CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

Home

Methods

Datasets

Rankings

RNA 2D Atlas

Help

FAQ

Contact us

RSS feeds

Twitter

Overview

Metric	RNAalifold(seed)		Afold
MCC	0.746	>	0.436
Average MCC ± 95% Confidence Intervals	0.744 ± 0.040	>	0.437 ± 0.032
Sensitivity	0.679	>	0.432
Positive Predictive Value	0.819	>	0.442
Total TP	20846	>	13261
Total TN	82043479	>	82038885
Total FP	5574	<	18731
Total FP CONTRA	1046	<	2435
Total FP INCONS	3549	<	14339
Total FP COMP	979	<	1957
Total FN	9856	<	17441
P-value	3.56938820447e-08

^top

Performance plots

Comparison of performance of RNAalifold(seed) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and Afold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(seed) and Afold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and Afold).

^top

Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP	20846
Total TN	82043479
Total FP	5574
Total FP CONTRA	1046
Total FP INCONS	3549
Total FP COMP	979
Total FN	9856

Total Scores
MCC	0.746
Average MCC ± 95% Confidence Intervals	0.744 ± 0.040
Sensitivity	0.679
Positive Predictive Value	0.819
Nr of predictions	65

^top

2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.87	0.84	0.90	385	1085175	58	7	34	17	73
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.88	372	1170793	59	16	34	9	98
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	369	1107397	60	16	34	10	87
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.88	367	1172327	61	16	36	9	106
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.88	367	1181535	61	16	35	10	109
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.85	0.81	0.88	370	1108886	58	15	34	9	87
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.89	368	1178465	61	12	35	14	97
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.87	367	1135858	62	16	37	9	96
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	369	1201606	61	16	34	11	107
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	368	1152515	47	13	25	9	98
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	372	1180006	46	13	25	8	99
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	365	1190782	64	12	37	15	103
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.79	0.76	0.84	336	1082254	76	16	50	10	109
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.87	364	1178460	66	16	40	10	109
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.87	365	1207815	63	16	39	8	110
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.83	0.77	0.88	369	1198508	59	15	34	10	109
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	366	1105912	60	16	34	10	87
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	369	1218720	61	16	36	9	115
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.88	369	1198505	61	16	36	9	109
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	369	1192333	48	13	25	10	99
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	368	1111868	59	15	35	9	87
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.90	359	1122350	51	13	29	9	103
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.87	358	1085191	60	16	36	8	88
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.88	366	1114854	59	16	35	8	91
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.87	359	1110382	64	17	37	10	94
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	349	1129861	58	13	33	12	101
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.91	372	1180005	54	13	26	15	92
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.89	363	1117851	59	13	33	13	90
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.91	372	1144932	48	13	24	11	92
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.80	0.75	0.85	323	1015644	67	14	44	9	109
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.89	356	1131358	59	13	33	13	100
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.86	356	1117847	66	17	40	9	102
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.80	0.75	0.86	358	1189235	67	16	44	7	118
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.77	0.71	0.84	329	1123856	76	14	51	11	132
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.44	0.37	0.53	184	1627762	174	32	132	10	318
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.44	0.36	0.53	184	1675017	173	32	132	9	323
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.42	0.36	0.51	172	1579413	180	32	136	12	310
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.44	0.36	0.52	181	1611565	175	31	133	11	315
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.44	0.37	0.53	184	1625958	174	32	132	10	314
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.40	0.32	0.50	169	2126616	180	32	136	12	365
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.44	0.35	0.55	182	1750923	164	28	123	13	333
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.45	0.38	0.55	186	1615165	163	28	124	11	310
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.45	0.37	0.54	182	1665890	171	28	125	18	313
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.86	0.82	0.91	377	1116350	49	12	26	11	81
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.92	361	1094068	53	6	25	22	84
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.92	366	1119360	52	6	24	22	86
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.92	365	1098507	56	8	23	25	81
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.41	0.34	0.49	163	1636811	183	35	136	12	318
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.85	0.78	0.92	348	1215641	59	6	25	28	98
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.81	0.75	0.88	302	945656	72	5	37	30	102
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.91	312	1201683	85	4	26	55	72
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	355	1137395	59	8	28	23	92
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.78	0.73	0.84	288	1152577	109	10	46	53	106
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.42	0.33	0.52	156	1401675	160	25	119	16	314
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	356	1117856	63	14	34	15	114
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.41	0.34	0.49	172	1606179	193	36	141	16	331
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.43	0.36	0.52	181	1593657	177	34	133	10	325
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.83	0.79	0.88	344	977508	71	5	44	22	90
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.78	0.69	0.87	344	1073448	73	7	46	20	151
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.74	0.64	0.87	342	1500383	85	10	43	32	193
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.73	0.63	0.86	342	1471073	85	8	47	30	205
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.74	0.63	0.87	355	1606120	72	10	43	19	207
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.76	0.66	0.88	355	1433566	72	7	43	22	185
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.77	0.68	0.87	358	1204715	73	7	48	18	169
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.78	0.70	0.86	346	1117856	80	13	45	22	145

