CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAalifold(seed)		RNAalifold(20)
MCC	0.743	>	0.732
Average MCC ± 95% Confidence Intervals	0.741 ± 0.041	>	0.733 ± 0.042
Sensitivity	0.677	<	0.681
Positive Predictive Value	0.817	>	0.788
Total TP	19947	<	20064
Total TN	78830741	>	78829705
Total FP	5352	<	6620
Total FP CONTRA	1039	>	978
Total FP INCONS	3441	<	4421
Total FP COMP	872	<	1221
Total FN	9528	>	9411
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNAalifold(seed) and RNAalifold(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and RNAalifold(20)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(seed) and RNAalifold(20)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and RNAalifold(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and RNAalifold(20)).

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Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP	19947
Total TN	78830741
Total FP	5352
Total FP CONTRA	1039
Total FP INCONS	3441
Total FP COMP	872
Total FN	9528

Total Scores
MCC	0.743
Average MCC ± 95% Confidence Intervals	0.741 ± 0.041
Sensitivity	0.677
Positive Predictive Value	0.817
Nr of predictions	62

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.87	0.84	0.90	385	1085175	58	7	34	17	73
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.88	363	1141905	62	14	34	14	111
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.88	372	1170793	59	16	34	9	98
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	369	1107397	60	16	34	10	87
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.88	367	1172327	61	16	36	9	106
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.88	367	1181535	61	16	35	10	109
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.85	0.81	0.88	370	1108886	58	15	34	9	87
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.89	368	1178465	61	12	35	14	97
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.87	367	1135858	62	16	37	9	96
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	369	1201606	61	16	34	11	107
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	368	1152515	47	13	25	9	98
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	372	1180006	46	13	25	8	99
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	365	1190782	64	12	37	15	103
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.79	0.76	0.84	336	1082254	76	16	50	10	109
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.87	364	1178460	66	16	40	10	109
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.87	365	1207815	63	16	39	8	110
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.83	0.77	0.88	369	1198508	59	15	34	10	109
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	366	1105912	60	16	34	10	87
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	369	1218720	61	16	36	9	115
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.82	0.77	0.88	369	1198505	61	16	36	9	109
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	369	1192333	48	13	25	10	99
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	368	1111868	59	15	35	9	87
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.90	359	1122350	51	13	29	9	103
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.87	358	1085191	60	16	36	8	88
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.88	366	1114854	59	16	35	8	91
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.87	359	1110382	64	17	37	10	94
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	349	1129861	58	13	33	12	101
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.91	372	1180005	54	13	26	15	92
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.89	363	1117851	59	13	33	13	90
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.91	372	1144932	48	13	24	11	92
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.89	356	1131358	59	13	33	13	100
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.86	356	1117847	66	17	40	9	102
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.80	0.75	0.86	358	1189235	67	16	44	7	118
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.45	0.39	0.52	178	1445508	175	32	132	11	284
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.44	0.37	0.53	184	1627762	174	32	132	10	318
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.44	0.36	0.53	184	1675017	173	32	132	9	323
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.42	0.36	0.51	172	1579413	180	32	136	12	310
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.44	0.36	0.52	181	1611565	175	31	133	11	315
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.44	0.37	0.53	184	1625958	174	32	132	10	314
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.40	0.32	0.50	169	2126616	180	32	136	12	365
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.44	0.35	0.55	182	1750923	164	28	123	13	333
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.45	0.38	0.55	186	1615165	163	28	124	11	310
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.45	0.37	0.54	182	1665890	171	28	125	18	313
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.86	0.82	0.91	377	1116350	49	12	26	11	81
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.92	361	1094068	53	6	25	22	84
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.87	0.81	0.92	366	1119360	52	6	24	22	86
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.87	0.82	0.92	365	1098507	56	8	23	25	81
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.41	0.34	0.49	163	1636811	183	35	136	12	318
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.81	0.75	0.88	302	945656	72	5	37	30	102
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.85	0.79	0.91	355	1137395	59	8	28	23	92
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.78	0.73	0.84	288	1152577	109	10	46	53	106
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.82	0.76	0.88	356	1117856	63	14	34	15	114
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.88	372	1135856	59	15	35	9	92
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.41	0.34	0.49	172	1606179	193	36	141	16	331
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.43	0.36	0.52	181	1593657	177	34	133	10	325
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.78	0.69	0.87	344	1073448	73	7	46	20	151
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.74	0.64	0.87	342	1500383	85	10	43	32	193
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.73	0.63	0.86	342	1471073	85	8	47	30	205
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.74	0.63	0.87	355	1606120	72	10	43	19	207
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.76	0.66	0.88	355	1433566	72	7	43	22	185
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.77	0.68	0.87	358	1204715	73	7	48	18	169
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.78	0.70	0.86	346	1117856	80	13	45	22	145

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Performance of RNAalifold(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNAalifold(20)

