CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	TurboFold(seed)		RNAwolf
MCC	0.787	>	0.369
Average MCC ± 95% Confidence Intervals	0.805 ± 0.066	>	0.340 ± 0.105
Sensitivity	0.760	>	0.385
Positive Predictive Value	0.815	>	0.355
Total TP	1052	>	533
Total TN	797739	>	797528
Total FP	383	<	1207
Total FP CONTRA	40	<	196
Total FP INCONS	199	<	773
Total FP COMP	144	<	238
Total FN	332	<	851
P-value	2.9966815982e-08

Comparison of performance of TurboFold(seed) and RNAwolf. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and RNAwolf).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for TurboFold(seed) and RNAwolf).
Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and RNAwolf. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and RNAwolf).

Total Scores
MCC	0.787
Average MCC ± 95% Confidence Intervals	0.805 ± 0.066
Sensitivity	0.760
Positive Predictive Value	0.815
Nr of predictions	18

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00210	RNaseP_arch links to Rfam database...	0.71	0.68	0.75	44	27202	16	4	11	1	21
RFA_00626	rne5 links to Rfam database...	0.90	0.85	0.95	74	56538	17	0	4	13	13
RFA_00627	rne5 links to Rfam database...	0.85	0.82	0.89	71	56873	23	0	9	14	16
RFA_00628	rne5 links to Rfam database...	0.92	0.90	0.95	77	57210	17	0	4	13	9
RFA_00630	rne5 links to Rfam database...	0.83	0.79	0.87	69	56874	22	0	10	12	18
RFA_00805	RNAIII links to Rfam database...	0.87	0.82	0.93	123	133254	13	0	9	4	27
RFA_00814	R2_retro_el links to Rfam database...	0.92	0.85	1.00	35	25165	13	0	0	13	6
RFA_00816	R2_retro_el links to Rfam database...	1.00	1.00	1.00	41	23179	14	0	0	14	0
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	7	0	0	7	4
RFA_00818	R2_retro_el links to Rfam database...	0.85	0.80	0.89	33	20264	11	1	3	7	8
RFA_00819	R2_retro_el links to Rfam database...	0.98	0.95	1.00	39	27927	27	0	0	27	2
SRP_00241	Plant_SRP links to Rfam database...	0.56	0.59	0.54	48	45967	43	12	29	2	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.78	0.72	0.85	78	50948	16	4	10	2	30
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.76	0.74	0.77	65	36231	20	2	17	1	23
SRP_00328	Metazoa_SRP links to Rfam database...	0.69	0.67	0.70	57	39540	27	5	19	3	28
SRP_00329	Metazoa_SRP links to Rfam database...	0.65	0.64	0.67	54	39822	30	3	24	3	31
SRP_00331	Metazoa_SRP links to Rfam database...	0.67	0.66	0.68	57	37591	29	3	24	2	30
SRP_00340	Metazoa_SRP links to Rfam database...	0.61	0.61	0.61	50	41246	38	6	26	6	32

Total Scores
MCC	0.369
Average MCC ± 95% Confidence Intervals	0.340 ± 0.105
Sensitivity	0.385
Positive Predictive Value	0.355
Nr of predictions	18

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00210	RNaseP_arch links to Rfam database...	0.62	0.63	0.61	41	27194	39	9	17	13	24
RFA_00626	rne5 links to Rfam database...	0.08	0.09	0.08	8	56511	99	24	73	2	79
RFA_00627	rne5 links to Rfam database...	0.38	0.39	0.37	34	56862	73	13	44	16	53
RFA_00628	rne5 links to Rfam database...	0.58	0.57	0.59	49	57208	64	7	27	30	37
RFA_00630	rne5 links to Rfam database...	0.48	0.47	0.49	41	56869	66	9	34	23	46
RFA_00805	RNAIII links to Rfam database...	0.30	0.31	0.29	47	133225	121	13	101	7	103
RFA_00814	R2_retro_el links to Rfam database...	0.20	0.22	0.18	9	25149	62	12	30	20	32
RFA_00816	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	23162	66	17	41	8	41
RFA_00817	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	21892	57	12	41	4	41
RFA_00818	R2_retro_el links to Rfam database...	0.25	0.27	0.23	11	20253	51	12	25	14	30
RFA_00819	R2_retro_el links to Rfam database...	0.16	0.17	0.16	7	27921	70	6	32	32	34
SRP_00241	Plant_SRP links to Rfam database...	0.55	0.60	0.51	49	45959	61	14	34	13	33
SRP_00257	Metazoa_SRP links to Rfam database...	0.68	0.69	0.67	75	50928	49	5	32	12	33
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.27	0.26	0.27	23	36231	62	13	48	1	65
SRP_00328	Metazoa_SRP links to Rfam database...	0.32	0.33	0.31	28	39530	68	12	51	5	57
SRP_00329	Metazoa_SRP links to Rfam database...	0.31	0.33	0.30	28	39810	75	5	60	10	57
SRP_00331	Metazoa_SRP links to Rfam database...	0.61	0.61	0.61	53	37588	49	3	31	15	34
SRP_00340	Metazoa_SRP links to Rfam database...	0.34	0.37	0.33	30	41236	75	10	52	13	52

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.