CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAalifold(20)		CRWrnafold
MCC	0.828	>	0.537
Average MCC ± 95% Confidence Intervals	0.828 ± 0.011	>	0.534 ± 0.052
Sensitivity	0.789	>	0.529
Positive Predictive Value	0.868	>	0.545
Total TP	8998	>	6032
Total TN	27682914	>	27682205
Total FP	1804	<	5577
Total FP CONTRA	272	<	666
Total FP INCONS	1093	<	4374
Total FP COMP	439	<	537
Total FN	2402	<	5368
P-value	5.02343278931e-08

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Performance plots

Comparison of performance of RNAalifold(20) and CRWrnafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(20) and CRWrnafold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(20) and CRWrnafold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(20) and CRWrnafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(20) and CRWrnafold).

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Performance of RNAalifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(20)

Total Base Pair Counts
Total TP	8998
Total TN	27682914
Total FP	1804
Total FP CONTRA	272
Total FP INCONS	1093
Total FP COMP	439
Total FN	2402

Total Scores
MCC	0.828
Average MCC ± 95% Confidence Intervals	0.828 ± 0.011
Sensitivity	0.789
Positive Predictive Value	0.868
Nr of predictions	25

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2. Individual counts for RNAalifold(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.87	372	1107390	68	12	42	14	84
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.86	0.83	0.89	381	1108875	61	12	37	12	76
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.87	380	1135841	71	13	44	14	83
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.77	0.75	0.80	332	1082242	94	12	70	12	113
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.86	0.83	0.89	378	1105903	56	14	33	9	75
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.85	0.83	0.88	376	1111859	66	12	39	15	79
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.82	0.79	0.87	363	1122332	69	11	45	13	99
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.87	360	1085185	68	13	43	12	86
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.87	368	1114849	68	12	42	14	89
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.82	0.79	0.85	359	1110374	76	14	48	14	94
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.86	349	1129851	72	10	46	16	101
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.87	360	1117845	71	12	43	16	93
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.85	363	1144916	75	12	50	13	101
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.89	363	1131350	62	12	35	15	93
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.88	364	1117844	66	13	39	14	94
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.86	373	1116333	74	11	48	15	85
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.91	361	1094062	61	7	30	24	84
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.89	358	1119354	70	6	38	26	94
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.87	0.83	0.91	368	1098500	61	9	26	26	78
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.78	0.74	0.83	298	945642	94	6	54	34	106
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.87	348	1137388	80	6	44	30	99
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.78	0.74	0.82	350	1117832	97	13	65	19	120
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	374	1135854	61	12	38	11	90
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.78	0.71	0.86	353	1073436	80	10	46	24	142
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.78	0.71	0.86	347	1117857	83	8	48	27	144

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Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

Total Base Pair Counts
Total TP	6032
Total TN	27682205
Total FP	5577
Total FP CONTRA	666
Total FP INCONS	4374
Total FP COMP	537
Total FN	5368

Total Scores
MCC	0.537
Average MCC ± 95% Confidence Intervals	0.534 ± 0.052
Sensitivity	0.529
Positive Predictive Value	0.545
Nr of predictions	25

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2. Individual counts for CRWrnafold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.57	0.56	0.57	257	1107367	210	22	170	18	199
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.57	0.57	0.58	259	1108856	209	20	170	19	198
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.48	226	1135811	256	30	211	15	237
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.38	0.38	0.39	168	1082220	282	31	237	14	277
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.53	0.53	0.54	240	1105883	225	26	179	20	213
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.50	225	1111832	246	27	202	17	230
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.69	0.67	0.71	311	1122312	152	21	107	24	151
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.41	0.41	0.41	181	1085155	279	39	226	14	265
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.65	0.65	0.66	296	1114820	177	28	127	22	161
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.44	0.43	0.44	196	1110351	263	35	213	15	257
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.42	182	1129824	270	20	230	20	268
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.67	0.66	0.68	299	1117818	160	18	125	17	154
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.60	0.59	0.61	274	1144893	197	27	147	23	190
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.51	228	1131314	245	27	191	27	228
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.68	0.67	0.69	305	1117819	160	25	111	24	153
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.71	0.70	0.71	320	1116316	158	22	107	29	138
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.35	0.34	0.36	153	1094035	290	40	232	18	292
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.61	0.59	0.64	268	1119334	184	21	133	30	184
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.56	0.56	0.56	249	1098461	218	30	163	25	197
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.19	0.18	0.19	74	945610	325	42	274	9	330
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.52	224	1137356	236	32	174	30	223
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.47	0.47	0.47	222	1117790	269	18	230	21	248
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.69	0.69	0.69	318	1135820	167	27	113	27	146
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.65	0.61	0.69	304	1073402	166	18	121	27	191
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.54	0.52	0.56	253	1117806	233	20	181	32	238

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAalifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(20)

2. Individual counts for RNAalifold(20) [ download as .csv ]

Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

2. Individual counts for CRWrnafold [ download as .csv ]