CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAalifold(20)		CentroidFold
MCC	0.678	>	0.492
Average MCC ± 95% Confidence Intervals	0.678 ± 0.044	>	0.493 ± 0.028
Sensitivity	0.625	>	0.430
Positive Predictive Value	0.736	>	0.563
Total TP	22762	>	15655
Total TN	102212571	<	102215715
Total FP	9731	<	14303
Total FP CONTRA	1486	<	1836
Total FP INCONS	6694	<	10307
Total FP COMP	1551	<	2160
Total FN	13668	<	20775
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNAalifold(20) and CentroidFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(20) and CentroidFold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(20) and CentroidFold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(20) and CentroidFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(20) and CentroidFold).

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Performance of RNAalifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(20)

Total Base Pair Counts
Total TP	22762
Total TN	102212571
Total FP	9731
Total FP CONTRA	1486
Total FP INCONS	6694
Total FP COMP	1551
Total FN	13668

Total Scores
MCC	0.678
Average MCC ± 95% Confidence Intervals	0.678 ± 0.044
Sensitivity	0.625
Positive Predictive Value	0.736
Nr of predictions	76

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2. Individual counts for RNAalifold(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.87	0.84	0.90	385	1085172	61	7	37	17	73
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.87	371	1141890	74	12	43	19	103
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.83	0.80	0.86	374	1170779	75	11	51	13	96
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.87	372	1107390	68	12	42	14	84
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.81	0.76	0.86	361	1172324	71	11	50	10	112
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.90	382	1181529	55	14	28	13	94
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.86	0.83	0.89	381	1108875	61	12	37	12	76
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.85	0.81	0.90	376	1178461	63	6	37	20	89
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.87	380	1135841	71	13	44	14	83
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.87	371	1201597	71	12	45	14	105
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.88	372	1152500	62	12	37	13	94
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.79	0.75	0.82	355	1179984	91	17	60	14	116
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.88	368	1190777	71	7	44	20	100
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.77	0.75	0.80	332	1082242	94	12	70	12	113
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.80	0.76	0.84	358	1178455	78	13	54	11	115
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.82	0.79	0.86	373	1207803	68	15	44	9	102
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.88	378	1198495	67	12	41	14	100
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.86	0.83	0.89	378	1105903	56	14	33	9	75
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.79	0.75	0.83	364	1218705	87	17	55	15	120
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	373	1198502	61	12	39	10	105
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.87	363	1192322	68	14	41	13	105
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.85	0.83	0.88	376	1111859	66	12	39	15	79
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.82	0.79	0.87	363	1122332	69	11	45	13	99
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.87	360	1085185	68	13	43	12	86
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.87	368	1114849	68	12	42	14	89
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.82	0.79	0.85	359	1110374	76	14	48	14	94
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.86	349	1129851	72	10	46	16	101
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.81	0.78	0.85	360	1179994	80	12	50	18	104
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.87	360	1117845	71	12	43	16	93
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.85	363	1144916	75	12	50	13	101
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.89	363	1131350	62	12	35	15	93
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.88	364	1117844	66	13	39	14	94
