CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(20) - scored higher in this pairwise comparison

  4. Performance of Carnac(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(20) & Carnac(20) [.zip] - may take several seconds...


Overview

Metric Murlet(20) Carnac(20)
MCC 0.621 > 0.528
Average MCC ± 95% Confidence Intervals 0.620 ± 0.161 > 0.520 ± 0.097
Sensitivity 0.544 > 0.320
Positive Predictive Value 0.708 < 0.872
Total TP 2368 > 1391
Total TN 12465477 < 12467227
Total FP 1159 > 318
Total FP CONTRA 149 > 18
Total FP INCONS 828 > 186
Total FP COMP 182 > 114
Total FN 1981 < 2958
P-value 0.0

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Performance plots


  1. Comparison of performance of Murlet(20) and Carnac(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and Carnac(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and Carnac(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and Carnac(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and Carnac(20)).

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Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 2368
Total TN 12465477
Total FP 1159
Total FP CONTRA 149
Total FP INCONS 828
Total FP COMP 182
Total FN 1981
Total Scores
MCC 0.621
Average MCC ± 95% Confidence Intervals 0.620 ± 0.161
Sensitivity 0.544
Positive Predictive Value 0.708
Nr of predictions 9

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00177 0.75 0.70 0.81 330 1178473 93 14 63 16 143
CRW_00250 0.75 0.68 0.84 325 1198537 73 14 50 9 153
CRW_00278 0.75 0.67 0.83 302 1129893 75 12 49 14 148
CRW_00280 0.78 0.72 0.85 328 1117874 75 11 47 17 125
CRW_00330 0.39 0.31 0.49 160 1988690 189 26 139 24 357
CRW_00411 0.31 0.25 0.40 122 1615195 206 23 163 20 374
CRW_00414 0.33 0.29 0.36 146 1665818 288 38 223 27 349
CRW_00789 0.78 0.71 0.86 318 1137416 79 8 44 27 129
PDB_01105 0.73 0.62 0.86 337 1433581 81 3 50 28 203

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Performance of Carnac(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 1391
Total TN 12467227
Total FP 318
Total FP CONTRA 18
Total FP INCONS 186
Total FP COMP 114
Total FN 2958
Total Scores
MCC 0.528
Average MCC ± 95% Confidence Intervals 0.520 ± 0.097
Sensitivity 0.320
Positive Predictive Value 0.872
Nr of predictions 9

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00177 0.52 0.32 0.87 149 1178708 29 3 20 6 324
CRW_00250 0.68 0.50 0.91 241 1198660 33 4 21 8 237
CRW_00278 0.52 0.29 0.92 130 1130115 15 4 7 4 320
CRW_00280 0.66 0.46 0.96 209 1118042 12 1 8 3 244
CRW_00330 0.34 0.17 0.67 89 1988883 69 3 40 26 428
CRW_00411 0.39 0.19 0.81 94 1615387 42 0 22 20 402
CRW_00414 0.38 0.19 0.74 96 1666095 60 1 33 26 399
CRW_00789 0.61 0.43 0.88 191 1137570 34 1 24 9 256
PDB_01105 0.58 0.36 0.94 192 1433767 24 1 11 12 348

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.