CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	IPknot		RSpredict(seed)
MCC	0.574	>	0.012
Average MCC ± 95% Confidence Intervals	0.570 ± 0.035	>	0.012 ± 0.003
Sensitivity	0.500	>	0.011
Positive Predictive Value	0.660	>	0.014
Total TP	13451	>	302
Total TN	71040957	>	71039984
Total FP	8173	<	21410
Total FP CONTRA	1081	<	3177
Total FP INCONS	5855	<	17881
Total FP COMP	1237	>	352
Total FN	13453	<	26602
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of IPknot and RSpredict(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for IPknot and RSpredict(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for IPknot and RSpredict(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for IPknot and RSpredict(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for IPknot and RSpredict(seed)).

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Performance of IPknot - scored higher in this pairwise comparison

1. Total counts & total scores for IPknot

Total Base Pair Counts
Total TP	13451
Total TN	71040957
Total FP	8173
Total FP CONTRA	1081
Total FP INCONS	5855
Total FP COMP	1237
Total FN	13453

Total Scores
MCC	0.574
Average MCC ± 95% Confidence Intervals	0.570 ± 0.035
Sensitivity	0.500
Positive Predictive Value	0.660
Nr of predictions	57

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2. Individual counts for IPknot [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.83	0.77	0.89	352	1085204	78	4	41	33	106
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.72	0.63	0.83	297	1170856	75	6	56	13	173
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.58	0.50	0.66	229	1107469	137	16	102	19	227
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.71	0.61	0.83	287	1172399	74	4	56	14	186
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.66	0.60	0.72	287	1181556	121	23	87	11	189
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.59	0.52	0.66	236	1108950	134	23	96	15	221
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.55	0.50	0.60	231	1178495	170	17	137	16	234
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.76	0.68	0.83	317	1135898	79	6	57	16	146
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.70	0.64	0.77	307	1201626	111	11	81	19	169
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.58	0.50	0.68	231	1152582	123	17	91	15	235
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.54	0.48	0.62	225	1180051	148	20	120	8	246
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.61	0.53	0.70	249	1190838	118	6	103	9	219
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.37	0.34	0.40	150	1082284	231	30	192	9	295
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.59	0.53	0.65	252	1178495	145	17	116	12	221
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.61	0.55	0.67	261	1207844	146	17	113	16	214
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.73	0.63	0.85	302	1198569	73	7	48	18	176
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.62	0.53	0.74	239	1106005	96	13	71	12	214
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.76	0.72	0.81	347	1218713	108	15	66	27	137
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.57	0.52	0.63	250	1198526	164	23	127	14	228
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.56	0.44	0.71	207	1192448	104	18	67	19	261
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.66	0.55	0.79	250	1111971	79	11	54	14	205
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.56	0.47	0.66	216	1122424	126	25	86	15	246
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.52	0.47	0.58	208	1085244	163	20	129	14	238
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.76	0.69	0.83	314	1114894	79	11	52	16	143
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.53	0.43	0.66	194	1110503	106	22	76	8	259
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.67	0.58	0.77	265	1117916	90	11	68	11	188
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.65	0.59	0.72	276	1144958	123	17	90	16	188
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.42	0.31	0.56	136	1015781	124	17	91	16	296
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.73	268	1189284	121	17	84	20	208
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.41	0.35	0.48	160	1123920	187	28	142	17	301
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.28	0.24	0.34	109	1445531	252	37	173	42	353
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.37	0.32	0.42	153	1579390	248	42	168	38	329
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.49	0.41	0.59	203	1611565	179	27	115	37	293
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.49	0.40	0.59	214	2126590	218	30	119	69	320
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.40	0.34	0.46	170	1615137	238	31	165	42	326
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.41	0.33	0.51	163	1665906	188	30	126	32	332
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.81	0.75	0.88	344	1116375	69	10	36	23	114
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.44	0.37	0.53	164	1094152	163	21	123	19	281
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.53	0.48	0.59	217	1119386	165	27	126	12	235
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.70	0.63	0.77	282	1098536	110	15	70	25	164
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.28	0.24	0.33	116	1636796	279	54	179	46	365
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.48	0.34	0.67	153	1215790	109	10	67	32	293
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.42	0.29	0.60	111	1201840	104	12	62	30	273
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.55	0.46	0.66	206	1137473	121	11	96	14	241
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.36	0.26	0.50	102	1152715	143	20	84	39	292
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.68	0.63	0.73	295	1117857	132	9	99	24	175
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.68	0.62	0.75	289	1135893	113	17	79	17	175
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.37	0.35	0.40	174	1606096	291	43	215	33	329
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.45	0.41	0.50	207	1593595	240	34	169	37	299
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.50	0.42	0.59	182	977595	134	16	108	10	252
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.64	0.57	0.72	282	1073454	132	13	96	23	213
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.67	0.62	0.73	331	1500326	158	17	104	37	204
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.55	0.46	0.66	252	1471087	150	21	110	19	295
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.62	0.57	0.67	319	1606055	171	20	134	17	243
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.69	0.63	0.76	342	1433519	132	10	100	22	198
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.56	0.48	0.66	252	1204748	138	22	106	10	275
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.61	0.56	0.67	276	1117847	163	10	127	26	215

