CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RSpredict(seed)		Sfold
MCC	0.532	>	0.480
Average MCC ± 95% Confidence Intervals	0.529 ± 0.062	>	0.478 ± 0.033
Sensitivity	0.447	>	0.423
Positive Predictive Value	0.632	>	0.544
Total TP	12037	>	11380
Total TN	71042306	>	71040435
Total FP	8416	<	10929
Total FP CONTRA	1137	<	1368
Total FP INCONS	5864	<	8161
Total FP COMP	1415	>	1400
Total FN	14867	<	15524
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RSpredict(seed) and Sfold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RSpredict(seed) and Sfold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RSpredict(seed) and Sfold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RSpredict(seed) and Sfold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RSpredict(seed) and Sfold).

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Performance of RSpredict(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP	12037
Total TN	71042306
Total FP	8416
Total FP CONTRA	1137
Total FP INCONS	5864
Total FP COMP	1415
Total FN	14867

Total Scores
MCC	0.532
Average MCC ± 95% Confidence Intervals	0.529 ± 0.062
Sensitivity	0.447
Positive Predictive Value	0.632
Nr of predictions	57

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.78	0.76	0.80	346	1085169	116	15	71	30	112
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.74	268	1170853	120	15	79	26	202
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.66	0.59	0.75	269	1107457	114	15	75	24	187
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.73	257	1172394	120	18	77	25	216
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.72	258	1181594	124	19	82	23	218
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.75	261	1108955	113	16	73	24	196
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.66	0.57	0.75	267	1178524	119	14	75	30	198
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.67	0.59	0.76	273	1135921	112	13	71	28	190
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	260	1201662	126	16	87	23	216
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.66	0.58	0.74	270	1152558	117	19	74	24	196
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.74	252	1180075	110	15	74	21	219
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.64	0.55	0.74	258	1190849	118	11	78	29	210
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.62	0.55	0.71	243	1082316	119	17	80	22	202
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.67	0.58	0.77	274	1178524	103	15	67	21	199
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.73	257	1207883	117	16	79	22	218
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.71	257	1198565	127	16	88	23	221
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	248	1105984	121	17	79	25	205
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.65	0.57	0.75	278	1218768	123	17	78	28	206
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.67	0.60	0.74	285	1198543	124	18	80	26	193
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.62	0.54	0.72	251	1192392	119	17	80	22	217
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.74	255	1111941	113	15	75	23	200
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.62	0.53	0.73	243	1122417	115	15	76	24	219
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.73	250	1085260	113	15	76	22	196
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.63	0.54	0.72	249	1114926	120	15	81	24	208
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.61	0.52	0.72	235	1110468	113	17	75	21	218
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.61	0.53	0.70	240	1117918	122	15	87	20	213
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.65	0.56	0.74	260	1144991	117	12	78	27	204
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.53	0.42	0.68	180	1015761	96	14	70	12	252
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.60	0.50	0.70	240	1189312	122	16	85	21	236
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.55	0.43	0.72	196	1123976	99	12	66	21	265
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1445558	306	53	239	14	462
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1579464	301	50	239	12	482
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1611598	319	50	262	7	496
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	2126581	414	77	295	42	534
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1615206	309	45	252	12	496
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1665933	312	53	239	20	495
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.64	0.55	0.74	252	1116423	114	13	77	24	206
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.63	0.53	0.74	236	1094141	110	9	74	27	209
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.64	0.54	0.76	245	1119432	103	8	71	24	207
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.66	0.58	0.76	258	1098562	118	11	72	35	188
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	1	1636859	310	50	235	25	480
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.62	0.49	0.79	217	1215744	86	5	54	27	229
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.59	0.48	0.73	185	1201773	99	7	60	32	199
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.64	0.56	0.74	249	1137451	114	13	73	28	198
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.58	0.47	0.72	184	1152666	117	7	64	46	210
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.60	0.49	0.73	232	1117943	100	11	74	15	238
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.63	0.55	0.72	256	1135921	123	14	87	22	208
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1606225	319	65	238	16	503
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.00	0.00	0.00	0	1593701	318	50	254	14	506
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.52	0.41	0.68	177	977639	95	12	73	10	257
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.63	0.53	0.76	261	1073500	115	11	73	31	234
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.60	0.48	0.76	259	1500435	126	9	75	42	276
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.60	0.47	0.76	259	1471129	122	8	74	40	288
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.60	0.47	0.76	266	1606178	119	12	72	35	296
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.61	0.50	0.76	268	1433617	119	7	79	33	272
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.64	0.53	0.78	280	1204768	120	9	71	40	247
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.65	0.55	0.76	272	1117903	116	13	72	31	219

