CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	CentroidAlifold(seed)		RNAfold
MCC	0.796	>	0.421
Average MCC ± 95% Confidence Intervals	0.790 ± 0.032	>	0.420 ± 0.032
Sensitivity	0.706	>	0.418
Positive Predictive Value	0.897	>	0.424
Total TP	21223	>	12584
Total TN	79088671	>	79082638
Total FP	3503	<	18800
Total FP CONTRA	450	<	2495
Total FP INCONS	1983	<	14610
Total FP COMP	1070	<	1695
Total FN	8857	<	17496
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of CentroidAlifold(seed) and RNAfold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(seed) and RNAfold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidAlifold(seed) and RNAfold).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(seed) and RNAfold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(seed) and RNAfold).

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Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

Total Base Pair Counts
Total TP	21223
Total TN	79088671
Total FP	3503
Total FP CONTRA	450
Total FP INCONS	1983
Total FP COMP	1070
Total FN	8857

Total Scores
MCC	0.796
Average MCC ± 95% Confidence Intervals	0.790 ± 0.032
Sensitivity	0.706
Positive Predictive Value	0.897
Nr of predictions	64

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2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.90	0.86	0.95	393	1085187	55	6	15	34	65
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.90	368	1141906	52	10	32	10	106
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	385	1170801	38	9	20	9	85
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	374	1107413	39	9	20	10	82
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.92	372	1172342	41	9	23	9	101
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.92	381	1181541	41	9	22	10	95
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	375	1108900	39	9	21	9	82
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.87	0.80	0.93	373	1178481	41	4	22	15	92
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.92	379	1135867	41	9	23	9	84
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	381	1201614	41	9	21	11	95
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	372	1152519	39	9	21	9	94
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	376	1180010	40	9	21	10	95
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.94	374	1190796	41	4	22	15	94
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	340	1082268	59	9	39	11	105
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.84	0.78	0.91	368	1178477	47	9	26	12	105
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	383	1207823	39	9	20	10	92
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	381	1198515	40	9	21	10	97
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	372	1105927	39	9	20	10	81
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.85	0.78	0.92	379	1218731	41	9	22	10	105
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.92	382	1198513	40	9	22	9	96
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	374	1192336	40	9	21	10	94
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	373	1111883	39	9	21	9	82
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.84	0.77	0.90	358	1122354	48	8	31	9	104
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.92	361	1085207	41	8	25	8	85
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.92	371	1114869	40	9	22	9	86
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.90	363	1110392	50	13	27	10	90
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.83	0.77	0.90	347	1129872	48	8	29	11	103
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.92	371	1180013	46	9	23	14	93
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.90	357	1117863	52	9	31	12	96
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.86	0.79	0.92	368	1144943	39	9	21	9	96
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.79	0.73	0.84	316	1015651	66	12	46	8	116
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.90	360	1131361	50	9	30	11	96
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	361	1117862	46	11	26	9	97
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.83	0.77	0.90	367	1189245	50	10	31	9	109
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.76	0.70	0.82	322	1123856	83	13	59	11	139
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.53	0.37	0.77	170	1445629	73	4	47	22	292
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.53	0.37	0.77	177	1579523	74	4	49	21	305
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.54	0.37	0.78	185	1611673	73	4	48	21	311
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.45	0.30	0.69	158	2126723	93	6	66	21	376
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.53	0.37	0.76	182	1615264	78	4	53	21	314
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.52	0.36	0.74	177	1665987	83	5	56	22	318
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	374	1116361	39	8	22	9	84
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	360	1094074	43	2	24	17	85
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	364	1119366	44	2	24	18	88
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.88	0.82	0.94	365	1098513	44	3	22	19	81
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.50	0.35	0.72	168	1636913	92	3	61	28	313
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.85	0.77	0.93	344	1215650	51	2	24	25	102
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.80	0.74	0.87	297	945660	69	2	41	26	107
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.90	303	1201687	92	4	31	57	81
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.92	353	1137401	53	5	27	21	94
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.81	0.74	0.88	291	1152590	94	3	37	54	103
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.45	0.30	0.67	141	1401765	92	7	62	23	329
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.89	358	1117856	57	12	34	11	112
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	377	1135871	39	9	21	9	87
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.48	0.33	0.70	167	1606289	89	4	68	17	336
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.52	0.35	0.77	179	1593773	71	4	49	18	327
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.86	0.81	0.92	351	977520	61	3	27	31	83
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.81	0.72	0.92	356	1073456	57	6	27	24	139
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.78	0.66	0.92	354	1500393	66	5	26	35	181
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.75	0.63	0.90	344	1471089	68	3	34	31	203
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.78	0.65	0.92	368	1606129	52	6	25	21	194
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.79	0.68	0.93	367	1433576	53	2	26	25	173
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.80	0.70	0.92	368	1204728	49	8	24	17	159
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.80	0.71	0.90	348	1117874	63	6	32	25	143

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Performance of RNAfold - scored lower in this pairwise comparison

