CompaRNA - on-line benchmarks of RNA structure prediction methods

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Overview

Metric	PETfold_pre2.0(seed)		CentroidAlifold(seed)
MCC	0.800	>	0.796
Average MCC ± 95% Confidence Intervals	0.802 ± 0.019	>	0.790 ± 0.032
Sensitivity	0.772	>	0.706
Positive Predictive Value	0.830	<	0.897
Total TP	23236	>	21223
Total TN	79084318	<	79088671
Total FP	7744	>	3503
Total FP CONTRA	877	>	450
Total FP INCONS	3896	>	1983
Total FP COMP	2971	>	1070
Total FN	6844	<	8857
P-value	4.48494289621e-08

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Performance plots

Comparison of performance of PETfold_pre2.0(seed) and CentroidAlifold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and CentroidAlifold(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and CentroidAlifold(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and CentroidAlifold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and CentroidAlifold(seed)).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP	23236
Total TN	79084318
Total FP	7744
Total FP CONTRA	877
Total FP INCONS	3896
Total FP COMP	2971
Total FN	6844

Total Scores
MCC	0.800
Average MCC ± 95% Confidence Intervals	0.802 ± 0.019
Sensitivity	0.772
Positive Predictive Value	0.830
Nr of predictions	64

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.89	0.88	0.90	405	1085153	80	10	33	37	53
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.80	0.78	0.83	369	1141870	113	17	60	36	105
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.85	0.84	0.87	395	1170759	96	18	43	35	75
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.86	0.86	0.87	390	1107367	95	16	43	36	66
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.85	0.83	0.87	392	1172293	95	17	44	34	81
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.86	388	1181504	96	16	45	35	88
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.86	0.86	0.87	394	1108851	94	17	43	34	63
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.86	0.84	0.88	392	1178434	98	11	43	44	73
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.85	0.84	0.86	387	1135829	97	15	47	35	76
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.85	0.82	0.87	392	1201573	98	16	44	38	84
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.85	0.83	0.87	385	1152477	92	16	43	33	81
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.86	386	1179969	96	16	45	35	85
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.86	0.84	0.88	393	1190749	97	11	43	43	75
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.80	0.79	0.81	353	1082222	118	17	64	37	92
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.86	386	1178430	105	17	47	41	87
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.83	0.81	0.86	384	1207786	102	15	50	37	91
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.87	392	1198473	97	16	45	36	86
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.86	0.86	0.87	388	1105880	95	18	42	35	65
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.83	0.80	0.86	388	1218691	98	16	46	36	96
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.87	391	1198474	97	16	45	36	87
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.85	0.82	0.87	386	1192295	93	16	43	34	82
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.87	0.86	0.87	391	1111838	94	15	42	37	64
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.83	0.82	0.85	378	1122307	105	14	52	39	84
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.86	0.85	0.86	380	1085161	98	14	46	38	66
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.86	0.85	0.87	390	1114823	98	15	43	40	67
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.84	0.83	0.85	377	1110354	101	16	48	37	76
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.85	369	1129823	106	15	49	42	81
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.85	0.83	0.86	385	1179970	103	16	45	42	79
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.84	0.83	0.85	377	1117815	109	16	52	41	76
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.85	0.84	0.87	388	1144894	97	16	43	38	76
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.78	0.77	0.80	331	1015610	118	18	66	34	101
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.83	0.82	0.84	372	1131319	111	16	53	42	84
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.85	377	1117816	104	17	50	37	81
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.82	0.80	0.84	382	1189200	109	16	55	38	94
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.74	0.72	0.77	332	1123817	133	22	79	32	129
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.68	0.66	0.70	305	1445417	186	15	113	58	157
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.65	0.62	0.68	300	1579311	211	15	127	69	182
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.68	0.65	0.71	322	1611455	199	13	120	66	174
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.60	0.54	0.66	286	2126521	223	18	128	77	248
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.67	0.64	0.71	318	1615053	200	15	117	68	178
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.64	0.61	0.67	303	1665770	223	20	132	71	192
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.86	0.85	0.87	391	1116315	99	14	45	40	67
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.87	0.84	0.89	376	1094037	99	6	41	52	69
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.87	0.84	0.89	381	1119327	104	6	42	56	71
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.87	0.86	0.89	382	1098473	103	6	42	55	64
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.65	0.62	0.68	297	1636709	218	15	124	79	184
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.83	0.80	0.87	357	1215610	110	5	48	57	89
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.79	0.76	0.81	309	945618	130	6	67	57	95
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.84	0.83	0.85	317	1201654	139	6	48	85	67
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.83	0.81	0.86	362	1137365	112	11	48	53	85
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.79	0.76	0.82	299	1152557	159	6	59	94	95
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.59	0.53	0.66	250	1401598	188	21	106	61	220
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.79	0.76	0.81	359	1117819	116	16	66	34	111
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.86	0.85	0.87	395	1135823	93	17	43	33	69
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.61	0.58	0.64	294	1606070	223	18	146	59	209
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.63	0.60	0.67	304	1593548	214	15	138	61	202
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.87	0.85	0.89	367	977489	81	8	37	36	67
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.79	0.73	0.86	361	1073423	107	9	52	46	134
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.76	0.68	0.86	364	1500354	120	9	51	60	171
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.75	0.67	0.85	365	1471040	119	5	60	54	182
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.76	0.67	0.86	376	1606090	108	8	54	46	186
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.77	0.70	0.86	376	1433534	108	3	58	47	164
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.80	0.73	0.86	387	1204680	102	10	51	41	140
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.80	0.75	0.86	368	1117832	112	8	52	52	123

