CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RSpredict(seed)		Contrafold
MCC	0.532	>	0.508
Average MCC ± 95% Confidence Intervals	0.529 ± 0.062	>	0.507 ± 0.028
Sensitivity	0.447	<	0.485
Positive Predictive Value	0.632	>	0.532
Total TP	12037	<	13039
Total TN	71042306	>	71036856
Total FP	8416	<	13298
Total FP CONTRA	1137	<	1554
Total FP INCONS	5864	<	9895
Total FP COMP	1415	<	1849
Total FN	14867	>	13865
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RSpredict(seed) and Contrafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RSpredict(seed) and Contrafold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RSpredict(seed) and Contrafold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RSpredict(seed) and Contrafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RSpredict(seed) and Contrafold).

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Performance of RSpredict(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP	12037
Total TN	71042306
Total FP	8416
Total FP CONTRA	1137
Total FP INCONS	5864
Total FP COMP	1415
Total FN	14867

Total Scores
MCC	0.532
Average MCC ± 95% Confidence Intervals	0.529 ± 0.062
Sensitivity	0.447
Positive Predictive Value	0.632
Nr of predictions	57

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.78	0.76	0.80	346	1085169	116	15	71	30	112
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.74	268	1170853	120	15	79	26	202
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.66	0.59	0.75	269	1107457	114	15	75	24	187
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.73	257	1172394	120	18	77	25	216
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.72	258	1181594	124	19	82	23	218
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.75	261	1108955	113	16	73	24	196
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.66	0.57	0.75	267	1178524	119	14	75	30	198
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.67	0.59	0.76	273	1135921	112	13	71	28	190
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	260	1201662	126	16	87	23	216
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.66	0.58	0.74	270	1152558	117	19	74	24	196
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.74	252	1180075	110	15	74	21	219
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.64	0.55	0.74	258	1190849	118	11	78	29	210
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.62	0.55	0.71	243	1082316	119	17	80	22	202
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.67	0.58	0.77	274	1178524	103	15	67	21	199
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.73	257	1207883	117	16	79	22	218
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.71	257	1198565	127	16	88	23	221
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	248	1105984	121	17	79	25	205
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.75	278	1218768	123	17	78	28	206
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.67	0.60	0.74	285	1198543	124	18	80	26	193
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.72	251	1192392	119	17	80	22	217
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.74	255	1111941	113	15	75	23	200
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.62	0.53	0.73	243	1122417	115	15	76	24	219
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.73	250	1085260	113	15	76	22	196
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.72	249	1114926	120	15	81	24	208
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.61	0.52	0.72	235	1110468	113	17	75	21	218
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.61	0.53	0.70	240	1117918	122	15	87	20	213
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.65	0.56	0.74	260	1144991	117	12	78	27	204
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.53	0.42	0.68	180	1015761	96	14	70	12	252
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.60	0.50	0.70	240	1189312	122	16	85	21	236
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.55	0.43	0.72	196	1123976	99	12	66	21	265
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1445558	306	53	239	14	462
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1579464	301	50	239	12	482
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1611598	319	50	262	7	496
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	2126581	414	77	295	42	534
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1615206	309	45	252	12	496
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1665933	312	53	239	20	495
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.64	0.55	0.74	252	1116423	114	13	77	24	206
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.63	0.53	0.74	236	1094141	110	9	74	27	209
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.64	0.54	0.76	245	1119432	103	8	71	24	207
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.66	0.58	0.76	258	1098562	118	11	72	35	188
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	1	1636859	310	50	235	25	480
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.62	0.49	0.79	217	1215744	86	5	54	27	229
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.59	0.48	0.73	185	1201773	99	7	60	32	199
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.74	249	1137451	114	13	73	28	198
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.58	0.47	0.72	184	1152666	117	7	64	46	210
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.60	0.49	0.73	232	1117943	100	11	74	15	238
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	256	1135921	123	14	87	22	208
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1606225	319	65	238	16	503
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1593701	318	50	254	14	506
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.52	0.41	0.68	177	977639	95	12	73	10	257
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.63	0.53	0.76	261	1073500	115	11	73	31	234
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.60	0.48	0.76	259	1500435	126	9	75	42	276
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.60	0.47	0.76	259	1471129	122	8	74	40	288
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.60	0.47	0.76	266	1606178	119	12	72	35	296
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.61	0.50	0.76	268	1433617	119	7	79	33	272
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.64	0.53	0.78	280	1204768	120	9	71	40	247
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.65	0.55	0.76	272	1117903	116	13	72	31	219

