CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	CentroidAlifold(20)		CentroidFold
MCC	0.729	>	0.492
Average MCC ± 95% Confidence Intervals	0.721 ± 0.036	>	0.493 ± 0.028
Sensitivity	0.618	>	0.430
Positive Predictive Value	0.861	>	0.563
Total TP	22503	>	15655
Total TN	102217377	>	102215715
Total FP	5451	<	14303
Total FP CONTRA	624	<	1836
Total FP INCONS	3009	<	10307
Total FP COMP	1818	<	2160
Total FN	13927	<	20775
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of CentroidAlifold(20) and CentroidFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(20) and CentroidFold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidAlifold(20) and CentroidFold).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(20) and CentroidFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(20) and CentroidFold).

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Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

Total Base Pair Counts
Total TP	22503
Total TN	102217377
Total FP	5451
Total FP CONTRA	624
Total FP INCONS	3009
Total FP COMP	1818
Total FN	13927

Total Scores
MCC	0.729
Average MCC ± 95% Confidence Intervals	0.721 ± 0.036
Sensitivity	0.618
Positive Predictive Value	0.861
Nr of predictions	76

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2. Individual counts for CentroidAlifold(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.91	0.86	0.95	394	1085188	51	6	13	32	64
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.83	0.77	0.90	365	1141911	54	9	31	14	109
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	374	1170812	45	10	19	16	96
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	364	1107423	43	10	19	14	92
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.85	0.78	0.93	368	1172351	42	9	18	15	105
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.92	380	1181542	47	10	21	16	96
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.91	365	1108906	48	11	23	14	92
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.86	0.78	0.95	363	1178497	43	4	16	23	102
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.92	372	1135875	46	11	20	15	91
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.85	0.78	0.93	371	1201625	47	10	19	18	105
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.92	372	1152515	48	10	24	14	94
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.84	0.77	0.91	364	1180015	52	13	24	15	107
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.86	0.78	0.94	364	1190809	45	4	19	22	104
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.80	0.75	0.86	332	1082272	67	11	41	15	113
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.83	0.75	0.92	356	1178493	48	7	24	17	117
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.86	0.79	0.94	377	1207832	45	8	18	19	98
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.86	0.79	0.94	378	1198524	39	8	16	15	100
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	367	1105932	46	9	20	17	86
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.85	0.77	0.92	375	1218735	46	11	20	15	109
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.84	0.77	0.92	370	1198524	46	11	21	14	108
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.84	0.77	0.91	360	1192345	51	10	25	16	108
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.92	362	1111893	46	11	20	15	93
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.84	0.77	0.91	355	1122363	48	8	25	15	107
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.86	0.79	0.92	354	1085218	46	8	21	17	92
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	371	1114870	46	9	21	16	86
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.85	0.78	0.91	354	1110408	50	12	21	17	99
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.84	0.78	0.91	351	1129869	54	7	29	18	99
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.84	0.77	0.92	357	1180030	50	8	21	21	107
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.89	357	1117860	63	9	34	20	96
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.84	0.77	0.92	357	1144951	49	9	24	16	107
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.84	0.77	0.91	350	1131377	50	7	26	17	106
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.83	0.77	0.90	353	1117869	56	11	27	18	105
