CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Afold		CMfinder(seed)
MCC	0.522	>	0.355
Average MCC ± 95% Confidence Intervals	0.480 ± 0.104	>	0.384 ± 0.091
Sensitivity	0.512	>	0.182
Positive Predictive Value	0.533	<	0.696
Total TP	784	>	279
Total TN	945317	<	946386
Total FP	875	>	130
Total FP CONTRA	129	>	6
Total FP INCONS	557	>	116
Total FP COMP	189	>	8
Total FN	748	<	1253
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Afold and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Afold and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and CMfinder(seed)).

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Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP	784
Total TN	945317
Total FP	875
Total FP CONTRA	129
Total FP INCONS	557
Total FP COMP	189
Total FN	748

Total Scores
MCC	0.522
Average MCC ± 95% Confidence Intervals	0.480 ± 0.104
Sensitivity	0.512
Positive Predictive Value	0.533
Nr of predictions	22

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2. Individual counts for Afold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.22	0.22	0.22	25	103625	113	13	77	23	90
CRW_00016	Intron_gpI links to Rfam database...	0.65	0.62	0.69	74	77313	47	5	29	13	46
CRW_00610	Intron_gpI links to Rfam database...	0.42	0.42	0.43	34	36235	46	6	40	0	47
CRW_00613	Intron_gpI links to Rfam database...	0.46	0.42	0.51	33	34915	41	2	30	9	45
CRW_00614	Intron_gpI links to Rfam database...	0.07	0.09	0.06	5	121689	141	24	53	64	52
CRW_00633	Intron_gpI links to Rfam database...	0.45	0.44	0.47	47	63445	58	10	44	4	59
CRW_00670	Intron_gpI links to Rfam database...	0.77	0.74	0.81	89	70015	26	0	21	5	31
CRW_00671	Intron_gpI links to Rfam database...	0.66	0.64	0.68	75	62725	41	8	27	6	42
CRW_00672	Intron_gpI links to Rfam database...	0.74	0.73	0.74	81	72281	36	10	18	8	30
CRW_00674	Intron_gpI links to Rfam database...	0.55	0.55	0.55	68	83312	61	8	48	5	56
CRW_00676	Intron_gpI links to Rfam database...	0.54	0.56	0.52	64	93406	75	17	41	17	51
CRW_00692	Intron_gpI links to Rfam database...	0.57	0.57	0.57	51	68545	54	15	24	15	39
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2677	25	1	23	1	23
PDB_00827	Intron_gpI links to Rfam database...	0.67	0.59	0.76	48	26965	16	0	15	1	33
PDB_01092	glmS links to Rfam database...	0.69	0.60	0.79	31	10114	11	1	7	3	21
RFA_00632	HDV_ribozyme links to Rfam database...	0.40	0.39	0.41	11	4068	18	0	16	2	17
RFA_00636	HDV_ribozyme links to Rfam database...	0.42	0.43	0.43	12	3977	17	2	14	1	16
RFA_00769	Corona_pk3 links to Rfam database...	0.55	0.56	0.56	10	1935	10	3	5	2	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	6	0	2	4	8
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	5	1	0	4	8
RFA_00808	RydC links to Rfam database...	-0.01	0.00	0.00	0	2001	16	2	13	1	16
RFA_00809	RydC links to Rfam database...	0.36	0.38	0.35	6	2128	12	1	10	1	10

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	279
Total TN	946386
Total FP	130
Total FP CONTRA	6
Total FP INCONS	116
Total FP COMP	8
Total FN	1253

Total Scores
MCC	0.355
Average MCC ± 95% Confidence Intervals	0.384 ± 0.091
Sensitivity	0.182
Positive Predictive Value	0.696
Nr of predictions	22

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00716	HDV_ribozyme links to Rfam database...	-0.01	0.00	0.00	0	2688	13	0	13	0	23
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
PDB_01092	glmS links to Rfam database...	0.38	0.21	0.69	11	10137	6	0	5	1	41
RFA_00632	HDV_ribozyme links to Rfam database...	0.27	0.25	0.29	7	4071	17	0	17	0	21
RFA_00636	HDV_ribozyme links to Rfam database...	0.71	0.64	0.78	18	3982	5	2	3	0	10
RFA_00769	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	1944	0	0	0	0	9
RFA_00770	Corona_pk3 links to Rfam database...	0.71	0.50	1.00	9	2007	0	0	0	0	9
RFA_00773	Corona_pk3 links to Rfam database...	0.00	0.00	0.00	0	1949	4	0	4	0	18
RFA_00808	RydC links to Rfam database...	0.68	0.56	0.82	9	2005	2	0	2	0	7
RFA_00809	RydC links to Rfam database...	0.41	0.38	0.46	6	2132	7	1	6	0	10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

2. Individual counts for Afold [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]