CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PETfold_pre2.0(20)		Afold
MCC	0.729	>	0.410
Average MCC ± 95% Confidence Intervals	0.731 ± 0.031	>	0.413 ± 0.031
Sensitivity	0.698	>	0.410
Positive Predictive Value	0.761	>	0.411
Total TP	24459	>	14374
Total TN	99028809	>	99025973
Total FP	10453	<	23038
Total FP CONTRA	1276	<	3302
Total FP INCONS	6388	<	17283
Total FP COMP	2789	>	2453
Total FN	10604	<	20689
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of PETfold_pre2.0(20) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(20) and Afold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(20) and Afold).
Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(20) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(20) and Afold).

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Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(20)

Total Base Pair Counts
Total TP	24459
Total TN	99028809
Total FP	10453
Total FP CONTRA	1276
Total FP INCONS	6388
Total FP COMP	2789
Total FN	10604

Total Scores
MCC	0.729
Average MCC ± 95% Confidence Intervals	0.731 ± 0.031
Sensitivity	0.698
Positive Predictive Value	0.761
Nr of predictions	73

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2. Individual counts for PETfold_pre2.0(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.89	0.88	0.90	404	1085151	82	10	36	36	54
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.84	0.83	0.84	390	1170753	91	18	54	19	80
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.84	0.84	0.84	381	1107361	95	17	57	21	75
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.85	390	1172289	85	17	50	18	83
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.86	390	1181501	85	16	46	23	86
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.84	0.84	0.84	383	1108851	87	16	55	16	74
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.85	0.83	0.87	388	1178436	81	12	44	25	77
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.85	0.84	0.86	388	1135827	85	15	48	22	75
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.83	0.81	0.85	387	1201568	90	18	52	20	89
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.83	0.82	0.85	381	1152473	90	16	51	23	85
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.83	0.81	0.85	381	1179968	89	17	50	22	90
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.85	0.83	0.86	387	1190748	90	11	50	29	81
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.80	0.80	0.81	354	1082220	107	18	64	25	91
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.82	0.81	0.84	382	1178424	101	17	57	27	91
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.83	0.81	0.85	387	1207780	91	16	52	23	88
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.85	0.82	0.87	394	1198472	81	16	44	21	84
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.87	0.86	0.87	390	1105881	79	17	40	22	63
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.87	396	1218684	87	15	46	26	88
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.83	0.80	0.85	382	1198478	88	15	51	22	96
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.83	0.81	0.85	379	1192296	87	16	49	22	89
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.86	0.86	0.86	390	1111833	85	15	48	22	65
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.82	0.81	0.84	375	1122302	98	14	60	24	87
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.84	0.84	0.84	375	1085156	94	14	56	24	71
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.86	0.86	0.87	391	1114821	86	15	44	27	66
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.84	0.84	0.85	379	1110348	89	16	52	21	74
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.86	371	1129827	85	12	46	27	79
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.82	0.81	0.84	377	1179965	98	18	56	24	87
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.85	0.85	0.86	384	1117811	93	15	50	28	69
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.85	381	1144895	89	14	51	24	83
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.85	376	1131317	94	16	51	27	80
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.84	0.83	0.86	380	1117816	91	17	47	27	78
