CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Afold		NanoFolder
MCC	0.524	>	0.172
Average MCC ± 95% Confidence Intervals	0.508 ± 0.047	>	0.186 ± 0.041
Sensitivity	0.514	>	0.199
Positive Predictive Value	0.535	>	0.152
Total TP	3373	>	1306
Total TN	3849782	>	3847481
Total FP	3320	<	7546
Total FP CONTRA	443	<	1144
Total FP INCONS	2494	<	6161
Total FP COMP	383	>	241
Total FN	3186	<	5253
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Afold and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and NanoFolder).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Afold and NanoFolder).
Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and NanoFolder).

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Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP	3373
Total TN	3849782
Total FP	3320
Total FP CONTRA	443
Total FP INCONS	2494
Total FP COMP	383
Total FN	3186

Total Scores
MCC	0.524
Average MCC ± 95% Confidence Intervals	0.508 ± 0.047
Sensitivity	0.514
Positive Predictive Value	0.535
Nr of predictions	68

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2. Individual counts for Afold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00017	RNaseP_nuc links to Rfam database...	0.26	0.28	0.24	18	50965	74	6	51	17	46
ASE_00083	RNaseP_bact_a links to Rfam database...	0.71	0.67	0.76	74	62383	32	1	23	8	36
ASE_00122	RNaseP_bact_a links to Rfam database...	0.28	0.27	0.29	24	43283	60	4	54	2	64
ASE_00185	RNaseP_bact_a links to Rfam database...	0.72	0.70	0.74	89	73416	38	6	25	7	39
ASE_00190	RNaseP_bact_b links to Rfam database...	0.49	0.46	0.52	41	45372	44	7	31	6	49
ASE_00196	RNaseP_arch links to Rfam database...	0.76	0.75	0.77	56	31553	21	2	15	4	19
ASE_00221	RNaseP_bact_a links to Rfam database...	0.49	0.45	0.54	53	64522	48	3	42	3	64
ASE_00227	RNaseP_bact_a links to Rfam database...	0.25	0.23	0.27	31	78888	84	6	78	0	102
ASE_00228	RNaseP_bact_a links to Rfam database...	0.52	0.53	0.50	46	46879	46	14	32	0	40
ASE_00229	RNaseP_bact_a links to Rfam database...	0.61	0.61	0.62	53	42400	33	8	25	0	34
ASE_00231	RNaseP_bact_a links to Rfam database...	0.65	0.65	0.65	62	47800	33	5	28	0	34
ASE_00234	RNaseP_bact_a links to Rfam database...	0.58	0.53	0.62	69	75355	47	3	39	5	60
ASE_00238	RNaseP_bact_a links to Rfam database...	0.59	0.59	0.60	67	64150	50	2	42	6	47
ASE_00254	RNaseP_bact_a links to Rfam database...	0.49	0.46	0.52	38	36783	39	4	31	4	44
ASE_00255	RNaseP_bact_a links to Rfam database...	0.64	0.62	0.66	80	74570	45	7	34	4	50
ASE_00257	RNaseP_bact_a links to Rfam database...	0.55	0.55	0.55	53	50944	47	4	39	4	44
ASE_00267	RNaseP_bact_a links to Rfam database...	0.32	0.31	0.34	27	45070	62	5	48	9	61
ASE_00270	RNaseP_bact_a links to Rfam database...	0.76	0.73	0.80	94	72272	29	4	20	5	34
ASE_00274	RNaseP_bact_a links to Rfam database...	0.45	0.44	0.46	45	55513	54	10	43	1	58
ASE_00277	RNaseP_bact_a links to Rfam database...	0.38	0.38	0.38	35	48112	61	9	49	3	56
ASE_00279	RNaseP_bact_a links to Rfam database...	0.68	0.66	0.71	67	53206	35	3	25	7	34
ASE_00285	RNaseP_bact_a links to Rfam database...	0.75	0.70	0.80	86	68899	28	3	18	7	36
ASE_00287	RNaseP_bact_a links to Rfam database...	0.59	0.55	0.63	57	54856	39	2	31	6	46
ASE_00294	RNaseP_bact_a links to Rfam database...	0.74	0.68	0.80	117	114335	32	2	27	3	54