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.81	0.76	0.86	361	1189232	70	13	47	10	115
CRW_00298	SSU_rRNA_eukarya links to Rfam database...	0.43	0.38	0.49	187	1620517	224	43	153	28	307
CRW_00301	SSU_rRNA_eukarya links to Rfam database...	0.42	0.37	0.48	192	1762101	229	37	173	19	327
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.42	0.38	0.46	176	1445467	237	39	168	30	286
CRW_00310	SSU_rRNA_eukarya links to Rfam database...	0.46	0.39	0.55	204	1805579	190	29	138	23	317
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.41	0.35	0.47	178	1627730	219	36	166	17	324
CRW_00330	SSU_rRNA_eukarya links to Rfam database...	0.40	0.35	0.47	182	1988624	243	35	174	34	335
CRW_00332	SSU_rRNA_eukarya links to Rfam database...	0.39	0.34	0.43	164	1769642	239	35	180	24	313
CRW_00333	SSU_rRNA_eukarya links to Rfam database...	0.34	0.29	0.40	150	1892114	241	34	187	20	364
CRW_00345	SSU_rRNA_eukarya links to Rfam database...	0.43	0.38	0.48	189	1586477	222	39	166	17	309
CRW_00346	SSU_rRNA_eukarya links to Rfam database...	0.45	0.40	0.50	202	1584688	230	32	168	30	299
CRW_00348	SSU_rRNA_eukarya links to Rfam database...	0.43	0.38	0.48	190	1615106	228	41	166	21	313
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.43	0.38	0.49	192	1674972	227	34	167	26	315
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.39	0.34	0.45	166	1579381	248	30	176	42	316
CRW_00370	SSU_rRNA_eukarya links to Rfam database...	0.52	0.47	0.57	240	1640342	204	34	150	20	266
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.43	0.38	0.49	187	1611527	222	27	169	26	309
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.40	0.35	0.46	174	1625925	228	37	170	21	324
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.44	0.37	0.51	193	1750879	199	35	149	15	322
CRW_00403	SSU_rRNA_eukarya links to Rfam database...	0.39	0.37	0.42	170	1606127	272	38	193	41	294
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.43	0.39	0.48	191	1615105	227	43	164	20	305
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.38	0.35	0.41	171	1665811	266	36	207	23	324
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.86	373	1116333	74	11	48	15	85
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.91	361	1094062	61	7	30	24	84
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.89	358	1119354	70	6	38	26	94
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.87	0.83	0.91	368	1098500	61	9	26	26	78
CRW_00598	SSU_rRNA_eukarya links to Rfam database...	0.42	0.38	0.47	187	1665825	229	39	174	16	304
CRW_00758	SSU_rRNA_eukarya links to Rfam database...	0.48	0.43	0.53	210	1640373	205	34	149	22	273
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.42	0.38	0.48	182	1636762	232	39	162	31	299
CRW_00760	SSU_rRNA_eukarya links to Rfam database...	0.43	0.37	0.50	179	1638594	209	38	144	27	307
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.78	0.74	0.83	298	945642	94	6	54	34	106
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.87	348	1137388	80	6	44	30	99
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.74	0.70	0.79	276	1152572	131	10	63	58	118
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.78	0.74	0.82	350	1117832	97	13	65	19	120
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	374	1135854	61	12	38	11	90
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.47	0.42	0.53	210	1606133	216	27	158	31	293
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.44	0.38	0.50	193	1593619	210	32	161	17	313
CRW_01300	SSU_rRNA_eukarya links to Rfam database...	0.52	0.45	0.59	231	1693331	174	31	127	16	284
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.78	0.71	0.86	353	1073436	80	10	46	24	142
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.75	0.65	0.86	347	1500373	97	7	51	39	188
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.73	0.62	0.86	341	1471072	93	2	55	36	206
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.75	0.65	0.87	364	1606111	77	8	45	24	198
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.76	0.67	0.87	360	1433555	85	3	53	29	180
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.72	0.65	0.80	341	1204702	101	13	72	16	186
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.78	0.71	0.86	347	1117857	83	8	48	27	144