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.83	0.81	0.85	386	1189199	95	13	55	27	90
CRW_00298	SSU_rRNA_eukarya links to Rfam database...	0.58	0.54	0.63	267	1620473	212	31	129	52	227
CRW_00301	SSU_rRNA_eukarya links to Rfam database...	0.49	0.46	0.53	240	1762048	265	37	178	50	279
CRW_00310	SSU_rRNA_eukarya links to Rfam database...	0.55	0.51	0.59	264	1805500	238	32	154	52	257
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.64	0.60	0.68	299	1627669	193	22	120	51	203
CRW_00330	SSU_rRNA_eukarya links to Rfam database...	0.55	0.51	0.60	262	1988577	231	26	150	55	255
CRW_00332	SSU_rRNA_eukarya links to Rfam database...	0.51	0.48	0.56	227	1769613	237	20	161	56	250
CRW_00333	SSU_rRNA_eukarya links to Rfam database...	0.48	0.43	0.53	220	1892069	260	36	160	64	294
CRW_00345	SSU_rRNA_eukarya links to Rfam database...	0.56	0.53	0.60	262	1586434	224	28	147	49	236
CRW_00348	SSU_rRNA_eukarya links to Rfam database...	0.58	0.54	0.61	272	1615059	225	29	143	53	231
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.56	0.53	0.60	269	1674914	228	29	153	46	238
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.60	0.56	0.64	269	1579331	210	25	128	57	213
CRW_00370	SSU_rRNA_eukarya links to Rfam database...	0.60	0.57	0.64	288	1640315	211	20	143	48	218
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.58	0.55	0.60	275	1611455	232	17	163	52	221
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.59	0.55	0.62	275	1625865	212	23	143	46	223
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.58	0.52	0.65	277	2126526	213	25	125	63	257
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.49	0.46	0.53	236	1750812	258	28	180	50	279
CRW_00403	SSU_rRNA_eukarya links to Rfam database...	0.53	0.52	0.54	240	1606084	283	31	173	79	224
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.58	0.54	0.61	269	1615064	222	21	149	52	227
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.57	0.53	0.62	263	1665801	210	25	136	49	232
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.85	0.85	0.85	388	1116310	90	13	54	23	70
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.86	367	1094034	98	8	51	39	78
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.87	0.84	0.89	381	1119329	87	4	42	41	71
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.85	0.84	0.86	373	1098469	103	7	54	42	73
CRW_00598	SSU_rRNA_eukarya links to Rfam database...	0.54	0.51	0.58	250	1665793	234	28	154	52	241
CRW_00758	SSU_rRNA_eukarya links to Rfam database...	0.57	0.54	0.61	263	1640333	241	27	143	71	220
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.56	0.53	0.59	254	1636715	232	18	158	56	227
CRW_00760	SSU_rRNA_eukarya links to Rfam database...	0.53	0.49	0.57	239	1638533	247	16	167	64	247
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.78	0.76	0.80	306	945618	127	7	69	51	98
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.82	0.80	0.85	357	1137365	108	8	56	44	90
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.79	0.76	0.82	301	1152552	149	5	63	81	93
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.80	0.78	0.82	366	1117816	101	14	64	23	104
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.59	0.56	0.63	283	1606076	220	25	144	51	220
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.52	0.48	0.56	245	1593566	240	31	163	46	261
CRW_01300	SSU_rRNA_eukarya links to Rfam database...	0.60	0.55	0.67	283	1693295	193	17	125	51	232
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.78	0.72	0.84	355	1073423	101	6	61	34	140
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.75	0.68	0.84	363	1500344	118	10	61	47	172
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.74	0.65	0.83	357	1471042	115	5	66	44	190
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.75	0.66	0.85	373	1606088	99	8	59	32	189
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.75	0.68	0.84	366	1433533	107	4	68	35	174
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.78	0.72	0.85	378	1204681	101	9	60	32	149
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.78	0.73	0.84	358	1117834	110	9	59	42	133

