CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	MXScarna(seed)		MXScarna(20)
MCC	0.665	>	0.648
Average MCC ± 95% Confidence Intervals	0.668 ± 0.027	>	0.652 ± 0.028
Sensitivity	0.595	>	0.591
Positive Predictive Value	0.743	>	0.712
Total TP	16336	>	16222
Total TN	72152147	>	72151338
Total FP	8016	<	9019
Total FP CONTRA	849	<	987
Total FP INCONS	4799	<	5584
Total FP COMP	2368	<	2448
Total FN	11117	<	11231
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of MXScarna(seed) and MXScarna(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and MXScarna(20)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and MXScarna(20)).
Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and MXScarna(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and MXScarna(20)).

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Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP	16336
Total TN	72152147
Total FP	8016
Total FP CONTRA	849
Total FP INCONS	4799
Total FP COMP	2368
Total FN	11117

Total Scores
MCC	0.665
Average MCC ± 95% Confidence Intervals	0.668 ± 0.027
Sensitivity	0.595
Positive Predictive Value	0.743
Nr of predictions	58

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2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.83	0.81	0.86	369	1085172	112	11	49	52	89
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.68	0.60	0.78	285	1141950	117	9	72	36	189
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.74	0.68	0.82	318	1170827	101	10	60	31	152
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.81	302	1107443	101	13	58	30	154
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.72	0.64	0.81	305	1172369	105	12	60	33	168
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.81	312	1181569	104	11	61	32	164
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.74	0.67	0.82	305	1108933	99	12	55	32	152
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.72	0.65	0.81	301	1178507	110	5	67	38	164
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.81	304	1135902	106	11	61	34	159
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.82	312	1201645	103	12	56	35	164
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.72	0.64	0.81	300	1152549	106	11	61	34	166
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.74	0.68	0.82	319	1180025	107	12	60	35	152
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.73	0.65	0.82	305	1190824	106	6	61	39	163
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.65	0.59	0.72	264	1082289	130	14	89	27	181
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.68	0.61	0.77	287	1178505	117	12	76	29	186
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.76	0.69	0.83	327	1207841	102	11	56	35	148
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.75	0.67	0.83	321	1198539	99	12	54	33	157
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.81	299	1105958	104	12	59	33	154
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.72	0.64	0.81	311	1218757	105	11	62	32	173
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.71	0.64	0.78	307	1198533	120	11	75	34	171
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.74	0.66	0.82	311	1192362	98	11	56	31	157
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.74	0.67	0.82	304	1111915	100	11	56	33	151
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.71	0.64	0.80	295	1122381	105	12	63	30	167
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.72	0.65	0.80	290	1085237	110	10	64	36	156
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.74	0.67	0.82	306	1114897	103	10	58	35	151
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.80	300	1110421	108	12	62	34	153
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.68	0.60	0.78	271	1129907	113	9	69	35	179
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.72	0.64	0.81	299	1180047	107	10	60	37	165
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.70	0.63	0.79	284	1117899	114	10	67	37	169
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.82	305	1144968	102	10	58	34	159
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.73	0.65	0.81	297	1131394	104	10	59	35	159
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.71	0.64	0.79	294	1117886	113	13	67	33	164
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.68	0.60	0.77	287	1189280	118	12	74	32	189
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.42	0.39	0.46	181	1445456	267	46	167	54	281
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.48	0.45	0.51	215	1579331	275	41	166	68	267
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.50	0.47	0.53	232	1611469	276	42	167	67	264
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.36	0.32	0.41	170	2126540	318	50	193	75	364
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.49	0.47	0.52	231	1615062	273	41	169	63	265
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.46	0.43	0.49	213	1665792	286	43	177	66	282
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.74	0.66	0.82	304	1116392	101	11	58	32	154
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.70	0.63	0.79	279	1094105	117	6	70	41	166
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.73	0.65	0.82	294	1119399	104	6	57	41	158
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.74	0.66	0.82	294	1098545	110	6	58	46	152
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.45	0.42	0.48	201	1636722	295	39	183	73	280
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	223	945690	133	6	81	46	181
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.71	0.63	0.80	280	1137437	111	7	62	42	167
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	216	1152623	164	8	74	82	178
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.67	0.59	0.76	279	1117895	114	13	73	28	191
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.72	0.65	0.80	301	1135902	107	11	64	32	163
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.47	0.44	0.50	221	1606085	276	37	185	54	282
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.49	0.46	0.53	231	1593565	264	35	174	55	275
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.66	0.56	0.77	278	1073486	114	9	72	33	217
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.63	0.52	0.77	280	1500414	135	2	82	51	255
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.61	0.49	0.76	269	1471116	131	6	79	46	278
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.57	0.47	0.69	263	1606145	154	8	112	34	299
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.66	0.55	0.80	299	1433595	117	1	76	40	241
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.66	0.56	0.79	296	1204752	112	8	72	32	231
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.69	0.59	0.80	290	1117898	113	9	63	41	201

