CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	Murlet(20)		Fold
MCC	0.621	>	0.371
Average MCC ± 95% Confidence Intervals	0.620 ± 0.161	>	0.372 ± 0.050
Sensitivity	0.544	>	0.375
Positive Predictive Value	0.708	>	0.368
Total TP	2368	>	1629
Total TN	12465477	>	12464395
Total FP	1159	<	3110
Total FP CONTRA	149	<	421
Total FP INCONS	828	<	2377
Total FP COMP	182	<	312
Total FN	1981	<	2720
P-value	0.0

Comparison of performance of Murlet(20) and Fold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and Fold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and Fold).
Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and Fold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and Fold).

Total Scores
MCC	0.621
Average MCC ± 95% Confidence Intervals	0.620 ± 0.161
Sensitivity	0.544
Positive Predictive Value	0.708
Nr of predictions	9

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.75	0.70	0.81	330	1178473	93	14	63	16	143
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.75	0.68	0.84	325	1198537	73	14	50	9	153
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.75	0.67	0.83	302	1129893	75	12	49	14	148
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.78	0.72	0.85	328	1117874	75	11	47	17	125
CRW_00330	SSU_rRNA_eukarya links to Rfam database...	0.39	0.31	0.49	160	1988690	189	26	139	24	357
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.31	0.25	0.40	122	1615195	206	23	163	20	374
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.33	0.29	0.36	146	1665818	288	38	223	27	349
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.78	0.71	0.86	318	1137416	79	8	44	27	129
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.73	0.62	0.86	337	1433581	81	3	50	28	203

Total Scores
MCC	0.371
Average MCC ± 95% Confidence Intervals	0.372 ± 0.050
Sensitivity	0.375
Positive Predictive Value	0.368
Nr of predictions	9

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.50	226	1178426	251	26	202	23	247
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.37	0.38	0.37	181	1198432	321	48	265	8	297
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.36	0.35	0.37	159	1129828	293	31	238	24	291
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.33	0.33	0.32	151	1117794	327	43	272	12	302
CRW_00330	SSU_rRNA_eukarya links to Rfam database...	0.31	0.32	0.30	166	1988453	469	82	314	73	351
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.35	0.36	0.34	177	1614982	392	60	284	48	319
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.29	0.31	0.28	152	1665688	448	68	317	63	343
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.39	0.38	0.39	172	1137342	303	31	241	31	275
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.46	0.45	0.47	245	1433450	306	32	244	30	295

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.