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.82	0.75	0.91	356	1189260	53	9	28	16	120
CRW_00298	SSU_rRNA_eukarya links to Rfam database...	0.52	0.37	0.72	183	1620647	90	6	64	20	311
CRW_00301	SSU_rRNA_eukarya links to Rfam database...	0.47	0.34	0.64	178	1762223	133	11	91	31	341
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.52	0.37	0.73	171	1445616	97	6	57	34	291
CRW_00310	SSU_rRNA_eukarya links to Rfam database...	0.49	0.37	0.66	192	1805657	126	13	88	25	329
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.57	0.40	0.80	201	1627859	78	6	44	28	301
CRW_00330	SSU_rRNA_eukarya links to Rfam database...	0.51	0.37	0.71	190	1988747	113	10	68	35	327
CRW_00332	SSU_rRNA_eukarya links to Rfam database...	0.48	0.34	0.67	161	1769781	123	8	71	44	316
CRW_00333	SSU_rRNA_eukarya links to Rfam database...	0.43	0.30	0.61	155	1892229	131	20	81	30	359
CRW_00345	SSU_rRNA_eukarya links to Rfam database...	0.51	0.36	0.72	181	1586621	96	8	61	27	317
CRW_00346	SSU_rRNA_eukarya links to Rfam database...	0.53	0.38	0.74	192	1584829	102	6	63	33	309
CRW_00348	SSU_rRNA_eukarya links to Rfam database...	0.54	0.40	0.72	200	1615226	107	10	67	30	303
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.53	0.39	0.73	196	1675098	99	8	63	28	311
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.52	0.37	0.71	180	1579501	100	8	64	28	302
CRW_00370	SSU_rRNA_eukarya links to Rfam database...	0.58	0.41	0.83	208	1640515	64	4	39	21	298
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.55	0.40	0.75	199	1611646	93	8	57	28	297
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.50	0.37	0.69	182	1626042	112	11	71	30	316
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.51	0.35	0.73	182	1751006	96	7	61	28	333
CRW_00403	SSU_rRNA_eukarya links to Rfam database...	0.52	0.39	0.70	180	1606270	126	11	67	48	284
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.51	0.38	0.68	189	1615224	117	8	82	27	307
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.48	0.34	0.67	170	1665972	109	11	72	26	325
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.86	0.79	0.93	364	1116372	45	9	20	16	94
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.86	0.78	0.94	347	1094091	45	2	20	23	98
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.86	0.79	0.93	359	1119369	53	3	25	25	93
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.86	0.79	0.92	354	1098520	55	6	23	26	92
CRW_00598	SSU_rRNA_eukarya links to Rfam database...	0.49	0.34	0.70	169	1665982	103	5	69	29	322
CRW_00758	SSU_rRNA_eukarya links to Rfam database...	0.52	0.38	0.72	184	1640510	108	6	66	36	299
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.51	0.38	0.69	181	1636884	113	8	72	33	300
CRW_00760	SSU_rRNA_eukarya links to Rfam database...	0.52	0.37	0.74	180	1638713	102	7	55	40	306
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.79	0.73	0.85	295	945652	81	5	48	28	109
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.83	0.76	0.91	340	1137411	63	5	30	28	107
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.80	0.72	0.88	284	1152598	97	3	36	58	110
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	357	1117854	65	10	39	16	113
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.91	369	1135873	50	13	23	14	95
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.50	0.36	0.69	179	1606270	108	8	71	29	324
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.49	0.36	0.67	183	1593733	116	11	78	27	323
CRW_01300	SSU_rRNA_eukarya links to Rfam database...	0.55	0.40	0.76	205	1693451	88	6	58	24	310
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.81	0.70	0.92	348	1073468	55	8	21	26	147
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.77	0.65	0.90	348	1500393	73	4	33	36	187
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.75	0.62	0.90	341	1471090	76	2	37	37	206
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.77	0.64	0.92	361	1606134	59	8	25	26	201
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.78	0.66	0.92	359	1433581	59	2	29	28	181
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.79	0.68	0.92	357	1204739	53	7	25	21	170
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.80	0.69	0.91	341	1117886	62	6	27	29	150