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Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP	302
Total TN	71039984
Total FP	21410
Total FP CONTRA	3177
Total FP INCONS	17881
Total FP COMP	352
Total FN	26602

Total Scores
MCC	0.012
Average MCC ± 95% Confidence Intervals	0.012 ± 0.003
Sensitivity	0.011
Positive Predictive Value	0.014
Nr of predictions	57

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.00	0.00	0.00	0	1085147	454	58	396	0	458
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.00	0.00	0.00	0	1170823	393	56	336	1	470
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1107442	369	56	309	4	447
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1172351	389	70	316	3	464
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1181549	397	64	331	2	467
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1108929	368	61	306	1	448
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.00	0.00	0.00	0	1178474	406	51	355	0	465
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1135894	379	57	318	4	454
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	10	1201613	405	59	343	3	466
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.00	0.00	0.00	0	1152527	398	50	344	4	466
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.01	0.01	0.01	3	1180016	399	56	341	2	468
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.00	0.00	0.00	0	1190789	408	55	352	1	468
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.00	0.00	0.00	1	1082302	361	46	307	8	444
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.00	0.00	0.00	0	1178475	411	54	351	6	473
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	8	1207825	403	55	347	1	467
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1198522	397	65	330	2	469
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1105951	369	62	306	1	444
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.00	0.00	0.00	0	1218721	423	52	368	3	484
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.00	0.00	0.00	0	1198517	412	51	358	3	478
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.00	0.00	0.00	0	1192358	394	66	316	12	468
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1111909	369	63	305	1	446
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.04	0.03	0.04	16	1122383	354	58	294	2	446
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.03	0.02	0.03	11	1085239	353	59	292	2	435
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1114898	365	61	303	1	448
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.04	0.04	0.04	16	1110429	352	54	296	2	437
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1117885	368	54	312	2	444
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1144967	366	62	303	1	455
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.00	0.00	0.00	0	1015663	366	41	321	4	432
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1189252	396	60	332	4	467
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.03	0.02	0.03	11	1123875	370	46	318	6	450
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1445558	306	53	239	14	462
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1579464	301	50	239	12	482
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1611598	319	50	262	7	496
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	2126581	414	77	295	42	534
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1615206	309	45	252	12	496
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1665933	312	53	239	20	495
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1116386	371	63	307	1	449
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.04	0.04	0.04	16	1094092	354	55	297	2	429
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1119377	371	50	320	1	443
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1098530	368	58	306	4	437
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	1	1636859	310	50	235	25	480
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.00	0.00	0.00	1	1215655	374	61	303	10	445
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1201664	378	83	269	26	375
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1137386	398	62	329	7	438
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.04	0.04	0.04	15	1152569	351	71	266	14	379
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1117886	369	53	312	4	461
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1135900	370	64	305	1	455
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1606225	319	65	238	16	503
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1593701	318	50	254	14	506
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.02	0.02	0.02	9	977518	375	33	341	1	425
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.02	0.02	0.02	9	1073471	365	45	320	0	486
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.00	0.00	0.00	0	1500362	424	57	359	8	535
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.00	0.00	0.00	0	1471050	425	45	375	5	547
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.00	0.00	0.00	1	1606120	411	54	353	4	561
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.00	0.00	0.00	0	1433563	415	44	364	7	540
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.01	0.01	0.01	3	1204725	405	40	360	5	524
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.00	0.00	0.00	0	1117880	384	44	336	4	491

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of IPknot - scored higher in this pairwise comparison

1. Total counts & total scores for IPknot

2. Individual counts for IPknot [ download as .csv ]

Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

2. Individual counts for RSpredict(seed) [ download as .csv ]