CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	MXScarna(seed)		Sfold
MCC	0.659	>	0.487
Average MCC ± 95% Confidence Intervals	0.662 ± 0.026	>	0.485 ± 0.032
Sensitivity	0.589	>	0.429
Positive Predictive Value	0.738	>	0.553
Total TP	17728	>	12900
Total TN	79088306	<	79089001
Total FP	8922	<	12006
Total FP CONTRA	930	<	1516
Total FP INCONS	5363	<	8910
Total FP COMP	2629	>	1580
Total FN	12352	<	17180
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of MXScarna(seed) and Sfold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and Sfold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and Sfold).
Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and Sfold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and Sfold).

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Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP	17728
Total TN	79088306
Total FP	8922
Total FP CONTRA	930
Total FP INCONS	5363
Total FP COMP	2629
Total FN	12352

Total Scores
MCC	0.659
Average MCC ± 95% Confidence Intervals	0.662 ± 0.026
Sensitivity	0.589
Positive Predictive Value	0.738
Nr of predictions	64

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2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.83	0.81	0.86	369	1085172	112	11	49	52	89
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.68	0.60	0.78	285	1141950	117	9	72	36	189
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.74	0.68	0.82	318	1170827	101	10	60	31	152
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.81	302	1107443	101	13	58	30	154
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.72	0.64	0.81	305	1172369	105	12	60	33	168
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.81	312	1181569	104	11	61	32	164
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.74	0.67	0.82	305	1108933	99	12	55	32	152
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.72	0.65	0.81	301	1178507	110	5	67	38	164
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.81	304	1135902	106	11	61	34	159
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.82	312	1201645	103	12	56	35	164
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.72	0.64	0.81	300	1152549	106	11	61	34	166
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.74	0.68	0.82	319	1180025	107	12	60	35	152
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.73	0.65	0.82	305	1190824	106	6	61	39	163
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.65	0.59	0.72	264	1082289	130	14	89	27	181
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.68	0.61	0.77	287	1178505	117	12	76	29	186
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.76	0.69	0.83	327	1207841	102	11	56	35	148
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.75	0.67	0.83	321	1198539	99	12	54	33	157
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.81	299	1105958	104	12	59	33	154
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.72	0.64	0.81	311	1218757	105	11	62	32	173
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.71	0.64	0.78	307	1198533	120	11	75	34	171
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.74	0.66	0.82	311	1192362	98	11	56	31	157
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.74	0.67	0.82	304	1111915	100	11	56	33	151
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.71	0.64	0.80	295	1122381	105	12	63	30	167
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.72	0.65	0.80	290	1085237	110	10	64	36	156
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.74	0.67	0.82	306	1114897	103	10	58	35	151
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.80	300	1110421	108	12	62	34	153
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.68	0.60	0.78	271	1129907	113	9	69	35	179
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.72	0.64	0.81	299	1180047	107	10	60	37	165
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.70	0.63	0.79	284	1117899	114	10	67	37	169
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.73	0.66	0.82	305	1144968	102	10	58	34	159
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.63	0.56	0.71	242	1015684	127	13	86	28	190
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.73	0.65	0.81	297	1131394	104	10	59	35	159
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.71	0.64	0.79	294	1117886	113	13	67	33	164
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.68	0.60	0.77	287	1189280	118	12	74	32	189
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.62	0.53	0.71	245	1123906	126	12	87	27	216
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.42	0.39	0.46	181	1445456	267	46	167	54	281
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.48	0.45	0.51	215	1579331	275	41	166	68	267
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.50	0.47	0.53	232	1611469	276	42	167	67	264
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.36	0.32	0.41	170	2126540	318	50	193	75	364
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.49	0.47	0.52	231	1615062	273	41	169	63	265
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.46	0.43	0.49	213	1665792	286	43	177	66	282
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.74	0.66	0.82	304	1116392	101	11	58	32	154
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.70	0.63	0.79	279	1094105	117	6	70	41	166
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.73	0.65	0.82	294	1119399	104	6	57	41	158
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.74	0.66	0.82	294	1098545	110	6	58	46	152
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.45	0.42	0.48	201	1636722	295	39	183	73	280
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.68	0.59	0.78	262	1215683	119	6	69	44	184
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	223	945690	133	6	81	46	181
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.73	212	1201733	150	4	76	70	172
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.71	0.63	0.80	280	1137437	111	7	62	42	167
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	216	1152623	164	8	74	82	178
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.34	0.29	0.39	137	1401627	256	36	175	45	333
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.67	0.59	0.76	279	1117895	114	13	73	28	191
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.72	0.65	0.80	301	1135902	107	11	64	32	163
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.47	0.44	0.50	221	1606085	276	37	185	54	282
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.49	0.46	0.53	231	1593565	264	35	174	55	275
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.73	0.68	0.78	294	977526	128	10	71	47	140
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.66	0.56	0.77	278	1073486	114	9	72	33	217
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.63	0.52	0.77	280	1500414	135	2	82	51	255
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.61	0.49	0.76	269	1471116	131	6	79	46	278
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.57	0.47	0.69	263	1606145	154	8	112	34	299
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.66	0.55	0.80	299	1433595	117	1	76	40	241
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.66	0.56	0.79	296	1204752	112	8	72	32	231
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.69	0.59	0.80	290	1117898	113	9	63	41	201