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Performance of CentroidFold - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidFold

Total Base Pair Counts
Total TP	15655
Total TN	102215715
Total FP	14303
Total FP CONTRA	1836
Total FP INCONS	10307
Total FP COMP	2160
Total FN	20775

Total Scores
MCC	0.492
Average MCC ± 95% Confidence Intervals	0.493 ± 0.028
Sensitivity	0.430
Positive Predictive Value	0.563
Nr of predictions	76

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2. Individual counts for CentroidFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.79	0.76	0.83	347	1085183	108	8	63	37	111
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.68	0.66	0.71	312	1141875	159	19	110	30	162
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.60	0.49	0.75	230	1170907	91	8	70	13	240
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.56	0.49	0.64	223	1107466	140	16	111	13	233
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.60	0.51	0.71	241	1172408	111	9	88	14	232
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.64	0.57	0.72	269	1181581	110	23	80	7	207
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.55	0.49	0.63	225	1108945	147	19	116	12	232
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.56	0.49	0.63	228	1178519	155	15	118	22	237
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.59	0.49	0.70	226	1135957	106	11	84	11	237
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.63	0.56	0.70	268	1201642	136	16	99	21	208
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.55	0.47	0.66	217	1152591	126	17	96	13	249
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.51	0.42	0.62	200	1180095	129	14	107	8	271
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.61	0.53	0.70	247	1190845	120	6	98	16	221
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.35	0.31	0.39	139	1082299	226	23	195	8	306
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.52	0.45	0.59	213	1178522	162	17	128	17	260
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.59	0.52	0.67	247	1207869	131	18	101	12	228
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.59	0.52	0.67	250	1198552	140	19	105	16	228
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.56	0.49	0.65	221	1105989	128	13	105	10	232
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.66	0.61	0.71	296	1218724	154	20	101	33	188
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.57	0.50	0.66	237	1198568	130	20	101	9	241
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.45	0.35	0.57	165	1192449	145	20	106	19	303
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.67	0.57	0.79	260	1111955	83	11	60	12	195
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.48	0.41	0.55	190	1122405	171	26	130	15	272
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.51	0.43	0.60	194	1085280	142	14	113	15	252
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.70	249	1114913	130	13	96	21	208
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.48	0.36	0.64	165	1110536	105	15	79	11	288
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.49	0.41	0.57	186	1129931	157	13	126	18	264
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.54	0.45	0.64	209	1180088	132	19	100	13	255
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.53	0.42	0.67	192	1117973	105	9	86	10	261
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.62	0.57	0.68	265	1144950	146	18	108	20	199
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.48	0.36	0.65	162	1131511	101	11	76	14	294
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.67	0.59	0.76	268	1117909	98	16	67	15	190
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.61	0.55	0.68	260	1189270	143	18	105	20	216
CRW_00298	SSU_rRNA_eukarya links to Rfam database...	0.25	0.22	0.28	109	1620517	295	50	224	21	385
CRW_00301	SSU_rRNA_eukarya links to Rfam database...	0.48	0.39	0.58	203	1762152	211	28	120	63	316
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.29	0.26	0.32	120	1445480	309	50	200	59	342
CRW_00310	SSU_rRNA_eukarya links to Rfam database...	0.38	0.34	0.42	178	1805524	303	44	204	55	343
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.57	0.48	0.67	240	1627752	163	19	99	45	262
CRW_00330	SSU_rRNA_eukarya links to Rfam database...	0.30	0.25	0.36	131	1988654	302	33	197	72	386
CRW_00332	SSU_rRNA_eukarya links to Rfam database...	0.25	0.22	0.28	104	1769656	299	47	214	38	373
CRW_00333	SSU_rRNA_eukarya links to Rfam database...	0.30	0.24	0.36	125	1892139	288	29	192	67	389
CRW_00345	SSU_rRNA_eukarya links to Rfam database...	0.41	0.37	0.45	186	1586456	267	40	189	38	312
CRW_00346	SSU_rRNA_eukarya links to Rfam database...	0.40	0.38	0.42	189	1584645	289	48	208	33	312
CRW_00348	SSU_rRNA_eukarya links to Rfam database...	0.37	0.31	0.44	157	1615148	235	27	171	37	346
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.42	0.39	0.45	200	1674917	285	39	209	37	307
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.34	0.31	0.38	150	1579355	289	44	204	41	332
CRW_00370	SSU_rRNA_eukarya links to Rfam database...	0.38	0.33	0.43	167	1640375	256	43	181	32	339
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.47	0.39	0.56	194	1611562	196	29	125	42	302
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.48	0.41	0.58	202	1625955	204	26	123	55	296
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.32	0.30	0.34	156	1750800	337	47	253	37	359
CRW_00403	SSU_rRNA_eukarya links to Rfam database...	0.31	0.29	0.34	135	1606132	324	52	209	63	329
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.42	0.35	0.49	173	1615153	226	27	150	49	323
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.42	0.36	0.48	180	1665851	239	34	160	45	315
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.71	0.64	0.79	292	1116394	100	14	65	21	166
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.34	0.28	0.42	125	1094162	188	16	157	15	320
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.37	0.32	0.43	143	1119420	207	36	157	14	309
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.65	0.59	0.72	261	1098541	124	19	82	23	185
CRW_00598	SSU_rRNA_eukarya links to Rfam database...	0.40	0.37	0.45	180	1665823	270	42	180	48	311
CRW_00758	SSU_rRNA_eukarya links to Rfam database...	0.37	0.34	0.40	164	1640353	298	41	208	49	319
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.34	0.28	0.42	134	1636828	232	34	149	49	347
CRW_00760	SSU_rRNA_eukarya links to Rfam database...	0.38	0.34	0.42	167	1638559	278	50	179	49	319
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.38	0.30	0.50	120	945758	137	16	106	15	284
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.51	0.40	0.65	179	1137510	120	5	92	23	268
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.35	0.28	0.44	110	1152672	173	15	124	34	284
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.59	0.56	0.62	265	1117830	190	14	151	25	205
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	256	1135921	119	15	86	18	208
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.41	0.37	0.45	185	1606114	268	39	190	39	318
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.46	0.41	0.52	206	1593608	228	40	151	37	300
CRW_01300	SSU_rRNA_eukarya links to Rfam database...	0.41	0.37	0.45	192	1693289	291	56	183	52	323
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.55	0.49	0.61	244	1073448	180	13	140	27	251
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.53	0.49	0.57	264	1500316	234	15	183	36	271
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.46	0.39	0.55	215	1471076	203	25	154	24	332
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.57	0.53	0.61	297	1606045	214	20	166	28	265
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.62	0.57	0.68	307	1433517	177	8	139	30	233
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.49	0.42	0.59	220	1204752	177	19	137	21	307
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.51	0.47	0.56	229	1117849	211	14	168	29	262

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAalifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(20)

2. Individual counts for RNAalifold(20) [ download as .csv ]

Performance of CentroidFold - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidFold

2. Individual counts for CentroidFold [ download as .csv ]