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Performance of Sfold - scored lower in this pairwise comparison

1. Total counts & total scores for Sfold

Total Base Pair Counts
Total TP	11380
Total TN	71040435
Total FP	10929
Total FP CONTRA	1368
Total FP INCONS	8161
Total FP COMP	1400
Total FN	15524

Total Scores
MCC	0.480
Average MCC ± 95% Confidence Intervals	0.478 ± 0.033
Sensitivity	0.423
Positive Predictive Value	0.544
Nr of predictions	57

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2. Individual counts for Sfold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.80	0.77	0.83	352	1085176	112	13	60	39	106
CRW_00048	SSU_rRNA_bacteria links to Rfam database...	0.50	0.45	0.54	213	1170824	198	17	161	20	257
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.48	0.43	0.54	195	1107453	185	23	145	17	261
CRW_00059	SSU_rRNA_bacteria links to Rfam database...	0.54	0.49	0.60	232	1172361	169	19	134	16	241
CRW_00061	SSU_rRNA_bacteria links to Rfam database...	0.49	0.45	0.54	215	1181555	193	31	152	10	261
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.48	0.43	0.53	196	1108938	184	19	152	13	261
CRW_00096	SSU_rRNA_bacteria links to Rfam database...	0.59	0.55	0.63	258	1178469	180	16	137	27	207
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.66	0.60	0.73	280	1135893	125	10	95	20	183
CRW_00141	SSU_rRNA_bacteria links to Rfam database...	0.63	0.57	0.70	272	1201636	139	16	101	22	204
CRW_00150	SSU_rRNA_bacteria links to Rfam database...	0.40	0.37	0.44	171	1152531	233	30	189	14	295
CRW_00152	SSU_rRNA_bacteria links to Rfam database...	0.67	0.61	0.74	287	1180029	118	21	79	18	184
CRW_00166	SSU_rRNA_bacteria links to Rfam database...	0.54	0.47	0.61	221	1190832	160	15	128	17	247
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.36	0.32	0.39	144	1082291	233	16	205	12	301
CRW_00177	SSU_rRNA_bacteria links to Rfam database...	0.45	0.41	0.50	195	1178491	206	27	167	12	278
CRW_00196	SSU_rRNA_bacteria links to Rfam database...	0.47	0.44	0.50	210	1207811	232	23	191	18	265
CRW_00230	SSU_rRNA_bacteria links to Rfam database...	0.61	0.53	0.70	254	1198565	129	7	100	22	224
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.54	0.45	0.66	202	1106023	115	16	87	12	251
CRW_00248	SSU_rRNA_bacteria links to Rfam database...	0.58	0.57	0.59	274	1218677	223	21	169	33	210
CRW_00250	SSU_rRNA_bacteria links to Rfam database...	0.50	0.46	0.54	221	1198516	206	28	161	17	257
CRW_00256	SSU_rRNA_bacteria links to Rfam database...	0.37	0.33	0.42	155	1192370	232	35	180	17	313
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.48	0.39	0.59	178	1111985	137	19	104	14	277
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.49	0.43	0.57	198	1122402	170	32	119	19	264
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.55	0.50	0.61	224	1085232	162	22	123	17	222
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.58	0.47	0.73	213	1114978	98	14	66	18	244
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.40	0.30	0.54	136	1110544	127	18	97	12	317
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.60	0.55	0.66	250	1117881	149	21	108	20	203
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.68	0.60	0.77	279	1144977	109	11	74	24	185
