CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RSpredict(20)		PknotsRG
MCC	0.686	>	0.450
Average MCC ± 95% Confidence Intervals	0.685 ± 0.014	>	0.448 ± 0.036
Sensitivity	0.621	>	0.444
Positive Predictive Value	0.759	>	0.456
Total TP	13255	>	9486
Total TN	52694012	>	52690681
Total FP	5430	<	12203
Total FP CONTRA	738	<	1478
Total FP INCONS	3478	<	9838
Total FP COMP	1214	>	887
Total FN	8099	<	11868
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RSpredict(20) and PknotsRG. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RSpredict(20) and PknotsRG).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RSpredict(20) and PknotsRG).
Comparison of average Matthews Correlation Coefficients (MCCs) for RSpredict(20) and PknotsRG. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RSpredict(20) and PknotsRG).

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Performance of RSpredict(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(20)

Total Base Pair Counts
Total TP	13255
Total TN	52694012
Total FP	5430
Total FP CONTRA	738
Total FP INCONS	3478
Total FP COMP	1214
Total FN	8099

Total Scores
MCC	0.686
Average MCC ± 95% Confidence Intervals	0.685 ± 0.014
Sensitivity	0.621
Positive Predictive Value	0.759
Nr of predictions	46

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2. Individual counts for RSpredict(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.78	0.76	0.80	349	1085166	117	16	70	31	109
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.60	0.50	0.71	239	1141980	119	16	81	22	235
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.74	0.71	0.78	332	1170788	124	21	74	29	138
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.72	0.68	0.76	308	1107412	121	17	79	25	148
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.73	0.68	0.78	320	1172336	118	19	71	28	153
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	260	1181590	123	18	85	20	216
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.73	0.69	0.77	314	1108895	119	18	78	23	143
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.73	0.69	0.78	320	1178470	123	16	74	33	145
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.73	0.68	0.79	316	1135876	116	15	71	30	147
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.72	0.67	0.77	320	1201607	124	19	79	26	156
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.73	0.68	0.79	315	1152520	110	20	66	24	151
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.71	0.65	0.77	308	1180015	120	17	76	27	163
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.73	0.68	0.79	317	1190796	115	15	68	32	151
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.68	0.63	0.74	281	1082274	126	20	81	25	164
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.66	0.60	0.74	283	1178495	122	22	80	20	190
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.71	0.67	0.76	316	1207819	125	23	77	25	159
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.72	0.67	0.77	319	1198513	119	20	74	25	159
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.70	0.63	0.78	285	1105963	105	14	66	25	168
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.71	0.67	0.76	322	1218719	127	19	81	27	162
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.72	0.66	0.78	317	1198517	119	19	73	27	161
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.71	0.62	0.81	292	1192380	91	18	50	23	176
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.68	0.60	0.77	272	1111934	101	13	67	21	183
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.70	0.65	0.75	301	1122349	125	21	80	24	161
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.67	0.60	0.76	266	1085250	106	16	69	21	180
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.73	0.69	0.77	315	1114864	116	18	74	24	142
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.71	244	1110451	120	17	83	20	209
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.60	0.51	0.71	231	1129930	115	14	81	20	219
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.71	0.66	0.75	308	1180005	131	20	83	28	156
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.71	0.66	0.75	300	1117861	125	19	80	26	153
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.72	0.67	0.77	311	1144937	123	15	78	30	153
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.71	0.66	0.77	301	1131370	113	18	71	24	155
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.64	0.55	0.73	254	1117913	115	15	78	22	204
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.70	0.66	0.76	312	1189241	126	19	81	26	164
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.73	258	1116413	115	15	79	21	200
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.64	0.55	0.75	244	1094136	105	9	71	25	201
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.73	249	1119415	115	6	86	23	203
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.70	0.63	0.76	283	1098533	118	13	74	31	163
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.59	0.49	0.71	196	945723	109	10	71	28	208
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.75	254	1137446	113	13	73	27	193
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.63	0.53	0.75	209	1152644	114	10	58	46	185
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.61	0.51	0.72	241	1117925	111	14	80	17	229
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.73	0.69	0.77	319	1135862	125	18	79	28	145
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.67	0.60	0.75	297	1073447	132	13	88	31	198
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.61	0.50	0.75	270	1433609	124	8	84	32	270
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.64	0.54	0.76	282	1204758	129	8	80	41	245
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.69	0.62	0.77	305	1117865	121	14	76	31	186