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Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP	14374
Total TN	99025973
Total FP	23038
Total FP CONTRA	3302
Total FP INCONS	17283
Total FP COMP	2453
Total FN	20689

Total Scores
MCC	0.410
Average MCC ± 95% Confidence Intervals	0.413 ± 0.031
Sensitivity	0.410
Positive Predictive Value	0.411
Nr of predictions	73

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2. Individual counts for Afold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.78	0.77	0.79	351	1085158	132	17	75	40	107
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.50	228	1170758	252	20	209	23	242
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.46	0.46	0.46	208	1107368	260	31	209	20	248
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.52	0.51	0.53	240	1172289	233	26	191	16	233
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.55	0.54	0.55	259	1181483	231	27	184	20	217
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.50	226	1108849	247	24	206	17	231
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.46	0.46	0.47	214	1178420	264	32	214	18	251
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.64	0.63	0.64	291	1135826	182	20	141	21	172
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.60	274	1201566	212	26	159	27	202
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.42	0.41	0.42	193	1152465	282	35	228	19	273
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.64	0.62	0.65	293	1179965	180	30	128	22	178
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.54	0.53	0.55	248	1190745	226	28	175	23	220
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.29	0.29	0.29	127	1082216	323	37	276	10	318
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.44	0.43	0.45	203	1178433	259	22	222	15	270
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.47	0.46	0.48	220	1207772	267	24	219	24	255
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.57	0.56	0.58	266	1198467	216	21	172	23	212
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.38	0.38	0.38	172	1105880	289	44	232	13	281
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.57	0.57	0.58	274	1218666	234	21	180	33	210
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.44	0.44	0.45	210	1198459	274	34	223	17	268
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.42	188	1192291	278	39	222	17	280
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.44	0.43	0.45	196	1111850	260	40	200	20	259
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.51	231	1122302	237	43	175	19	231
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.60	258	1085174	195	26	143	26	188
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.47	0.47	0.48	213	1114826	258	28	204	26	244
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.38	0.38	0.38	172	1110338	300	45	240	15	281
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.42	180	1129825	274	33	218	23	270
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.51	0.49	0.53	229	1179985	227	29	173	25	235
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.51	227	1117817	231	28	188	15	226
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.30	0.30	0.29	138	1144872	347	41	290	16	326
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.28	0.27	0.28	124	1131316	337	30	290	17	332
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.72	0.71	0.74	325	1117819	142	23	93	26	133
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.46	0.45	0.48	214	1189204	258	34	201	23	262
CRW_00298	SSU_rRNA_eukarya links to Rfam database...	0.19	0.20	0.18	99	1620353	490	81	367	42	395
CRW_00301	SSU_rRNA_eukarya links to Rfam database...	0.30	0.31	0.30	162	1761957	428	86	298	44	357
CRW_00310	SSU_rRNA_eukarya links to Rfam database...	0.29	0.30	0.28	157	1805386	453	81	326	46	364
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.41	0.41	0.42	204	1627621	339	47	238	54	298
CRW_00330	SSU_rRNA_eukarya links to Rfam database...	0.32	0.32	0.31	167	1988474	452	69	305	78	350
CRW_00332	SSU_rRNA_eukarya links to Rfam database...	0.18	0.20	0.17	94	1769479	492	105	343	44	383
CRW_00333	SSU_rRNA_eukarya links to Rfam database...	0.29	0.30	0.28	153	1891946	449	74	312	63	361
CRW_00345	SSU_rRNA_eukarya links to Rfam database...	0.34	0.35	0.33	175	1586340	403	71	285	47	323
CRW_00348	SSU_rRNA_eukarya links to Rfam database...	0.25	0.25	0.24	127	1614982	437	68	326	43	376
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.36	0.36	0.35	183	1674845	391	61	276	54	324
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.35	0.36	0.33	174	1579230	395	88	261	46	308
CRW_00370	SSU_rRNA_eukarya links to Rfam database...	0.28	0.28	0.28	143	1640248	420	77	298	45	363
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.29	0.29	0.28	145	1611389	409	77	299	33	351
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.36	0.36	0.35	181	1625787	378	59	279	40	317
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.42	0.43	0.41	227	2126401	423	55	270	98	307
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.24	0.25	0.23	129	1750683	478	83	361	34	386
CRW_00403	SSU_rRNA_eukarya links to Rfam database...	0.31	0.31	0.30	146	1606035	431	65	282	84	318
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.34	0.34	0.34	169	1615006	381	62	266	53	327
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.27	0.28	0.26	140	1665694	436	77	314	45	355
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.60	0.59	0.62	268	1116330	196	21	146	29	190
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.18	0.18	0.18	78	1094024	374	34	324	16	367
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.36	0.36	0.37	161	1119326	290	30	239	21	291
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.57	0.56	0.59	251	1098476	205	23	153	29	195
CRW_00598	SSU_rRNA_eukarya links to Rfam database...	0.31	0.33	0.29	162	1665675	440	88	300	52	329
CRW_00758	SSU_rRNA_eukarya links to Rfam database...	0.29	0.30	0.29	144	1640268	416	66	288	62	339
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.22	0.22	0.21	107	1636633	462	78	327	57	374
CRW_00760	SSU_rRNA_eukarya links to Rfam database...	0.28	0.29	0.28	140	1638458	411	74	283	54	346
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.26	0.25	0.26	103	945610	313	37	250	26	301
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.36	0.36	0.36	160	1137342	302	44	240	18	287
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.21	0.22	0.21	85	1152511	379	51	274	54	309
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.49	227	1117798	259	23	212	24	243
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.32	0.32	0.32	160	1606024	390	54	290	46	343
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.32	0.33	0.31	167	1593473	402	81	284	37	339
CRW_01300	SSU_rRNA_eukarya links to Rfam database...	0.36	0.37	0.35	189	1693186	392	71	274	47	326
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.53	0.50	0.56	246	1073408	220	17	174	29	249
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.55	0.53	0.56	284	1500271	276	22	201	53	251
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.36	0.35	0.37	191	1470959	352	45	275	32	356
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.56	0.54	0.58	306	1605999	254	32	191	31	256
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.60	0.58	0.63	313	1433471	221	15	172	34	227
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.46	0.43	0.49	228	1204659	250	31	210	9	299
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.51	0.48	0.53	237	1117812	242	21	190	31	254

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(20)

2. Individual counts for PETfold_pre2.0(20) [ download as .csv ]

Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

2. Individual counts for Afold [ download as .csv ]