1. Total counts & total scores for RNAfold

Total Base Pair Counts
Total TP	12584
Total TN	79082638
Total FP	18800
Total FP CONTRA	2495
Total FP INCONS	14610
Total FP COMP	1695
Total FN	17496

Total Scores
MCC	0.421
Average MCC ± 95% Confidence Intervals	0.420 ± 0.032
Sensitivity	0.418
Positive Predictive Value	0.424
Nr of predictions	64

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2. Individual counts for RNAfold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.78	0.76	0.79	350	1085158	132	17	76	39	108
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.63	0.63	0.63	300	1141838	201	31	147	23	174
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.35	0.35	0.36	164	1170755	315	33	263	19	306
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.53	0.52	0.54	238	1107379	215	34	165	16	218
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.60	0.60	0.61	283	1172280	205	23	160	22	190
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.53	0.53	0.53	252	1181474	240	37	190	13	224
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.46	0.46	0.46	210	1108845	266	27	223	16	247
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.47	0.47	0.47	220	1178412	266	29	219	18	245
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.59	270	1135819	209	32	157	20	193
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.61	277	1201568	204	13	167	24	199
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.39	0.38	0.39	179	1152463	296	36	243	17	287
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.54	0.53	0.55	249	1179962	229	32	173	24	222
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.47	0.46	0.47	217	1190733	262	26	220	16	251
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.29	0.29	0.29	131	1082204	330	37	284	9	314
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.42	0.42	0.42	197	1178408	288	34	241	13	276
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.44	0.44	0.44	208	1207762	286	29	236	21	267
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.56	0.54	0.57	259	1198471	217	29	167	21	219
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.39	0.39	0.39	176	1105876	287	34	242	11	277
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.57	0.57	0.58	276	1218664	233	24	177	32	208
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.40	0.40	0.40	190	1198454	296	51	231	14	288
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.41	0.41	0.42	190	1192286	279	40	224	15	278
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.38	0.37	0.40	170	1111856	279	38	222	19	285
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.50	224	1122302	241	35	190	16	238
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.55	0.54	0.55	240	1085168	217	29	164	24	206
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.50	0.49	0.51	226	1114829	235	24	192	19	231
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.37	0.37	0.37	169	1110340	304	41	245	18	284
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.42	0.41	0.43	186	1129828	264	31	211	22	264
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.35	0.34	0.35	157	1179973	303	36	250	17	307
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.50	0.49	0.50	222	1117818	233	28	192	13	231
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.30	0.30	0.29	138	1144872	346	41	290	15	326
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.28	0.28	0.29	120	1015605	317	42	258	17	312
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.28	0.27	0.28	124	1131316	333	36	284	13	332
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.63	0.62	0.63	284	1117810	186	24	142	20	174
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.39	0.38	0.40	181	1189200	291	36	236	19	295
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.30	0.30	0.31	136	1123816	309	46	252	11	325
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.26	0.26	0.25	121	1445372	410	63	294	53	341
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.35	0.36	0.33	174	1579233	393	84	262	47	308
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.33	0.33	0.32	166	1611391	395	72	281	42	330
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.42	0.43	0.41	227	2126398	426	63	265	98	307
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.33	0.34	0.32	169	1614974	406	78	282	46	327
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.28	0.29	0.27	143	1665688	437	80	314	43	352
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.61	0.59	0.62	272	1116326	195	24	143	28	186
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.18	0.18	0.18	78	1094024	373	34	324	15	367
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.31	0.31	0.31	138	1119315	322	37	266	19	314
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.37	0.38	0.37	168	1098447	302	42	246	14	278
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.21	0.22	0.20	105	1636621	473	79	340	54	376
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.22	0.21	0.22	95	1215590	376	51	284	41	351
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.25	0.24	0.25	98	945608	317	41	253	23	306
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.23	0.22	0.23	85	1201662	341	40	238	63	299
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.36	0.36	0.36	161	1137337	307	44	244	19	286
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.22	0.23	0.21	89	1152504	360	53	275	32	305
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.48	0.47	0.48	223	1401508	313	43	201	69	247
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.48	0.48	0.48	225	1117795	263	20	220	23	245
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.62	0.61	0.62	282	1135826	195	25	145	25	182
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.30	0.30	0.30	149	1606023	407	50	306	51	354
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.26	0.27	0.25	136	1593470	434	80	319	35	370
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.37	0.37	0.38	160	977476	278	42	223	13	274
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.48	0.46	0.51	228	1073395	247	19	203	25	267
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.52	0.51	0.53	274	1500261	287	30	213	44	261
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.37	0.36	0.38	196	1470957	345	47	270	28	351
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.54	0.52	0.55	295	1605991	270	35	207	28	267
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.48	0.47	0.49	254	1433456	289	27	234	28	286
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.45	0.43	0.47	228	1204646	269	31	223	15	299
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.49	0.47	0.50	232	1117800	256	26	202	28	259

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

Performance of RNAfold - scored lower in this pairwise comparison

1. Total counts & total scores for RNAfold

2. Individual counts for RNAfold [ download as .csv ]