ASE_00295	RNaseP_bact_a links to Rfam database...	0.63	0.60	0.66	79	73801	42	8	32	2	52
ASE_00298	RNaseP_bact_a links to Rfam database...	0.28	0.27	0.29	31	67420	79	9	68	2	82
ASE_00340	RNaseP_bact_a links to Rfam database...	0.76	0.73	0.78	62	45977	26	6	11	9	23
ASE_00343	RNaseP_bact_a links to Rfam database...	0.34	0.35	0.34	39	83321	88	9	67	12	74
ASE_00367	RNaseP_bact_a links to Rfam database...	0.28	0.29	0.27	25	42979	68	8	59	1	61
ASE_00370	RNaseP_bact_a links to Rfam database...	0.63	0.63	0.62	53	41820	33	7	25	1	31
ASE_00372	RNaseP_bact_a links to Rfam database...	0.63	0.62	0.65	62	51907	39	6	28	5	38
ASE_00375	RNaseP_bact_a links to Rfam database...	0.70	0.66	0.74	73	60280	31	1	24	6	37
ASE_00376	RNaseP_bact_a links to Rfam database...	0.48	0.46	0.50	48	56857	52	4	44	4	57
ASE_00386	RNaseP_bact_a links to Rfam database...	0.65	0.65	0.65	62	50307	41	3	31	7	34
ASE_00393	RNaseP_bact_a links to Rfam database...	0.37	0.35	0.39	33	47811	58	2	49	7	60
ASE_00413	RNaseP_bact_a links to Rfam database...	0.55	0.58	0.52	47	44461	44	13	30	1	34
ASE_00416	RNaseP_bact_a links to Rfam database...	0.65	0.61	0.68	78	77307	43	0	36	7	49
ASE_00417	RNaseP_arch links to Rfam database...	0.36	0.37	0.35	37	54508	73	10	60	3	63
ASE_00422	RNaseP_bact_a links to Rfam database...	0.44	0.44	0.45	41	46880	56	5	45	6	53
ASE_00428	RNaseP_bact_a links to Rfam database...	0.51	0.50	0.53	62	76520	58	5	49	4	63
ASE_00429	-	0.43	0.44	0.43	29	28136	40	8	30	2	37
ASE_00430	RNaseP_bact_a links to Rfam database...	0.64	0.63	0.66	61	46878	39	5	27	7	36
ASE_00434	RNaseP_bact_b links to Rfam database...	0.61	0.60	0.62	66	68159	48	7	33	8	44
ASE_00437	RNaseP_bact_a links to Rfam database...	0.42	0.39	0.46	53	79285	64	4	59	1	82
ASE_00451	RNaseP_bact_a links to Rfam database...	0.61	0.57	0.66	71	70768	40	2	35	3	54
CRW_00648	-	0.61	0.64	0.59	94	137915	75	17	49	9	54
CRW_00654	-	0.70	0.68	0.72	84	78094	38	4	28	6	40
CRW_00663	-	0.14	0.15	0.13	9	26039	61	6	52	3	52
CRW_00664	-	0.05	0.05	0.04	4	53536	92	20	68	4	74
CRW_00671	Intron_gpI links to Rfam database...	0.66	0.64	0.68	75	62725	41	8	27	6	42
CRW_00672	Intron_gpI links to Rfam database...	0.74	0.73	0.74	81	72281	36	10	18	8	30
CRW_00674	Intron_gpI links to Rfam database...	0.55	0.55	0.55	68	83312	61	8	48	5	56
CRW_00676	Intron_gpI links to Rfam database...	0.54	0.56	0.52	64	93406	75	17	41	17	51
CRW_00685	-	0.38	0.42	0.34	44	156952	121	20	64	37	62
CRW_00721	-	0.52	0.60	0.46	41	58563	65	19	30	16	27
PDB_00078	-	0.47	0.45	0.50	52	49665	53	6	47	0	63
PDB_00278	-	0.13	0.13	0.13	9	24907	60	6	54	0	63
PDB_00571	tRNA links to Rfam database...	-0.01	0.00	0.00	0	3302	20	5	14	1	25
PDB_00701	-	0.47	0.46	0.49	50	45348	54	5	48	1	59
PDB_00828	Purine links to Rfam database...	0.88	0.78	1.00	21	2464	0	0	0	0	6
PDB_00917	-	0.49	0.47	0.51	45	35157	49	4	39	6	50
PDB_01009	tRNA links to Rfam database...	0.52	0.57	0.48	12	2460	13	5	8	0	9
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	6	0	2	4	8
RFA_00773	Corona_pk3 links to Rfam database...	0.71	0.56	0.91	10	1942	5	1	0	4	8
RFA_00808	RydC links to Rfam database...	-0.01	0.00	0.00	0	2001	16	2	13	1	16
TMR_00352	tmRNA links to Rfam database...	0.42	0.45	0.39	34	95179	91	17	36	38	41
TMR_00594	tmRNA links to Rfam database...	0.20	0.20	0.20	21	79294	90	15	71	4	83
TMR_00706	tmRNA links to Rfam database...	0.50	0.50	0.50	51	66328	55	6	45	4	52

