CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RSpredict(seed)		ProbKnot
MCC	0.532	>	0.430
Average MCC ± 95% Confidence Intervals	0.529 ± 0.062	>	0.430 ± 0.029
Sensitivity	0.447	>	0.422
Positive Predictive Value	0.632	>	0.439
Total TP	12037	>	11343
Total TN	71042306	>	71035496
Total FP	8416	<	16334
Total FP CONTRA	1137	<	2269
Total FP INCONS	5864	<	12236
Total FP COMP	1415	<	1829
Total FN	14867	<	15561
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RSpredict(seed) and ProbKnot. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RSpredict(seed) and ProbKnot).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RSpredict(seed) and ProbKnot).
Comparison of average Matthews Correlation Coefficients (MCCs) for RSpredict(seed) and ProbKnot. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RSpredict(seed) and ProbKnot).

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Performance of RSpredict(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP	12037
Total TN	71042306
Total FP	8416
Total FP CONTRA	1137
Total FP INCONS	5864
Total FP COMP	1415
Total FN	14867

Total Scores
MCC	0.532
Average MCC ± 95% Confidence Intervals	0.529 ± 0.062
Sensitivity	0.447
Positive Predictive Value	0.632
Nr of predictions	57

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.78	0.76	0.80	346	1085169	116	15	71	30	112
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.74	268	1170853	120	15	79	26	202
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.66	0.59	0.75	269	1107457	114	15	75	24	187
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.73	257	1172394	120	18	77	25	216
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.72	258	1181594	124	19	82	23	218
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.75	261	1108955	113	16	73	24	196
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.66	0.57	0.75	267	1178524	119	14	75	30	198
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.67	0.59	0.76	273	1135921	112	13	71	28	190
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	260	1201662	126	16	87	23	216
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.66	0.58	0.74	270	1152558	117	19	74	24	196
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.74	252	1180075	110	15	74	21	219
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.64	0.55	0.74	258	1190849	118	11	78	29	210
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.62	0.55	0.71	243	1082316	119	17	80	22	202
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.67	0.58	0.77	274	1178524	103	15	67	21	199
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.73	257	1207883	117	16	79	22	218
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.71	257	1198565	127	16	88	23	221
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	248	1105984	121	17	79	25	205
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.75	278	1218768	123	17	78	28	206
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.67	0.60	0.74	285	1198543	124	18	80	26	193
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.72	251	1192392	119	17	80	22	217
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.74	255	1111941	113	15	75	23	200
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.62	0.53	0.73	243	1122417	115	15	76	24	219
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.73	250	1085260	113	15	76	22	196
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.72	249	1114926	120	15	81	24	208
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.61	0.52	0.72	235	1110468	113	17	75	21	218
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.61	0.53	0.70	240	1117918	122	15	87	20	213
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.65	0.56	0.74	260	1144991	117	12	78	27	204
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.53	0.42	0.68	180	1015761	96	14	70	12	252
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.60	0.50	0.70	240	1189312	122	16	85	21	236
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.55	0.43	0.72	196	1123976	99	12	66	21	265
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1445558	306	53	239	14	462
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1579464	301	50	239	12	482
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1611598	319	50	262	7	496
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	2126581	414	77	295	42	534
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1615206	309	45	252	12	496
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1665933	312	53	239	20	495
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.64	0.55	0.74	252	1116423	114	13	77	24	206
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.63	0.53	0.74	236	1094141	110	9	74	27	209
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.64	0.54	0.76	245	1119432	103	8	71	24	207
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.66	0.58	0.76	258	1098562	118	11	72	35	188
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	1	1636859	310	50	235	25	480
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.62	0.49	0.79	217	1215744	86	5	54	27	229
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.59	0.48	0.73	185	1201773	99	7	60	32	199
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.74	249	1137451	114	13	73	28	198
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.58	0.47	0.72	184	1152666	117	7	64	46	210
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.60	0.49	0.73	232	1117943	100	11	74	15	238
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	256	1135921	123	14	87	22	208
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1606225	319	65	238	16	503
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1593701	318	50	254	14	506
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.52	0.41	0.68	177	977639	95	12	73	10	257
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.63	0.53	0.76	261	1073500	115	11	73	31	234
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.60	0.48	0.76	259	1500435	126	9	75	42	276
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.60	0.47	0.76	259	1471129	122	8	74	40	288
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.60	0.47	0.76	266	1606178	119	12	72	35	296
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.61	0.50	0.76	268	1433617	119	7	79	33	272
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.64	0.53	0.78	280	1204768	120	9	71	40	247
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.65	0.55	0.76	272	1117903	116	13	72	31	219

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Performance of ProbKnot - scored lower in this pairwise comparison