CRW_00283	SSU_rRNA_bacteria links to Rfam database...	0.31	0.24	0.40	102	1015772	167	19	132	16	330
CRW_00289	SSU_rRNA_bacteria links to Rfam database...	0.59	0.51	0.68	241	1189298	141	19	95	27	235
CRW_00292	SSU_rRNA_bacteria links to Rfam database...	0.36	0.31	0.41	142	1123904	219	35	169	15	319
CRW_00306	SSU_rRNA_eukarya links to Rfam database...	0.21	0.19	0.24	88	1445476	332	57	229	46	374
CRW_00366	SSU_rRNA_eukarya links to Rfam database...	0.36	0.35	0.36	169	1579286	334	74	224	36	313
CRW_00371	SSU_rRNA_eukarya links to Rfam database...	0.38	0.34	0.42	171	1611504	271	50	185	36	325
CRW_00379	SSU_rRNA_eukarya links to Rfam database...	0.44	0.34	0.58	183	2126636	205	17	117	71	351
CRW_00411	SSU_rRNA_eukarya links to Rfam database...	0.39	0.32	0.47	157	1615171	217	28	147	42	339
CRW_00414	SSU_rRNA_eukarya links to Rfam database...	0.33	0.29	0.38	146	1665840	278	40	199	39	349
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.57	0.54	0.61	247	1116358	185	18	142	25	211
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.31	0.26	0.36	116	1094139	220	19	186	15	329
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.58	0.40	0.84	179	1119542	50	5	30	15	273
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.60	0.56	0.65	248	1098523	153	22	110	21	198
CRW_00759	SSU_rRNA_eukarya links to Rfam database...	0.23	0.22	0.25	105	1636722	354	42	276	36	376
CRW_00763	SSU_rRNA_bacteria links to Rfam database...	0.33	0.28	0.40	124	1215709	234	16	171	47	322
CRW_00778	SSU_rRNA_bacteria links to Rfam database...	0.42	0.29	0.62	111	1201847	113	3	64	46	273
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.40	0.34	0.46	152	1137458	193	30	146	17	295
CRW_00795	SSU_rRNA_bacteria links to Rfam database...	0.19	0.17	0.20	68	1152586	311	44	223	44	326
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.50	0.48	0.52	227	1117826	230	18	189	23	243
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.59	0.52	0.66	241	1135913	144	19	105	20	223
CRW_01153	SSU_rRNA_eukarya links to Rfam database...	0.37	0.30	0.45	152	1606193	221	35	148	38	351
CRW_01171	SSU_rRNA_eukarya links to Rfam database...	0.33	0.29	0.38	149	1593608	285	55	193	37	357
CRW_01343	SSU_rRNA_archaea links to Rfam database...	0.37	0.34	0.41	147	977541	224	31	182	11	287
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.52	0.46	0.58	229	1073451	189	12	153	24	266
PDB_00854	SSU_rRNA_bacteria links to Rfam database...	0.54	0.49	0.60	263	1500337	220	22	156	42	272
PDB_01088	SSU_rRNA_bacteria links to Rfam database...	0.38	0.32	0.47	173	1471098	222	33	166	23	374
PDB_01103	SSU_rRNA_bacteria links to Rfam database...	0.56	0.50	0.63	280	1606082	191	20	146	25	282
PDB_01105	SSU_rRNA_bacteria links to Rfam database...	0.60	0.53	0.67	288	1433540	169	14	129	26	252
PDB_01120	SSU_rRNA_bacteria links to Rfam database...	0.55	0.44	0.70	230	1204799	110	12	87	11	297
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.50	0.46	0.54	227	1117836	223	19	178	26	264

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RSpredict(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

2. Individual counts for RSpredict(seed) [ download as .csv ]

Performance of Sfold - scored lower in this pairwise comparison

1. Total counts & total scores for Sfold

2. Individual counts for Sfold [ download as .csv ]