CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAalifold(seed)		Fold
MCC	0.744	>	0.406
Average MCC ± 95% Confidence Intervals	0.742 ± 0.039	>	0.406 ± 0.026
Sensitivity	0.678	>	0.408
Positive Predictive Value	0.818	>	0.404
Total TP	21759	>	13096
Total TN	85766748	>	85760987
Total FP	5870	<	21279
Total FP CONTRA	1107	<	2788
Total FP INCONS	3750	<	16493
Total FP COMP	1013	<	1998
Total FN	10343	<	19006
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNAalifold(seed) and Fold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and Fold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(seed) and Fold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and Fold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and Fold).

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Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP	21759
Total TN	85766748
Total FP	5870
Total FP CONTRA	1107
Total FP INCONS	3750
Total FP COMP	1013
Total FN	10343

Total Scores
MCC	0.744
Average MCC ± 95% Confidence Intervals	0.742 ± 0.039
Sensitivity	0.678
Positive Predictive Value	0.818
Nr of predictions	68

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.87	0.84	0.90	385	1085175	58	7	34	17	73
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.88	363	1141905	62	14	34	14	111
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.88	372	1170793	59	16	34	9	98
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	369	1107397	60	16	34	10	87
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.88	367	1172327	61	16	36	9	106
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.88	367	1181535	61	16	35	10	109
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.85	0.81	0.88	370	1108886	58	15	34	9	87
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.89	368	1178465	61	12	35	14	97
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.87	367	1135858	62	16	37	9	96
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	369	1201606	61	16	34	11	107
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	368	1152515	47	13	25	9	98
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	372	1180006	46	13	25	8	99
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	365	1190782	64	12	37	15	103
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.79	0.76	0.84	336	1082254	76	16	50	10	109
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.87	364	1178460	66	16	40	10	109
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.87	365	1207815	63	16	39	8	110
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.83	0.77	0.88	369	1198508	59	15	34	10	109
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	366	1105912	60	16	34	10	87
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	369	1218720	61	16	36	9	115
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.88	369	1198505	61	16	36	9	109
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	369	1192333	48	13	25	10	99
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	368	1111868	59	15	35	9	87
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.90	359	1122350	51	13	29	9	103
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.87	358	1085191	60	16	36	8	88
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.88	366	1114854	59	16	35	8	91
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.87	359	1110382	64	17	37	10	94
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	349	1129861	58	13	33	12	101
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.91	372	1180005	54	13	26	15	92
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.89	363	1117851	59	13	33	13	90
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.91	372	1144932	48	13	24	11	92
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.80	0.75	0.85	323	1015644	67	14	44	9	109
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.89	356	1131358	59	13	33	13	100
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.86	356	1117847	66	17	40	9	102
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.80	0.75	0.86	358	1189235	67	16	44	7	118
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.77	0.71	0.84	329	1123856	76	14	51	11	132
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.45	0.39	0.52	178	1445508	175	32	132	11	284
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.44	0.37	0.53	184	1627762	174	32	132	10	318
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.44	0.36	0.53	184	1675017	173	32	132	9	323
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.42	0.36	0.51	172	1579413	180	32	136	12	310
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.44	0.36	0.52	181	1611565	175	31	133	11	315
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.44	0.37	0.53	184	1625958	174	32	132	10	314
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.40	0.32	0.50	169	2126616	180	32	136	12	365
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.44	0.35	0.55	182	1750923	164	28	123	13	333
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.45	0.38	0.55	186	1615165	163	28	124	11	310
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.45	0.37	0.54	182	1665890	171	28	125	18	313
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.86	0.82	0.91	377	1116350	49	12	26	11	81
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.92	361	1094068	53	6	25	22	84
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.92	366	1119360	52	6	24	22	86
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.92	365	1098507	56	8	23	25	81
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.41	0.34	0.49	163	1636811	183	35	136	12	318
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.85	0.78	0.92	348	1215641	59	6	25	28	98
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.81	0.75	0.88	302	945656	72	5	37	30	102
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.91	312	1201683	85	4	26	55	72
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	355	1137395	59	8	28	23	92
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.78	0.73	0.84	288	1152577	109	10	46	53	106
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.42	0.33	0.52	156	1401675	160	25	119	16	314
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	356	1117856	63	14	34	15	114
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.88	372	1135856	59	15	35	9	92
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.41	0.34	0.49	172	1606179	193	36	141	16	331
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.43	0.36	0.52	181	1593657	177	34	133	10	325
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.83	0.79	0.88	344	977508	71	5	44	22	90
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.78	0.69	0.87	344	1073448	73	7	46	20	151
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.74	0.64	0.87	342	1500383	85	10	43	32	193
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.73	0.63	0.86	342	1471073	85	8	47	30	205
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.74	0.63	0.87	355	1606120	72	10	43	19	207
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.76	0.66	0.88	355	1433566	72	7	43	22	185
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.77	0.68	0.87	358	1204715	73	7	48	18	169
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.78	0.70	0.86	346	1117856	80	13	45	22	145

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Performance of Fold - scored lower in this pairwise comparison

1. Total counts & total scores for Fold

Total Base Pair Counts
Total TP	13096
Total TN	85760987
Total FP	21279
Total FP CONTRA	2788
Total FP INCONS	16493
Total FP COMP	1998
Total FN	19006