^top

Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP	13261
Total TN	82038885
Total FP	18731
Total FP CONTRA	2435
Total FP INCONS	14339
Total FP COMP	1957
Total FN	17441

Total Scores
MCC	0.436
Average MCC ± 95% Confidence Intervals	0.437 ± 0.032
Sensitivity	0.432
Positive Predictive Value	0.442
Nr of predictions	65

^top

2. Individual counts for Afold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.78	0.77	0.79	351	1085158	132	17	75	40	107
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.50	228	1170758	252	20	209	23	242
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.46	0.46	0.46	208	1107368	260	31	209	20	248
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.52	0.51	0.53	240	1172289	233	26	191	16	233
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.55	0.54	0.55	259	1181483	231	27	184	20	217
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.50	226	1108849	247	24	206	17	231
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.46	0.46	0.47	214	1178420	264	32	214	18	251
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.64	0.63	0.64	291	1135826	182	20	141	21	172
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.60	274	1201566	212	26	159	27	202
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.42	0.41	0.42	193	1152465	282	35	228	19	273
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.64	0.62	0.65	293	1179965	180	30	128	22	178
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.54	0.53	0.55	248	1190745	226	28	175	23	220
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.29	0.29	0.29	127	1082216	323	37	276	10	318
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.44	0.43	0.45	203	1178433	259	22	222	15	270
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.47	0.46	0.48	220	1207772	267	24	219	24	255
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.57	0.56	0.58	266	1198467	216	21	172	23	212
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.38	0.38	0.38	172	1105880	289	44	232	13	281
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.57	0.57	0.58	274	1218666	234	21	180	33	210
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.44	0.44	0.45	210	1198459	274	34	223	17	268
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.42	188	1192291	278	39	222	17	280
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.44	0.43	0.45	196	1111850	260	40	200	20	259
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.51	231	1122302	237	43	175	19	231
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.60	258	1085174	195	26	143	26	188
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.47	0.47	0.48	213	1114826	258	28	204	26	244
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.38	0.38	0.38	172	1110338	300	45	240	15	281
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.42	180	1129825	274	33	218	23	270
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.51	0.49	0.53	229	1179985	227	29	173	25	235
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.51	227	1117817	231	28	188	15	226
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.30	0.30	0.29	138	1144872	347	41	290	16	326
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.28	0.27	0.29	118	1015612	321	39	256	26	314
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.28	0.27	0.28	124	1131316	337	30	290	17	332
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.72	0.71	0.74	325	1117819	142	23	93	26	133
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.46	0.45	0.48	214	1189204	258	34	201	23	262
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.31	0.30	0.32	138	1123814	315	46	252	17	323
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.41	0.41	0.42	204	1627621	339	47	238	54	298
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.36	0.36	0.35	183	1674845	391	61	276	54	324
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.35	0.36	0.33	174	1579230	395	88	261	46	308
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.29	0.29	0.28	145	1611389	409	77	299	33	351
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.36	0.36	0.35	181	1625787	378	59	279	40	317
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.42	0.43	0.41	227	2126401	423	55	270	98	307
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.24	0.25	0.23	129	1750683	478	83	361	34	386
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.34	0.34	0.34	169	1615006	381	62	266	53	327
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.27	0.28	0.26	140	1665694	436	77	314	45	355
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.60	0.59	0.62	268	1116330	196	21	146	29	190
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.18	0.18	0.18	78	1094024	374	34	324	16	367
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.36	0.36	0.37	161	1119326	290	30	239	21	291
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.57	0.56	0.59	251	1098476	205	23	153	29	195
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.22	0.22	0.21	107	1636633	462	78	327	57	374
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.38	0.37	0.40	165	1215603	304	24	228	52	281
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.26	0.25	0.26	103	945610	313	37	250	26	301
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.30	0.29	0.32	113	1201668	314	34	210	70	271
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.36	0.36	0.36	160	1137342	302	44	240	18	287
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.21	0.22	0.21	85	1152511	379	51	274	54	309
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.55	0.53	0.57	251	1401532	269	24	168	77	219
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.49	227	1117798	259	23	212	24	243
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.32	0.32	0.32	160	1606024	390	54	290	46	343
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.32	0.33	0.31	167	1593473	402	81	284	37	339
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.37	0.37	0.37	160	977470	284	42	229	13	274
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.53	0.50	0.56	246	1073408	220	17	174	29	249
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.55	0.53	0.56	284	1500271	276	22	201	53	251
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.36	0.35	0.37	191	1470959	352	45	275	32	356
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.56	0.54	0.58	306	1605999	254	32	191	31	256
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.60	0.58	0.63	313	1433471	221	15	172	34	227
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.46	0.43	0.49	228	1204659	250	31	210	9	299
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.51	0.48	0.53	237	1117812	242	21	190	31	254

^top

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

2. Individual counts for RNAalifold(seed) [ download as .csv ]

Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

2. Individual counts for Afold [ download as .csv ]