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP	1306
Total TN	3847481
Total FP	7546
Total FP CONTRA	1144
Total FP INCONS	6161
Total FP COMP	241
Total FN	5253

Total Scores
MCC	0.172
Average MCC ± 95% Confidence Intervals	0.186 ± 0.041
Sensitivity	0.199
Positive Predictive Value	0.152
Nr of predictions	68

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00017	RNaseP_nuc links to Rfam database...	0.02	0.03	0.02	2	50914	131	38	86	7	62
ASE_00083	RNaseP_bact_a links to Rfam database...	0.22	0.25	0.20	27	62347	108	12	95	1	83
ASE_00122	RNaseP_bact_a links to Rfam database...	0.27	0.30	0.24	26	43258	84	13	68	3	62
ASE_00185	RNaseP_bact_a links to Rfam database...	0.17	0.19	0.16	24	73382	134	14	116	4	104
ASE_00190	RNaseP_bact_b links to Rfam database...	0.24	0.28	0.21	25	45334	93	14	78	1	65
ASE_00196	RNaseP_arch links to Rfam database...	0.49	0.57	0.42	43	31524	62	16	43	3	32
ASE_00221	RNaseP_bact_a links to Rfam database...	0.20	0.21	0.18	25	64484	112	10	101	1	92
ASE_00227	RNaseP_bact_a links to Rfam database...	0.28	0.31	0.25	41	78840	122	20	102	0	92
ASE_00228	RNaseP_bact_a links to Rfam database...	0.05	0.06	0.04	5	46858	109	17	91	1	81
ASE_00229	RNaseP_bact_a links to Rfam database...	0.12	0.14	0.11	12	42380	97	12	82	3	75
ASE_00231	RNaseP_bact_a links to Rfam database...	0.37	0.42	0.33	40	47773	84	17	65	2	56
ASE_00234	RNaseP_bact_a links to Rfam database...	0.25	0.27	0.23	35	75315	117	10	106	1	94
ASE_00238	RNaseP_bact_a links to Rfam database...	0.26	0.30	0.23	34	64111	119	18	98	3	80
ASE_00254	RNaseP_bact_a links to Rfam database...	0.15	0.16	0.14	13	36761	88	3	79	6	69
ASE_00255	RNaseP_bact_a links to Rfam database...	0.11	0.12	0.10	16	74530	146	16	129	1	114
ASE_00257	RNaseP_bact_a links to Rfam database...	0.37	0.42	0.33	41	50917	85	15	67	3	56
ASE_00267	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	45036	115	9	105	1	88
ASE_00270	RNaseP_bact_a links to Rfam database...	0.19	0.21	0.17	27	72232	132	14	117	1	101
ASE_00274	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	55487	126	12	112	2	103
ASE_00277	RNaseP_bact_a links to Rfam database...	0.10	0.12	0.08	11	48071	123	23	100	0	80
ASE_00279	RNaseP_bact_a links to Rfam database...	0.14	0.16	0.13	16	53177	109	16	92	1	85
ASE_00285	RNaseP_bact_a links to Rfam database...	0.34	0.36	0.31	44	68866	98	14	82	2	78
ASE_00287	RNaseP_bact_a links to Rfam database...	0.15	0.17	0.14	17	54824	107	14	91	2	86
ASE_00294	RNaseP_bact_a links to Rfam database...	0.12	0.13	0.12	23	114287	172	11	160	1	148
ASE_00295	RNaseP_bact_a links to Rfam database...	0.14	0.16	0.13	21	73761	140	19	119	2	110
ASE_00298	RNaseP_bact_a links to Rfam database...	0.09	0.10	0.08	11	67389	129	8	120	1	102
ASE_00340	RNaseP_bact_a links to Rfam database...	0.06	0.07	0.05	6	45943	110	13	94	3	79
ASE_00343	RNaseP_bact_a links to Rfam database...	0.14	0.17	0.12	19	83275	145	31	111	3	94
ASE_00367	RNaseP_bact_a links to Rfam database...	0.08	0.09	0.07	8	42960	110	10	93	7	78
ASE_00370	RNaseP_bact_a links to Rfam database...	0.03	0.04	0.03	3	41796	109	18	88	3	81