Total Scores
MCC	0.406
Average MCC ± 95% Confidence Intervals	0.406 ± 0.026
Sensitivity	0.408
Positive Predictive Value	0.404
Nr of predictions	68

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2. Individual counts for Fold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.56	0.57	0.56	259	1085140	238	22	180	36	199
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.62	0.63	0.61	299	1141829	219	35	153	31	175
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.51	0.51	0.52	239	1170753	241	24	199	18	231
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.40	0.41	0.40	185	1107355	286	30	246	10	271
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.44	0.44	0.44	207	1172278	279	31	230	18	266
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.54	0.54	0.54	259	1181475	236	33	186	17	217
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.43	0.43	0.43	198	1108845	279	32	230	17	259
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.42	0.43	0.42	200	1178403	299	28	249	22	265
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.38	0.38	0.38	176	1135818	299	27	257	15	287
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.53	0.53	0.54	253	1201553	246	34	185	27	223
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.45	0.44	0.45	204	1152472	262	26	219	17	262
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.53	0.52	0.54	246	1179962	231	33	175	23	225
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.40	0.40	0.39	188	1190720	309	32	256	21	280
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.28	0.28	0.28	125	1082214	333	31	286	16	320
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.50	226	1178426	251	26	202	23	247
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.45	0.46	0.44	219	1207740	296	42	234	20	256
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.53	0.52	0.54	247	1198465	241	32	182	27	231
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.37	0.37	0.37	167	1105882	297	32	247	18	286
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.48	238	1218645	286	36	222	28	246
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.37	0.38	0.37	181	1198432	321	48	265	8	297
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.39	0.39	0.40	183	1192281	294	41	235	18	285
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.54	0.54	0.54	245	1111832	232	27	182	23	210
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.36	0.36	0.37	168	1122293	309	37	253	19	294
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.52	0.52	0.52	233	1085151	238	41	176	21	213
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.59	0.59	0.59	271	1114809	212	28	163	21	186
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.32	0.32	0.32	144	1110348	313	38	265	10	309
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.36	0.35	0.37	159	1129828	293	31	238	24	291
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.58	0.56	0.59	262	1179969	207	27	158	22	202
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.33	0.33	0.32	151	1117794	327	43	272	12	302
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.53	0.52	0.53	243	1144885	238	27	186	25	221
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.32	0.32	0.33	140	1015595	312	49	241	22	292
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.29	0.29	0.29	130	1131315	331	40	275	16	326
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.48	0.49	0.48	225	1117789	265	38	208	19	233
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.52	237	1189193	251	38	185	28	239
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.41	0.39	0.42	181	1123819	271	41	209	21	280
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.09	0.09	0.08	43	1445337	532	80	390	62	419
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.40	0.40	0.39	203	1627589	370	67	251	52	299
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.36	0.37	0.35	186	1674831	392	68	280	44	321
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.27	0.29	0.25	138	1579211	437	87	317	33	344
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.34	0.35	0.33	173	1611383	414	61	293	60	323
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.26	0.28	0.25	137	1625762	453	84	323	46	361
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.44	0.45	0.44	241	2126401	411	60	251	100	293
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.29	0.30	0.28	155	1750699	443	74	328	41	360
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.35	0.36	0.34	177	1614982	392	60	284	48	319
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.29	0.31	0.28	152	1665688	448	68	317	63	343
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.57	0.56	0.57	257	1116315	221	28	165	28	201
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.30	0.30	0.31	133	1094029	317	35	263	19	312
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.42	0.42	0.42	191	1119306	279	34	225	20	261
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.50	0.50	0.50	222	1098458	256	20	203	33	224
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.31	0.32	0.29	156	1636612	443	67	310	66	325
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.20	0.20	0.20	90	1215568	391	45	317	29	356
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.25	0.25	0.25	100	945594	319	37	269	13	304
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.27	0.28	0.26	107	1201617	345	45	256	44	277
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.39	0.38	0.39	172	1137342	303	31	241	31	275
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.32	0.33	0.30	130	1152494	342	43	254	45	264
CRW_00800	SSU_rRNA_eukarya links to Rfam database...	0.52	0.52	0.52	243	1401506	300	34	192	74	227
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.53	0.53	0.52	250	1117779	255	29	202	24	220
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.37	0.38	0.37	175	1135806	315	41	256	18	289
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.36	0.37	0.35	187	1605990	391	60	291	40	316
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.28	0.28	0.27	143	1593476	430	75	311	44	363
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.37	0.36	0.38	158	977486	272	36	221	15	276
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.48	0.46	0.50	229	1073385	256	28	203	25	266
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.46	0.46	0.46	246	1500244	334	36	252	46	289
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.34	0.33	0.34	180	1470946	368	36	308	24	367
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.44	0.44	0.44	245	1605966	343	42	275	26	317
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.46	0.45	0.47	245	1433450	306	32	244	30	295
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.31	0.30	0.33	158	1204643	339	37	290	12	369
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.38	0.38	0.39	186	1117784	320	28	262	30	305

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

2. Individual counts for RNAalifold(seed) [ download as .csv ]

Performance of Fold - scored lower in this pairwise comparison

1. Total counts & total scores for Fold

2. Individual counts for Fold [ download as .csv ]