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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) Mastr(seed)
MCC 0.623 > 0.000
Average MCC ± 95% Confidence Intervals 0.624 ± 0.125 > 0.000 ± 0.000
Sensitivity 0.574 > 0.000
Positive Predictive Value 0.677 > 0.000
Total TP 841 > 0
Total TN 4973536 < 4974778
Total FP 597 > 0
Total FP CONTRA 54 > 0
Total FP INCONS 347 > 0
Total FP COMP 196 > 0
Total FN 625 < 1466
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Mastr(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Mastr(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Mastr(seed)).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 841
Total TN 4973536
Total FP 597
Total FP CONTRA 54
Total FP INCONS 347
Total FP COMP 196
Total FN 625
Total Scores
MCC 0.623
Average MCC ± 95% Confidence Intervals 0.624 ± 0.125
Sensitivity 0.574
Positive Predictive Value 0.677
Nr of predictions 3

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00306 0.68 0.66 0.70 305 1445417 186 15 113 58 157
CRW_00379 0.60 0.54 0.66 286 2126521 223 18 128 77 248
CRW_00800 0.59 0.53 0.66 250 1401598 188 21 106 61 220

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 0
Total TN 4974778
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 1466
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 3

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00306 0.00 0.00 0.00 0 1445850 0 0 0 0 462
CRW_00379 0.00 0.00 0.00 0 2126953 0 0 0 0 534
CRW_00800 0.00 0.00 0.00 0 1401975 0 0 0 0 470

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.