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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAalifold(seed) - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAalifold(seed) & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric RNAalifold(seed) Mastr(seed)
MCC 0.420 > 0.000
Average MCC ± 95% Confidence Intervals 0.420 ± 0.062 > 0.000 ± 0.000
Sensitivity 0.343 > 0.000
Positive Predictive Value 0.514 > 0.000
Total TP 503 > 0
Total TN 4973799 < 4974778
Total FP 515 > 0
Total FP CONTRA 89 > 0
Total FP INCONS 387 > 0
Total FP COMP 39 > 0
Total FN 963 < 1466
P-value 0.0

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Performance plots


  1. Comparison of performance of RNAalifold(seed) and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and Mastr(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(seed) and Mastr(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and Mastr(seed)).

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Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP 503
Total TN 4973799
Total FP 515
Total FP CONTRA 89
Total FP INCONS 387
Total FP COMP 39
Total FN 963
Total Scores
MCC 0.420
Average MCC ± 95% Confidence Intervals 0.420 ± 0.062
Sensitivity 0.343
Positive Predictive Value 0.514
Nr of predictions 3

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00306 0.45 0.39 0.52 178 1445508 175 32 132 11 284
CRW_00379 0.40 0.32 0.50 169 2126616 180 32 136 12 365
CRW_00800 0.42 0.33 0.52 156 1401675 160 25 119 16 314

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 0
Total TN 4974778
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 1466
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 3

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00306 0.00 0.00 0.00 0 1445850 0 0 0 0 462
CRW_00379 0.00 0.00 0.00 0 2126953 0 0 0 0 534
CRW_00800 0.00 0.00 0.00 0 1401975 0 0 0 0 470

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.