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Performance of PknotsRG - scored lower in this pairwise comparison

1. Total counts & total scores for PknotsRG

Total Base Pair Counts
Total TP	9486
Total TN	52690681
Total FP	12203
Total FP CONTRA	1478
Total FP INCONS	9838
Total FP COMP	887
Total FN	11868

Total Scores
MCC	0.450
Average MCC ± 95% Confidence Intervals	0.448 ± 0.036
Sensitivity	0.444
Positive Predictive Value	0.456
Nr of predictions	46

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2. Individual counts for PknotsRG [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.77	0.76	0.79	348	1085160	130	18	75	37	110
CRW_00034	SSU_rRNA_bacteria links to Rfam database...	0.63	0.63	0.63	300	1141843	196	31	142	23	174
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.45	0.45	0.45	210	1170748	276	27	230	19	260
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.53	0.52	0.54	236	1107378	216	34	168	14	220
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.50	0.49	0.51	233	1172293	234	28	192	14	240
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.43	0.44	0.43	208	1181469	284	32	244	8	268
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.33	0.33	0.34	152	1108852	312	37	264	11	305
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.55	0.55	0.55	255	1178420	227	21	184	22	210
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.64	0.64	0.65	296	1135820	182	22	140	20	167
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.52	238	1201566	240	29	192	19	238
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.41	0.41	0.42	190	1152467	282	34	230	18	276
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.52	236	1179961	240	37	182	21	235
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.53	0.52	0.54	242	1190746	234	25	183	26	226
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.29	0.29	0.29	128	1082212	325	37	279	9	317
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.42	0.41	0.42	196	1178413	284	31	240	13	277
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.47	0.46	0.47	220	1207767	270	26	222	22	255
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.55	0.54	0.57	260	1198467	221	30	169	22	218
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.35	0.35	0.34	157	1105872	312	45	254	13	296
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.57	0.57	0.58	275	1218668	230	24	174	32	209
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.43	0.43	0.43	205	1198449	287	30	242	15	273
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.45	0.44	0.46	206	1192291	257	41	202	14	262
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.38	0.37	0.39	168	1111857	279	39	222	18	287
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.50	220	1122307	239	36	188	15	242
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.51	222	1085169	227	31	179	17	224
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.42	0.42	0.43	193	1114817	278	26	235	17	264
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.25	0.25	0.24	113	1110332	354	55	295	4	340
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.42	180	1129825	270	35	216	19	270
CRW_00279	SSU_rRNA_bacteria links to Rfam database...	0.29	0.29	0.30	134	1179968	334	40	274	20	330
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.50	0.50	0.51	226	1117813	234	28	193	13	227
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.30	0.30	0.30	138	1144878	340	40	285	15	326
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.26	0.25	0.26	115	1131320	336	35	290	11	341
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.47	0.47	0.47	214	1117807	257	31	208	18	244
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.45	0.44	0.46	209	1189197	272	34	213	25	267
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.61	0.60	0.62	273	1116325	194	25	142	27	185
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.22	0.21	0.22	95	1094029	351	37	299	15	350
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.32	0.31	0.33	141	1119330	303	41	244	18	311
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.61	0.60	0.62	267	1098475	190	19	142	29	179
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.24	0.24	0.25	97	945607	320	41	255	24	307
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.35	0.35	0.35	156	1137342	304	48	240	16	291
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.24	0.25	0.23	98	1152503	357	51	269	37	296
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.48	0.48	0.49	225	1117798	260	25	212	23	245
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.52	0.52	0.52	239	1135819	238	24	196	18	225
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.50	0.48	0.53	239	1073392	239	21	193	25	256
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.52	269	1433453	278	27	222	29	271
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.48	0.45	0.51	239	1204657	247	27	205	15	288
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.47	0.46	0.49	225	1117799	263	23	213	27	266

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RSpredict(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(20)

2. Individual counts for RSpredict(20) [ download as .csv ]

Performance of PknotsRG - scored lower in this pairwise comparison

1. Total counts & total scores for PknotsRG

2. Individual counts for PknotsRG [ download as .csv ]