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Performance of Contrafold - scored lower in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP	13039
Total TN	71036856
Total FP	13298
Total FP CONTRA	1554
Total FP INCONS	9895
Total FP COMP	1849
Total FN	13865

Total Scores
MCC	0.508
Average MCC ± 95% Confidence Intervals	0.507 ± 0.028
Sensitivity	0.485
Positive Predictive Value	0.532
Nr of predictions	57

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2. Individual counts for Contrafold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.77	0.77	0.78	351	1085153	140	12	85	43	107
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.60	0.57	0.64	268	1170795	174	25	127	22	202
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.54	0.52	0.56	237	1107395	202	25	159	18	219
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.64	0.60	0.67	286	1172318	164	20	122	22	187
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.59	0.58	0.61	274	1181504	188	29	146	13	202
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.51	0.51	0.53	231	1108865	226	32	177	17	226
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.55	0.53	0.57	245	1178450	213	19	166	28	220
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.56	0.52	0.61	243	1135878	175	14	143	18	220
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.62	0.60	0.64	287	1201577	192	19	142	31	189
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.55	0.51	0.59	237	1152519	185	22	143	20	229
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.53	0.49	0.57	233	1180006	196	22	155	19	238
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.62	0.59	0.64	277	1190763	182	19	137	26	191
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.34	0.34	0.35	150	1082228	288	32	246	10	295
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.50	0.48	0.52	228	1178444	227	20	188	19	245
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.57	0.55	0.59	259	1207798	197	27	151	19	216
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.54	0.52	0.56	250	1198476	220	27	173	20	228
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.53	0.51	0.55	229	1105912	212	23	164	25	224
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.64	0.62	0.66	301	1218683	200	21	136	43	183
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.58	0.56	0.61	267	1198490	184	24	145	15	211
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.47	0.44	0.50	206	1192327	232	26	181	25	262
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.66	0.63	0.69	286	1111874	157	20	106	31	169
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.51	0.48	0.53	221	1122337	215	30	163	22	241
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.47	0.46	0.49	203	1085190	233	20	188	25	243
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.61	0.59	0.63	271	1114843	186	19	138	29	186
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.44	0.40	0.49	182	1110423	203	23	167	13	271
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.55	0.51	0.60	232	1117873	173	15	140	18	221
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.64	0.62	0.65	288	1144901	182	17	135	30	176
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.41	0.38	0.45	162	1015668	217	29	166	22	270
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.60	0.57	0.63	270	1189221	197	21	141	35	206
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.38	0.36	0.40	165	1123842	258	35	208	15	296
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.28	0.28	0.29	129	1445402	388	63	256	69	333
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.33	0.33	0.33	157	1579284	361	57	255	49	325
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.44	0.41	0.46	205	1611467	295	42	196	57	291
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.43	0.42	0.44	223	2126443	372	38	249	85	311
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.39	0.36	0.42	181	1615070	306	41	211	54	315
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.36	0.37	0.36	181	1665721	382	54	269	59	314
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.70	0.68	0.73	312	1116336	148	19	98	31	146
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.33	0.30	0.36	134	1094090	257	24	212	21	311
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.36	0.35	0.38	157	1119345	281	41	213	27	295
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.62	0.60	0.65	268	1098489	182	28	118	36	178
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.31	0.30	0.32	145	1636697	372	51	252	69	336
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.38	0.32	0.44	144	1215694	231	27	155	49	302
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.52	0.45	0.59	174	1201730	163	16	105	42	210
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.48	0.44	0.53	196	1137416	209	14	160	35	251
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.35	0.33	0.38	131	1152575	263	22	193	48	263
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.57	0.56	0.57	265	1117797	226	19	179	28	205
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.62	0.60	0.64	280	1135838	187	19	141	27	184
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.39	0.39	0.40	194	1606043	347	52	239	56	309
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.45	0.44	0.47	221	1593534	302	49	201	52	285
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.46	0.44	0.48	189	977509	217	30	173	14	245
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.53	0.50	0.56	246	1073403	229	19	177	33	249
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.50	0.49	0.52	264	1500266	296	25	223	48	271
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.46	0.43	0.49	236	1470988	271	34	212	25	311
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.55	0.54	0.56	301	1605989	279	31	207	41	261
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.58	0.56	0.60	303	1433467	242	16	185	41	237
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.49	0.44	0.55	232	1204703	216	20	173	23	295
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.49	0.47	0.51	232	1117807	258	16	205	37	259

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RSpredict(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

2. Individual counts for RSpredict(seed) [ download as .csv ]

Performance of Contrafold - scored lower in this pairwise comparison

1. Total counts & total scores for Contrafold

2. Individual counts for Contrafold [ download as .csv ]