ASE_00372	RNaseP_bact_a links to Rfam database...	0.17	0.20	0.15	20	51871	113	19	93	1	80
ASE_00375	RNaseP_bact_a links to Rfam database...	0.12	0.14	0.11	15	60246	120	10	107	3	95
ASE_00376	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	56822	136	9	122	5	105
ASE_00386	RNaseP_bact_a links to Rfam database...	0.14	0.16	0.13	15	50284	106	9	95	2	81
ASE_00393	RNaseP_bact_a links to Rfam database...	0.31	0.35	0.27	33	47773	90	18	71	1	60
ASE_00413	RNaseP_bact_a links to Rfam database...	0.08	0.10	0.07	8	44438	108	19	86	3	73
ASE_00416	RNaseP_bact_a links to Rfam database...	0.39	0.43	0.35	54	77267	103	18	82	3	73
ASE_00417	RNaseP_arch links to Rfam database...	0.32	0.36	0.28	36	54486	98	18	75	5	64
ASE_00422	RNaseP_bact_a links to Rfam database...	0.28	0.31	0.25	29	46856	87	9	77	1	65
ASE_00428	RNaseP_bact_a links to Rfam database...	0.24	0.26	0.22	33	76483	121	13	107	1	92
ASE_00429	-	0.08	0.09	0.07	6	28114	84	14	69	1	60
ASE_00430	RNaseP_bact_a links to Rfam database...	0.16	0.18	0.14	17	46852	102	10	92	0	80
ASE_00434	RNaseP_bact_b links to Rfam database...	0.29	0.34	0.25	37	68116	122	20	92	10	73
ASE_00437	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	79238	164	12	151	1	135
ASE_00451	RNaseP_bact_a links to Rfam database...	0.20	0.22	0.19	27	70731	118	8	110	0	98
CRW_00648	-	0.05	0.06	0.04	9	137864	213	24	178	11	139
CRW_00654	-	0.41	0.47	0.36	58	78049	105	18	85	2	66
CRW_00663	-	0.08	0.10	0.07	6	26014	90	17	69	4	55
CRW_00664	-	0.14	0.19	0.11	15	53486	134	42	85	7	63
CRW_00671	Intron_gpI links to Rfam database...	0.18	0.21	0.16	24	62682	130	23	106	1	93
CRW_00672	Intron_gpI links to Rfam database...	0.36	0.43	0.31	48	72233	114	35	74	5	63
CRW_00674	Intron_gpI links to Rfam database...	0.16	0.19	0.14	23	83274	142	19	120	3	101
CRW_00676	Intron_gpI links to Rfam database...	0.11	0.14	0.09	16	93347	169	29	136	4	99
CRW_00685	-	0.11	0.15	0.08	16	156867	212	64	133	15	90
CRW_00721	-	0.22	0.31	0.15	21	58515	133	46	71	16	47
PDB_00078	-	0.00	0.00	0.00	0	49644	126	10	116	0	115
PDB_00278	-	0.04	0.06	0.04	4	24875	98	13	84	1	68
PDB_00571	tRNA links to Rfam database...	-0.01	0.00	0.00	0	3286	36	6	29	1	25
PDB_00701	-	0.04	0.05	0.04	5	45319	127	14	113	0	104
PDB_00828	Purine links to Rfam database...	0.30	0.33	0.28	9	2453	23	0	23	0	18
PDB_00917	-	0.31	0.34	0.29	32	35136	81	10	67	4	63
PDB_01009	tRNA links to Rfam database...	0.27	0.33	0.23	7	2455	25	3	20	2	14
RFA_00770	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1996	24	0	20	4	18
RFA_00773	Corona_pk3 links to Rfam database...	0.93	1.00	0.86	18	1932	9	3	0	6	0
RFA_00808	RydC links to Rfam database...	0.83	1.00	0.70	16	1993	7	7	0	0	0
TMR_00352	tmRNA links to Rfam database...	0.07	0.09	0.05	7	95133	171	39	87	45	68
TMR_00594	tmRNA links to Rfam database...	0.08	0.10	0.06	10	79238	156	30	123	3	94
TMR_00706	tmRNA links to Rfam database...	0.14	0.17	0.11	17	66281	133	29	103	1	86

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

2. Individual counts for Afold [ download as .csv ]

Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

2. Individual counts for NanoFolder [ download as .csv ]