CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PETfold_pre2.0(seed)		CRWrnafold
MCC	0.836	>	0.515
Average MCC ± 95% Confidence Intervals	0.836 ± 0.013	>	0.512 ± 0.050
Sensitivity	0.819	>	0.508
Positive Predictive Value	0.854	>	0.523
Total TP	10742	>	6664
Total TN	32000901	>	32000733
Total FP	3068	<	6747
Total FP CONTRA	390	<	823
Total FP INCONS	1445	<	5258
Total FP COMP	1233	>	666
Total FN	2369	<	6447
P-value	5.1503931209e-08

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Performance plots

Comparison of performance of PETfold_pre2.0(seed) and CRWrnafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and CRWrnafold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and CRWrnafold).
Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and CRWrnafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and CRWrnafold).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP	10742
Total TN	32000901
Total FP	3068
Total FP CONTRA	390
Total FP INCONS	1445
Total FP COMP	1233
Total FN	2369

Total Scores
MCC	0.836
Average MCC ± 95% Confidence Intervals	0.836 ± 0.013
Sensitivity	0.819
Positive Predictive Value	0.854
Nr of predictions	29

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.86	0.86	0.87	390	1107367	95	16	43	36	66
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.86	0.86	0.87	394	1108851	94	17	43	34	63
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.85	0.84	0.86	387	1135829	97	15	47	35	76
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.80	0.79	0.81	353	1082222	118	17	64	37	92
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.86	0.86	0.87	388	1105880	95	18	42	35	65
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.87	0.86	0.87	391	1111838	94	15	42	37	64
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.83	0.82	0.85	378	1122307	105	14	52	39	84
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.86	0.85	0.86	380	1085161	98	14	46	38	66
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.86	0.85	0.87	390	1114823	98	15	43	40	67
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.84	0.83	0.85	377	1110354	101	16	48	37	76
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.85	369	1129823	106	15	49	42	81
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.84	0.83	0.85	377	1117815	109	16	52	41	76
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.85	0.84	0.87	388	1144894	97	16	43	38	76
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.78	0.77	0.80	331	1015610	118	18	66	34	101
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.83	0.82	0.84	372	1131319	111	16	53	42	84
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.85	377	1117816	104	17	50	37	81
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.74	0.72	0.77	332	1123817	133	22	79	32	129
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.86	0.85	0.87	391	1116315	99	14	45	40	67
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.87	0.84	0.89	376	1094037	99	6	41	52	69
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.87	0.84	0.89	381	1119327	104	6	42	56	71
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.87	0.86	0.89	382	1098473	103	6	42	55	64
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.79	0.76	0.81	309	945618	130	6	67	57	95
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.84	0.83	0.85	317	1201654	139	6	48	85	67
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.83	0.81	0.86	362	1137365	112	11	48	53	85
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.79	0.76	0.81	359	1117819	116	16	66	34	111
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.86	0.85	0.87	395	1135823	93	17	43	33	69
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.87	0.85	0.89	367	977489	81	8	37	36	67
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.79	0.73	0.86	361	1073423	107	9	52	46	134
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.80	0.75	0.86	368	1117832	112	8	52	52	123

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Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

Total Base Pair Counts
Total TP	6664
Total TN	32000733
Total FP	6747
Total FP CONTRA	823
Total FP INCONS	5258
Total FP COMP	666
Total FN	6447

Total Scores
MCC	0.515
Average MCC ± 95% Confidence Intervals	0.512 ± 0.050
Sensitivity	0.508
Positive Predictive Value	0.523
Nr of predictions	29

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2. Individual counts for CRWrnafold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.57	0.56	0.57	257	1107367	210	22	170	18	199
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.57	0.57	0.58	259	1108856	209	20	170	19	198
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.48	226	1135811	256	30	211	15	237
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.38	0.38	0.39	168	1082220	282	31	237	14	277
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.53	0.53	0.54	240	1105883	225	26	179	20	213
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.50	225	1111832	246	27	202	17	230
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.69	0.67	0.71	311	1122312	152	21	107	24	151
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.41	0.41	0.41	181	1085155	279	39	226	14	265
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.65	0.65	0.66	296	1114820	177	28	127	22	161
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.44	0.43	0.44	196	1110351	263	35	213	15	257
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.42	182	1129824	270	20	230	20	268
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.67	0.66	0.68	299	1117818	160	18	125	17	154
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.60	0.59	0.61	274	1144893	197	27	147	23	190
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.38	0.38	0.37	164	1015587	296	41	233	22	268
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.51	228	1131314	245	27	191	27	228
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.68	0.67	0.69	305	1117819	160	25	111	24	153
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.33	0.33	0.34	151	1123806	312	48	245	19	310
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.71	0.70	0.71	320	1116316	158	22	107	29	138
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.35	0.34	0.36	153	1094035	290	40	232	18	292
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.61	0.59	0.64	268	1119334	184	21	133	30	184
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.56	0.56	0.56	249	1098461	218	30	163	25	197
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.19	0.18	0.19	74	945610	325	42	274	9	330
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.42	0.41	0.42	159	1201646	291	25	195	71	225
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.52	224	1137356	236	32	174	30	223
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.47	0.47	0.47	222	1117790	269	18	230	21	248
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.69	0.69	0.69	318	1135820	167	27	113	27	146
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.37	0.36	0.38	158	977489	271	43	211	17	276
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.65	0.61	0.69	304	1073402	166	18	121	27	191
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.54	0.52	0.56	253	1117806	233	20	181	32	238

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

2. Individual counts for CRWrnafold [ download as .csv ]