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Performance of CentroidAlifold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

Total Base Pair Counts
Total TP	21223
Total TN	79088671
Total FP	3503
Total FP CONTRA	450
Total FP INCONS	1983
Total FP COMP	1070
Total FN	8857

Total Scores
MCC	0.796
Average MCC ± 95% Confidence Intervals	0.790 ± 0.032
Sensitivity	0.706
Positive Predictive Value	0.897
Nr of predictions	64

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2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.90	0.86	0.95	393	1085187	55	6	15	34	65
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.90	368	1141906	52	10	32	10	106
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	385	1170801	38	9	20	9	85
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	374	1107413	39	9	20	10	82
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.92	372	1172342	41	9	23	9	101
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.92	381	1181541	41	9	22	10	95
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	375	1108900	39	9	21	9	82
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.87	0.80	0.93	373	1178481	41	4	22	15	92
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.92	379	1135867	41	9	23	9	84
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	381	1201614	41	9	21	11	95
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	372	1152519	39	9	21	9	94
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	376	1180010	40	9	21	10	95
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.94	374	1190796	41	4	22	15	94
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	340	1082268	59	9	39	11	105
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.84	0.78	0.91	368	1178477	47	9	26	12	105
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	383	1207823	39	9	20	10	92
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	381	1198515	40	9	21	10	97
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	372	1105927	39	9	20	10	81
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.85	0.78	0.92	379	1218731	41	9	22	10	105
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.92	382	1198513	40	9	22	9	96
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.93	374	1192336	40	9	21	10	94
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	373	1111883	39	9	21	9	82
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.84	0.77	0.90	358	1122354	48	8	31	9	104
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.92	361	1085207	41	8	25	8	85
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.92	371	1114869	40	9	22	9	86
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.90	363	1110392	50	13	27	10	90
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.83	0.77	0.90	347	1129872	48	8	29	11	103
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.86	0.80	0.92	371	1180013	46	9	23	14	93
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.90	357	1117863	52	9	31	12	96
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.86	0.79	0.92	368	1144943	39	9	21	9	96
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.79	0.73	0.84	316	1015651	66	12	46	8	116
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.90	360	1131361	50	9	30	11	96
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	361	1117862	46	11	26	9	97
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.83	0.77	0.90	367	1189245	50	10	31	9	109
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.76	0.70	0.82	322	1123856	83	13	59	11	139
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.53	0.37	0.77	170	1445629	73	4	47	22	292
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.53	0.37	0.77	177	1579523	74	4	49	21	305
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.54	0.37	0.78	185	1611673	73	4	48	21	311
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.45	0.30	0.69	158	2126723	93	6	66	21	376
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.53	0.37	0.76	182	1615264	78	4	53	21	314
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.52	0.36	0.74	177	1665987	83	5	56	22	318
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.93	374	1116361	39	8	22	9	84
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	360	1094074	43	2	24	17	85
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	364	1119366	44	2	24	18	88
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.88	0.82	0.94	365	1098513	44	3	22	19	81
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.50	0.35	0.72	168	1636913	92	3	61	28	313
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.85	0.77	0.93	344	1215650	51	2	24	25	102
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.80	0.74	0.87	297	945660	69	2	41	26	107
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.90	303	1201687	92	4	31	57	81
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.92	353	1137401	53	5	27	21	94
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.81	0.74	0.88	291	1152590	94	3	37	54	103
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.45	0.30	0.67	141	1401765	92	7	62	23	329
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.89	358	1117856	57	12	34	11	112
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.93	377	1135871	39	9	21	9	87
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.48	0.33	0.70	167	1606289	89	4	68	17	336
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.52	0.35	0.77	179	1593773	71	4	49	18	327
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.86	0.81	0.92	351	977520	61	3	27	31	83
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.81	0.72	0.92	356	1073456	57	6	27	24	139
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.78	0.66	0.92	354	1500393	66	5	26	35	181
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.75	0.63	0.90	344	1471089	68	3	34	31	203
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.78	0.65	0.92	368	1606129	52	6	25	21	194
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.79	0.68	0.93	367	1433576	53	2	26	25	173
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.80	0.70	0.92	368	1204728	49	8	24	17	159
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.80	0.71	0.90	348	1117874	63	6	32	25	143

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

Performance of CentroidAlifold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

2. Individual counts for CentroidAlifold(seed) [ download as .csv ]