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Performance of CentroidFold - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidFold

Total Base Pair Counts
Total TP	15655
Total TN	102215715
Total FP	14303
Total FP CONTRA	1836
Total FP INCONS	10307
Total FP COMP	2160
Total FN	20775

Total Scores
MCC	0.492
Average MCC ± 95% Confidence Intervals	0.493 ± 0.028
Sensitivity	0.430
Positive Predictive Value	0.563
Nr of predictions	76

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2. Individual counts for CentroidFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.79	0.76	0.83	347	1085183	108	8	63	37	111
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.68	0.66	0.71	312	1141875	159	19	110	30	162
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.60	0.49	0.75	230	1170907	91	8	70	13	240
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.56	0.49	0.64	223	1107466	140	16	111	13	233
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.60	0.51	0.71	241	1172408	111	9	88	14	232
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.64	0.57	0.72	269	1181581	110	23	80	7	207
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.55	0.49	0.63	225	1108945	147	19	116	12	232
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.56	0.49	0.63	228	1178519	155	15	118	22	237
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.59	0.49	0.70	226	1135957	106	11	84	11	237
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.63	0.56	0.70	268	1201642	136	16	99	21	208
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.55	0.47	0.66	217	1152591	126	17	96	13	249
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.51	0.42	0.62	200	1180095	129	14	107	8	271
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.61	0.53	0.70	247	1190845	120	6	98	16	221
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.35	0.31	0.39	139	1082299	226	23	195	8	306
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.52	0.45	0.59	213	1178522	162	17	128	17	260
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.59	0.52	0.67	247	1207869	131	18	101	12	228
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.59	0.52	0.67	250	1198552	140	19	105	16	228
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.56	0.49	0.65	221	1105989	128	13	105	10	232
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.66	0.61	0.71	296	1218724	154	20	101	33	188
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.57	0.50	0.66	237	1198568	130	20	101	9	241
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.45	0.35	0.57	165	1192449	145	20	106	19	303
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.67	0.57	0.79	260	1111955	83	11	60	12	195
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.48	0.41	0.55	190	1122405	171	26	130	15	272
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.51	0.43	0.60	194	1085280	142	14	113	15	252
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.70	249	1114913	130	13	96	21	208
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.48	0.36	0.64	165	1110536	105	15	79	11	288
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.49	0.41	0.57	186	1129931	157	13	126	18	264
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.54	0.45	0.64	209	1180088	132	19	100	13	255
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.53	0.42	0.67	192	1117973	105	9	86	10	261
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.62	0.57	0.68	265	1144950	146	18	108	20	199
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.48	0.36	0.65	162	1131511	101	11	76	14	294
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.67	0.59	0.76	268	1117909	98	16	67	15	190
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.61	0.55	0.68	260	1189270	143	18	105	20	216
CRW_00298	SSU_rRNA_eukarya links to Rfam database...	0.25	0.22	0.28	109	1620517	295	50	224	21	385
CRW_00301	SSU_rRNA_eukarya links to Rfam database...	0.48	0.39	0.58	203	1762152	211	28	120	63	316
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.29	0.26	0.32	120	1445480	309	50	200	59	342
CRW_00310	SSU_rRNA_eukarya links to Rfam database...	0.38	0.34	0.42	178	1805524	303	44	204	55	343
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.57	0.48	0.67	240	1627752	163	19	99	45	262
CRW_00330	SSU_rRNA_eukarya links to Rfam database...	0.30	0.25	0.36	131	1988654	302	33	197	72	386
CRW_00332	SSU_rRNA_eukarya links to Rfam database...	0.25	0.22	0.28	104	1769656	299	47	214	38	373
CRW_00333	SSU_rRNA_eukarya links to Rfam database...	0.30	0.24	0.36	125	1892139	288	29	192	67	389
CRW_00345	SSU_rRNA_eukarya links to Rfam database...	0.41	0.37	0.45	186	1586456	267	40	189	38	312
CRW_00346	SSU_rRNA_eukarya links to Rfam database...	0.40	0.38	0.42	189	1584645	289	48	208	33	312
CRW_00348	SSU_rRNA_eukarya links to Rfam database...	0.37	0.31	0.44	157	1615148	235	27	171	37	346
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.42	0.39	0.45	200	1674917	285	39	209	37	307
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.34	0.31	0.38	150	1579355	289	44	204	41	332
CRW_00370	SSU_rRNA_eukarya links to Rfam database...	0.38	0.33	0.43	167	1640375	256	43	181	32	339
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.47	0.39	0.56	194	1611562	196	29	125	42	302
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.48	0.41	0.58	202	1625955	204	26	123	55	296
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.32	0.30	0.34	156	1750800	337	47	253	37	359
CRW_00403	SSU_rRNA_eukarya links to Rfam database...	0.31	0.29	0.34	135	1606132	324	52	209	63	329
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.42	0.35	0.49	173	1615153	226	27	150	49	323
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.42	0.36	0.48	180	1665851	239	34	160	45	315
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.71	0.64	0.79	292	1116394	100	14	65	21	166
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.34	0.28	0.42	125	1094162	188	16	157	15	320
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.37	0.32	0.43	143	1119420	207	36	157	14	309
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.65	0.59	0.72	261	1098541	124	19	82	23	185
CRW_00598	SSU_rRNA_eukarya links to Rfam database...	0.40	0.37	0.45	180	1665823	270	42	180	48	311
CRW_00758	SSU_rRNA_eukarya links to Rfam database...	0.37	0.34	0.40	164	1640353	298	41	208	49	319
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.34	0.28	0.42	134	1636828	232	34	149	49	347
CRW_00760	SSU_rRNA_eukarya links to Rfam database...	0.38	0.34	0.42	167	1638559	278	50	179	49	319
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.38	0.30	0.50	120	945758	137	16	106	15	284
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.51	0.40	0.65	179	1137510	120	5	92	23	268
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.35	0.28	0.44	110	1152672	173	15	124	34	284
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.59	0.56	0.62	265	1117830	190	14	151	25	205
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	256	1135921	119	15	86	18	208
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.41	0.37	0.45	185	1606114	268	39	190	39	318
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.46	0.41	0.52	206	1593608	228	40	151	37	300
CRW_01300	SSU_rRNA_eukarya links to Rfam database...	0.41	0.37	0.45	192	1693289	291	56	183	52	323
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.55	0.49	0.61	244	1073448	180	13	140	27	251
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.53	0.49	0.57	264	1500316	234	15	183	36	271
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.46	0.39	0.55	215	1471076	203	25	154	24	332
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.57	0.53	0.61	297	1606045	214	20	166	28	265
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.62	0.57	0.68	307	1433517	177	8	139	30	233
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.49	0.42	0.59	220	1204752	177	19	137	21	307
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.51	0.47	0.56	229	1117849	211	14	168	29	262

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

2. Individual counts for CentroidAlifold(20) [ download as .csv ]

Performance of CentroidFold - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidFold

2. Individual counts for CentroidFold [ download as .csv ]