Total Base Pair Counts
Total TP	20064
Total TN	78829705
Total FP	6620
Total FP CONTRA	978
Total FP INCONS	4421
Total FP COMP	1221
Total FN	9411

Total Scores
MCC	0.732
Average MCC ± 95% Confidence Intervals	0.733 ± 0.042
Sensitivity	0.681
Positive Predictive Value	0.788
Nr of predictions	62

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2. Individual counts for RNAalifold(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.87	0.84	0.90	385	1085172	61	7	37	17	73
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.87	371	1141890	74	12	43	19	103
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.83	0.80	0.86	374	1170779	75	11	51	13	96
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.87	372	1107390	68	12	42	14	84
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.81	0.76	0.86	361	1172324	71	11	50	10	112
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.85	0.80	0.90	382	1181529	55	14	28	13	94
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.86	0.83	0.89	381	1108875	61	12	37	12	76
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.85	0.81	0.90	376	1178461	63	6	37	20	89
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.84	0.82	0.87	380	1135841	71	13	44	14	83
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.87	371	1201597	71	12	45	14	105
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.88	372	1152500	62	12	37	13	94
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.79	0.75	0.82	355	1179984	91	17	60	14	116
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.88	368	1190777	71	7	44	20	100
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.77	0.75	0.80	332	1082242	94	12	70	12	113
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.80	0.76	0.84	358	1178455	78	13	54	11	115
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.82	0.79	0.86	373	1207803	68	15	44	9	102
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.88	378	1198495	67	12	41	14	100
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.86	0.83	0.89	378	1105903	56	14	33	9	75
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.79	0.75	0.83	364	1218705	87	17	55	15	120
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.83	0.78	0.88	373	1198502	61	12	39	10	105
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.87	363	1192322	68	14	41	13	105
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.85	0.83	0.88	376	1111859	66	12	39	15	79
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.82	0.79	0.87	363	1122332	69	11	45	13	99
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.87	360	1085185	68	13	43	12	86
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.87	368	1114849	68	12	42	14	89
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.82	0.79	0.85	359	1110374	76	14	48	14	94
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.86	349	1129851	72	10	46	16	101
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.81	0.78	0.85	360	1179994	80	12	50	18	104
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.87	360	1117845	71	12	43	16	93
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.85	363	1144916	75	12	50	13	101
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.84	0.80	0.89	363	1131350	62	12	35	15	93
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.83	0.79	0.88	364	1117844	66	13	39	14	94
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.81	0.76	0.86	361	1189232	70	13	47	10	115
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.42	0.38	0.46	176	1445467	237	39	168	30	286
CRW_00326	SSU_rRNA_eukarya links to Rfam database...	0.41	0.35	0.47	178	1627730	219	36	166	17	324
CRW_00358	SSU_rRNA_eukarya links to Rfam database...	0.43	0.38	0.49	192	1674972	227	34	167	26	315
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.39	0.34	0.45	166	1579381	248	30	176	42	316
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.43	0.38	0.49	187	1611527	222	27	169	26	309
CRW_00372	SSU_rRNA_eukarya links to Rfam database...	0.40	0.35	0.46	174	1625925	228	37	170	21	324
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.40	0.34	0.47	179	2126574	228	31	169	28	355
CRW_00386	SSU_rRNA_eukarya links to Rfam database...	0.44	0.37	0.51	193	1750879	199	35	149	15	322
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.43	0.39	0.48	191	1615105	227	43	164	20	305
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.38	0.35	0.41	171	1665811	266	36	207	23	324
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.86	373	1116333	74	11	48	15	85
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.86	0.81	0.91	361	1094062	61	7	30	24	84
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.84	0.79	0.89	358	1119354	70	6	38	26	94
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.87	0.83	0.91	368	1098500	61	9	26	26	78
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.42	0.38	0.48	182	1636762	232	39	162	31	299
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.78	0.74	0.83	298	945642	94	6	54	34	106
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.82	0.78	0.87	348	1137388	80	6	44	30	99
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.74	0.70	0.79	276	1152572	131	10	63	58	118
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.78	0.74	0.82	350	1117832	97	13	65	19	120
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.84	0.81	0.88	374	1135854	61	12	38	11	90
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.47	0.42	0.53	210	1606133	216	27	158	31	293
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.44	0.38	0.50	193	1593619	210	32	161	17	313
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.78	0.71	0.86	353	1073436	80	10	46	24	142
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.75	0.65	0.86	347	1500373	97	7	51	39	188
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.73	0.62	0.86	341	1471072	93	2	55	36	206
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.75	0.65	0.87	364	1606111	77	8	45	24	198
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.76	0.67	0.87	360	1433555	85	3	53	29	180
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.72	0.65	0.80	341	1204702	101	13	72	16	186
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.78	0.71	0.86	347	1117857	83	8	48	27	144

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

2. Individual counts for RNAalifold(seed) [ download as .csv ]

Performance of RNAalifold(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNAalifold(20)

2. Individual counts for RNAalifold(20) [ download as .csv ]