CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Afold - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Afold & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric Afold Carnac(seed)
MCC 0.779 > 0.729
Average MCC ± 95% Confidence Intervals 0.779 ± > 0.729 ±
Sensitivity 0.766 > 0.570
Positive Predictive Value 0.792 < 0.932
Total TP 351 > 261
Total TN 1085158 < 1085321
Total FP 132 > 35
Total FP CONTRA 17 > 6
Total FP INCONS 75 > 13
Total FP COMP 40 > 16
Total FN 107 < 197
P-value 0.0

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Performance plots


  1. Comparison of performance of Afold and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and Carnac(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and Carnac(seed)).

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Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 351
Total TN 1085158
Total FP 132
Total FP CONTRA 17
Total FP INCONS 75
Total FP COMP 40
Total FN 107
Total Scores
MCC 0.779
Average MCC ± 95% Confidence Intervals 0.779 ±
Sensitivity 0.766
Positive Predictive Value 0.792
Nr of predictions 1

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00024 0.78 0.77 0.79 351 1085158 132 17 75 40 107

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 261
Total TN 1085321
Total FP 35
Total FP CONTRA 6
Total FP INCONS 13
Total FP COMP 16
Total FN 197
Total Scores
MCC 0.729
Average MCC ± 95% Confidence Intervals 0.729 ±
Sensitivity 0.570
Positive Predictive Value 0.932
Nr of predictions 1

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00024 0.73 0.57 0.93 261 1085321 35 6 13 16 197

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.