CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(20) - scored higher in this pairwise comparison

  4. Performance of CRWrnafold - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(20) & CRWrnafold [.zip] - may take several seconds...


Overview

Metric Murlet(20) CRWrnafold
MCC 0.771 > 0.531
Average MCC ± 95% Confidence Intervals 0.771 ± 0.052 > 0.530 ± 0.320
Sensitivity 0.702 > 0.522
Positive Predictive Value 0.847 > 0.541
Total TP 948 > 705
Total TN 3385183 > 3384998
Total FP 229 < 666
Total FP CONTRA 31 < 70
Total FP INCONS 140 < 529
Total FP COMP 58 < 67
Total FN 402 < 645
P-value 0.0

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Performance plots


  1. Comparison of performance of Murlet(20) and CRWrnafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and CRWrnafold).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and CRWrnafold).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and CRWrnafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and CRWrnafold).

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Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 948
Total TN 3385183
Total FP 229
Total FP CONTRA 31
Total FP INCONS 140
Total FP COMP 58
Total FN 402
Total Scores
MCC 0.771
Average MCC ± 95% Confidence Intervals 0.771 ± 0.052
Sensitivity 0.702
Positive Predictive Value 0.847
Nr of predictions 3

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00278 0.75 0.67 0.83 302 1129893 75 12 49 14 148
CRW_00280 0.78 0.72 0.85 328 1117874 75 11 47 17 125
CRW_00789 0.78 0.71 0.86 318 1137416 79 8 44 27 129

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Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

Total Base Pair Counts
Total TP 705
Total TN 3384998
Total FP 666
Total FP CONTRA 70
Total FP INCONS 529
Total FP COMP 67
Total FN 645
Total Scores
MCC 0.531
Average MCC ± 95% Confidence Intervals 0.530 ± 0.320
Sensitivity 0.522
Positive Predictive Value 0.541
Nr of predictions 3

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2. Individual counts for CRWrnafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00278 0.41 0.40 0.42 182 1129824 270 20 230 20 268
CRW_00280 0.67 0.66 0.68 299 1117818 160 18 125 17 154
CRW_00789 0.51 0.50 0.52 224 1137356 236 32 174 30 223

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.