1. Total counts & total scores for ProbKnot

Total Base Pair Counts
Total TP	11343
Total TN	71035496
Total FP	16334
Total FP CONTRA	2269
Total FP INCONS	12236
Total FP COMP	1829
Total FN	15561

Total Scores
MCC	0.430
Average MCC ± 95% Confidence Intervals	0.430 ± 0.029
Sensitivity	0.422
Positive Predictive Value	0.439
Nr of predictions	57

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2. Individual counts for ProbKnot [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.69	0.68	0.70	312	1085154	184	22	113	49	146
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.48	0.46	0.51	215	1170796	225	31	173	21	255
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.42	0.41	0.43	186	1107383	267	27	220	20	270
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.50	0.48	0.52	225	1172311	230	27	183	20	248
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.43	0.42	0.44	201	1181493	284	39	220	25	275
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.45	0.43	0.47	198	1108880	243	33	194	16	259
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.50	222	1178435	246	25	198	23	243
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.41	185	1135829	286	31	233	22	278
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.54	0.52	0.55	248	1201576	229	30	171	28	228
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.44	0.42	0.45	198	1152481	263	27	215	21	268
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.58	0.56	0.60	265	1179971	202	39	141	22	206
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.42	0.41	0.44	190	1190764	263	30	212	21	278
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.27	0.26	0.27	115	1082237	320	30	274	16	330
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.48	0.46	0.51	219	1178447	241	25	189	27	254
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.50	229	1207778	250	33	195	22	246
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.56	0.53	0.59	255	1198497	206	24	150	32	223
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.40	0.40	0.41	179	1105891	278	32	226	20	274
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.52	0.52	0.53	250	1218666	257	31	194	32	234
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.50	0.50	0.50	238	1198447	265	46	195	24	240
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.40	0.40	0.41	185	1192284	296	39	232	25	283
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.53	0.53	0.54	241	1111840	228	28	177	23	214
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.35	0.33	0.36	154	1122325	292	38	234	20	308
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.43	0.41	0.45	183	1085197	235	32	189	14	263
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.60	0.58	0.61	266	1114835	193	26	144	23	191
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.36	0.35	0.37	157	1110374	282	40	224	18	296
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.36	0.35	0.38	158	1117841	277	40	221	16	295
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.58	0.56	0.59	260	1144904	208	25	152	31	204
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.37	0.38	0.37	162	1015591	302	49	223	30	270
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.49	0.48	0.50	228	1189195	264	43	187	34	248
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.35	0.34	0.36	157	1123815	302	48	230	24	304
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.18	0.19	0.18	86	1445359	473	69	336	68	376
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.26	0.27	0.25	130	1579227	438	85	311	42	352
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.39	0.39	0.40	191	1611430	345	53	236	56	305
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.42	0.43	0.41	229	2126396	414	75	253	86	305
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.34	0.35	0.33	172	1614983	394	81	267	46	324
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.29	0.30	0.29	149	1665709	429	66	301	62	346
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.60	0.59	0.60	272	1116312	211	33	148	30	186
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.31	0.30	0.32	135	1094033	316	46	246	24	310
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.41	0.39	0.43	176	1119350	259	29	201	29	276
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.44	0.44	0.44	198	1098453	275	46	206	23	248
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.31	0.31	0.30	151	1636639	423	69	286	68	330
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.20	0.20	0.20	90	1215575	395	47	308	40	356
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.29	0.29	0.28	112	1201627	335	46	240	49	272
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.36	0.36	0.37	163	1137340	312	43	240	29	284
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.34	0.34	0.33	135	1152513	326	45	228	53	259
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.57	0.56	0.58	263	1117810	226	18	169	39	207
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.44	0.42	0.46	197	1135851	249	39	191	19	267
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.29	0.30	0.28	150	1605991	434	63	324	47	353
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.33	0.33	0.33	168	1593497	395	62	278	55	338
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.37	0.36	0.38	158	977480	279	40	223	16	276
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.56	0.51	0.61	253	1073430	187	22	140	25	242
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.56	0.54	0.58	288	1500280	260	33	177	50	247
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.33	0.32	0.34	175	1470956	367	49	290	28	372
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.61	0.58	0.64	324	1606022	220	26	156	38	238
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.57	0.53	0.62	286	1433506	213	32	147	34	254
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.43	0.40	0.47	211	1204677	265	29	211	25	316
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.43	0.41	0.45	200	1117813	276	33	214	29	291

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RSpredict(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

2. Individual counts for RSpredict(seed) [ download as .csv ]

Performance of ProbKnot - scored lower in this pairwise comparison

1. Total counts & total scores for ProbKnot

2. Individual counts for ProbKnot [ download as .csv ]