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Performance of Sfold - scored lower in this pairwise comparison

1. Total counts & total scores for Sfold

Total Base Pair Counts
Total TP	12900
Total TN	79089001
Total FP	12006
Total FP CONTRA	1516
Total FP INCONS	8910
Total FP COMP	1580
Total FN	17180

Total Scores
MCC	0.487
Average MCC ± 95% Confidence Intervals	0.485 ± 0.032
Sensitivity	0.429
Positive Predictive Value	0.553
Nr of predictions	64

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2. Individual counts for Sfold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.80	0.77	0.83	352	1085176	112	13	60	39	106
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.65	0.64	0.66	304	1141856	180	27	129	24	170
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.50	0.45	0.54	213	1170824	198	17	161	20	257
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.48	0.43	0.54	195	1107453	185	23	145	17	261
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.54	0.49	0.60	232	1172361	169	19	134	16	241
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.49	0.45	0.54	215	1181555	193	31	152	10	261
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.48	0.43	0.53	196	1108938	184	19	152	13	261
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.59	0.55	0.63	258	1178469	180	16	137	27	207
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.66	0.60	0.73	280	1135893	125	10	95	20	183
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.63	0.57	0.70	272	1201636	139	16	101	22	204
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.40	0.37	0.44	171	1152531	233	30	189	14	295
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.67	0.61	0.74	287	1180029	118	21	79	18	184
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.54	0.47	0.61	221	1190832	160	15	128	17	247
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.36	0.32	0.39	144	1082291	233	16	205	12	301
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.45	0.41	0.50	195	1178491	206	27	167	12	278
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.47	0.44	0.50	210	1207811	232	23	191	18	265
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.61	0.53	0.70	254	1198565	129	7	100	22	224
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.54	0.45	0.66	202	1106023	115	16	87	12	251
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.58	0.57	0.59	274	1218677	223	21	169	33	210
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.50	0.46	0.54	221	1198516	206	28	161	17	257
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.37	0.33	0.42	155	1192370	232	35	180	17	313
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.48	0.39	0.59	178	1111985	137	19	104	14	277
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.49	0.43	0.57	198	1122402	170	32	119	19	264
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.55	0.50	0.61	224	1085232	162	22	123	17	222
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.58	0.47	0.73	213	1114978	98	14	66	18	244
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.40	0.30	0.54	136	1110544	127	18	97	12	317
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.51	0.37	0.70	166	1130018	88	6	66	16	284
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.61	0.54	0.69	252	1180052	131	20	92	19	212
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.60	0.55	0.66	250	1117881	149	21	108	20	203
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.68	0.60	0.77	279	1144977	109	11	74	24	185
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.31	0.24	0.40	102	1015772	167	19	132	16	330
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.42	0.33	0.53	149	1131480	147	20	111	16	307
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.77	0.71	0.83	326	1117866	94	16	52	26	132
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.59	0.51	0.68	241	1189298	141	19	95	27	235
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.36	0.31	0.41	142	1123904	219	35	169	15	319
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.21	0.19	0.24	88	1445476	332	57	229	46	374
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.36	0.35	0.36	169	1579286	334	74	224	36	313
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.38	0.34	0.42	171	1611504	271	50	185	36	325
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.44	0.34	0.58	183	2126636	205	17	117	71	351
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.39	0.32	0.47	157	1615171	217	28	147	42	339
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.33	0.29	0.38	146	1665840	278	40	199	39	349
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.57	0.54	0.61	247	1116358	185	18	142	25	211
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.31	0.26	0.36	116	1094139	220	19	186	15	329
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.58	0.40	0.84	179	1119542	50	5	30	15	273
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.60	0.56	0.65	248	1098523	153	22	110	21	198
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.23	0.22	0.25	105	1636722	354	42	276	36	376
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.33	0.28	0.40	124	1215709	234	16	171	47	322
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.30	0.27	0.34	108	945681	233	27	184	22	296
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.42	0.29	0.62	111	1201847	113	3	64	46	273
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.40	0.34	0.46	152	1137458	193	30	146	17	295
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.19	0.17	0.20	68	1152586	311	44	223	44	326
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.52	0.46	0.59	215	1401613	204	32	115	57	255
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.50	0.48	0.52	227	1117826	230	18	189	23	243
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.59	0.52	0.66	241	1135913	144	19	105	20	223
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.37	0.30	0.45	152	1606193	221	35	148	38	351
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.33	0.29	0.38	149	1593608	285	55	193	37	357
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.37	0.34	0.41	147	977541	224	31	182	11	287
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.52	0.46	0.58	229	1073451	189	12	153	24	266
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.54	0.49	0.60	263	1500337	220	22	156	42	272
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.38	0.32	0.47	173	1471098	222	33	166	23	374
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.56	0.50	0.63	280	1606082	191	20	146	25	282
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.60	0.53	0.67	288	1433540	169	14	129	26	252
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.55	0.44	0.70	230	1204799	110	12	87	11	297
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.50	0.46	0.54	227	1117836	223	19	178	26	264

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

2. Individual counts for MXScarna(seed) [ download as .csv ]

Performance of Sfold - scored lower in this pairwise comparison

1. Total counts & total scores for Sfold

2. Individual counts for Sfold [ download as .csv ]