CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Fold - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Fold & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric Fold Mastr(seed)
MCC 0.351 > 0.000
Average MCC ± 95% Confidence Intervals 0.350 ± 0.570 > 0.000 ± 0.000
Sensitivity 0.359 > 0.000
Positive Predictive Value 0.344 > 0.000
Total TP 527 > 0
Total TN 4973244 < 4974778
Total FP 1243 > 0
Total FP CONTRA 174 > 0
Total FP INCONS 833 > 0
Total FP COMP 236 > 0
Total FN 939 < 1466
P-value 0.0

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Performance plots


  1. Comparison of performance of Fold and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Fold and Mastr(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Fold and Mastr(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Fold and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Fold and Mastr(seed)).

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Performance of Fold - scored higher in this pairwise comparison

1. Total counts & total scores for Fold

Total Base Pair Counts
Total TP 527
Total TN 4973244
Total FP 1243
Total FP CONTRA 174
Total FP INCONS 833
Total FP COMP 236
Total FN 939
Total Scores
MCC 0.351
Average MCC ± 95% Confidence Intervals 0.350 ± 0.570
Sensitivity 0.359
Positive Predictive Value 0.344
Nr of predictions 3

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2. Individual counts for Fold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00306 0.09 0.09 0.08 43 1445337 532 80 390 62 419
CRW_00379 0.44 0.45 0.44 241 2126401 411 60 251 100 293
CRW_00800 0.52 0.52 0.52 243 1401506 300 34 192 74 227

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 0
Total TN 4974778
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 1466
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 3

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00306 0.00 0.00 0.00 0 1445850 0 0 0 0 462
CRW_00379 0.00 0.00 0.00 0 2126953 0 0 0 0 534
CRW_00800 0.00 0.00 0.00 0 1401975 0 0 0 0 470

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.