoa_SRP links to Rfam database...	0.69	0.67	0.70	57	39540	27	5	19	3	28
SRP_00329	Metazoa_SRP links to Rfam database...	0.65	0.64	0.67	54	39822	30	3	24	3	31
SRP_00331	Metazoa_SRP links to Rfam database...	0.67	0.66	0.68	57	37591	29	3	24	2	30
SRP_00340	Metazoa_SRP links to Rfam database...	0.61	0.61	0.61	50	41246	38	6	26	6	32

Total Scores
MCC	0.590
Average MCC ± 95% Confidence Intervals	0.588 ± 0.110
Sensitivity	0.604
Positive Predictive Value	0.578
Nr of predictions	17

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00210	RNaseP_arch links to Rfam database...	0.47	0.48	0.47	31	27195	36	7	28	1	34
RFA_00626	rne5 links to Rfam database...	0.68	0.66	0.70	57	56535	42	6	18	18	30
RFA_00627	rne5 links to Rfam database...	0.72	0.68	0.77	59	56876	33	4	14	15	28
RFA_00628	rne5 links to Rfam database...	0.89	0.86	0.91	74	57210	32	2	5	25	12
RFA_00630	rne5 links to Rfam database...	0.58	0.60	0.57	52	56861	51	12	28	11	35
RFA_00814	R2_retro_el links to Rfam database...	0.39	0.39	0.39	16	25159	40	5	20	15	25
RFA_00816	R2_retro_el links to Rfam database...	0.74	0.78	0.70	32	23174	24	8	6	10	9
RFA_00817	R2_retro_el links to Rfam database...	0.35	0.41	0.30	17	21889	43	11	28	4	24
RFA_00818	R2_retro_el links to Rfam database...	0.47	0.54	0.41	22	20247	39	13	19	7	19
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	31	0	1	30	2
SRP_00241	Plant_SRP links to Rfam database...	0.55	0.59	0.52	48	45963	48	12	33	3	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.80	0.81	0.79	87	50930	26	4	19	3	21
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.06	0.07	0.06	6	36221	88	12	76	0	82
SRP_00328	Metazoa_SRP links to Rfam database...	0.64	0.66	0.63	56	39532	38	8	25	5	29
SRP_00329	Metazoa_SRP links to Rfam database...	0.61	0.62	0.60	53	39814	37	10	26	1	32
SRP_00331	Metazoa_SRP links to Rfam database...	0.55	0.55	0.55	48	37587	43	3	37	3	39
SRP_00340	Metazoa_SRP links to Rfam database...	0.55	0.59	0.52	48	41235	48	8	37	3	34

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.