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Performance of MXScarna(20) - scored lower in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP	16222
Total TN	72151338
Total FP	9019
Total FP CONTRA	987
Total FP INCONS	5584
Total FP COMP	2448
Total FN	11231

Total Scores
MCC	0.648
Average MCC ± 95% Confidence Intervals	0.652 ± 0.028
Sensitivity	0.591
Positive Predictive Value	0.712
Nr of predictions	58

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.84	0.81	0.87	369	1085176	107	10	46	51	89
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.68	0.60	0.77	283	1141947	122	12	74	36	191
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.72	0.67	0.78	317	1170807	127	11	80	36	153
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.68	0.63	0.74	288	1107425	137	16	87	34	168
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.72	0.66	0.78	312	1172344	127	16	74	37	161
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.81	316	1181563	109	13	61	35	160
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.69	0.64	0.74	293	1108909	137	18	85	34	164
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.75	0.68	0.81	318	1178489	108	6	67	35	147
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.76	0.71	0.81	328	1135874	114	12	64	38	135
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.69	0.64	0.75	305	1201619	132	14	87	31	171
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.72	0.65	0.80	303	1152540	113	14	64	35	163
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.76	0.70	0.82	332	1180009	110	11	64	35	139
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.65	0.60	0.71	281	1190800	160	10	105	45	187
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.57	0.52	0.63	232	1082285	168	19	120	29	213
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.62	0.56	0.68	264	1178492	152	16	108	28	209
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.73	0.67	0.80	319	1207837	117	10	69	38	156
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.73	0.67	0.80	319	1198526	122	12	69	41	159
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.73	0.67	0.81	302	1105955	106	13	58	35	151
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.71	0.65	0.77	317	1218729	129	13	82	34	167
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.73	0.67	0.79	321	1198521	119	12	72	35	157
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.70	0.64	0.77	299	1192353	124	11	77	36	169
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.72	0.67	0.77	306	1111891	121	14	75	32	149
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.70	0.65	0.77	298	1122364	122	17	72	33	164
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.68	0.62	0.74	277	1085225	135	13	86	36	169
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.71	0.63	0.80	289	1114908	114	13	61	40	168
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.68	0.63	0.73	286	1110405	132	17	87	28	167
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.71	0.62	0.80	280	1129906	107	12	58	37	170
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.70	0.64	0.77	299	1180027	133	10	80	43	165
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.72	0.66	0.78	301	1117875	125	10	74	41	152
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.71	0.65	0.78	303	1144954	117	13	71	33	161
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.69	0.62	0.77	281	1131397	117	9	73	35	175
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.70	0.64	0.77	292	1117883	123	15	70	38	166
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.62	0.58	0.66	274	1189239	172	18	122	32	202
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.43	0.40	0.46	183	1445453	276	47	167	62	279
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.42	0.40	0.43	195	1579299	332	47	212	73	287
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.49	0.46	0.53	229	1611474	266	39	168	59	267
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.37	0.33	0.42	175	2126532	323	40	206	77	359
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.49	0.46	0.52	227	1615066	271	42	168	61	269
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.39	0.37	0.41	181	1665782	316	50	212	54	314
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.63	0.58	0.69	266	1116382	147	16	101	30	192
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.69	0.62	0.76	277	1094097	130	6	80	44	168
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.72	0.67	0.78	303	1119366	134	11	76	47	149
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.74	0.68	0.81	303	1098531	115	7	62	46	143
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.42	0.40	0.44	191	1636712	314	43	199	72	290
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.60	0.54	0.67	217	945677	148	10	96	42	187
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.67	0.60	0.75	268	1137427	134	8	83	43	179
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.63	0.57	0.71	224	1152605	176	10	82	84	170
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.61	0.55	0.68	260	1117878	154	17	105	32	210
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.74	0.69	0.79	322	1135872	121	12	72	37	142
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.44	0.42	0.46	211	1606072	295	46	199	50	292
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.48	0.45	0.51	229	1593556	274	47	173	54	277
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.69	0.60	0.79	295	1073472	114	10	68	36	200
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.62	0.51	0.75	274	1500415	142	2	87	53	261
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.66	0.56	0.78	308	1471077	135	7	78	50	239
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.61	0.52	0.71	293	1606118	156	16	101	39	269
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.64	0.54	0.75	291	1433583	134	3	94	37	249
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.66	0.57	0.76	302	1204732	134	11	83	40	225
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.69	0.60	0.79	294	1117886	120	10	70	40	197

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

2. Individual counts for MXScarna(seed) [ download as .csv ]

Performance of MXScarna(20) - scored lower in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

2. Individual counts for MXScarna(20) [ download as .csv ]